CAS 64-73-3

Demeclocycline hydrochloride

Description:

Demeclocycline hydrochloride is a broad-spectrum antibiotic belonging to the tetracycline class, primarily used to treat various bacterial infections. It is characterized by its ability to inhibit protein synthesis in bacteria by binding to the 30S ribosomal subunit, thereby preventing the growth and reproduction of the microorganisms. This compound is typically administered orally and is known for its effectiveness against a range of gram-positive and gram-negative bacteria. Demeclocycline hydrochloride is also utilized in the treatment of conditions such as acne and certain types of infections caused by resistant bacteria. In addition to its antibacterial properties, it has been used in the management of conditions like inappropriate antidiuretic hormone secretion (SIADH) due to its ability to induce nephrogenic diabetes insipidus. The substance is generally well-tolerated, but it can cause side effects such as gastrointestinal disturbances and photosensitivity. As with other tetracyclines, it is contraindicated in children and pregnant women due to potential effects on bone and teeth development.

Formula: C₂₁H₂₁ClN₂O₈·ClH

InChI: InChI=1S/C21H21ClN2O8.ClH/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31;/h3-4,6-7,14-15,25-26,28-29,32H,5H2,1-2H3,(H2,23,31);1H/t6-,7-,14-,15-,21-;/m0./s1

InChI key: InChIKey=GVSJQNRGSCOSNJ-KBHRXELFSA-N

SMILES: O[C@]12[C@]([C@H](N(C)C)C(O)=C(C(N)=O)C1=O)(C[C@]3(C(=C2O)C(=O)C=4C([C@H]3O)=C(Cl)C=CC4O)[H])[H].Cl

Synonyms:

• 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, hydrochloride (1:1), (4S,4aS,5aS,6S,12aS)-
• 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, monohydrochloride
• 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, monohydrochloride, (4S,4aS,5aS,6S,12aS)-
• 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, monohydrochloride, [4S-(4α,4aα,5aα,6β,12aα)]-
• 6,10,12,12A-Pentahydroxy-1,11-Dioxo-Ydro-Monohydrochloride
• 6-Demethyl-7-chlorotetracycline hydrochloride
• 7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride
• 7-Chloro-4-Dimethylamino-3,6,10,12,12A-Pentahydroxy-1,11-Dioxo-1,4,4A,5,5A,6,11,12A-Octahydro-Naphthacene-2-Carboxamide Hydrochloride
• 7-Chloro-6-Demethyltetracycline Hydrochloride
• Clortetrin
• Declomycin
• Declomycin hydrochloride
• Declomycinhydrochloride
• Demeclocycline
• Demethylchlorotetracycline hydrochloride
• Demethylchlorotetracyclinehydrochloride
• Demethylchlortetracyclinehydrochloride
• Demetraciclina
• Detravis
• Ledermycin hydrochloride

Demeclocycline hydrochloride

CAS: 64-73-3

Demeclocycline hydrochloride is used as an antibiotic related to tetracycline and produced by streptomyces aureofaciens, and used to maintain effective blood levels for longer periods of time, used as a fluorescent bone-labeling agent in bone histomorphometry. This Thermo Scientific Chemicals brand

Formula: C₂₁H₂₁ClN₂O₈•HCl

Molecular weight: 501.32

Ref: 02-J63102

Demeclocycline Hydrochloride

CAS: 64-73-3

Color and Shape: Neat

Ref: 61-FOR0636.00

DEMECLOCYCLINE FOR SYSTEM SUITABILITY CRS

CAS: 64-73-3

DEMECLOCYCLINE FOR SYSTEM SUITABILITY CRS

Formula: C₂₁H₂₂Cl₂N₂O₈

Color and Shape: Yellow. Powder.

Molecular weight: 501.314

Ref: 41-Y0001707

DEMECLOCYCLINE HYDROCHLORIDE CRS

CAS: 64-73-3

DEMECLOCYCLINE HYDROCHLORIDE CRS

Formula: C₂₁H₂₂Cl₂N₂O₈

Color and Shape: Yellow. Powder.

Molecular weight: 501.314

Ref: 41-D0300000

Demeclocycline hydrochloride

CAS: 64-73-3

Demeclocycline hydrochloride

Formula: C₂₁H₂₁ClN₂O₈HCl

Purity: 90.2%

Color and Shape: Yellow

Molecular weight: 500.07532

Ref: 47-789

Demeclocycline Hydrochloride

CAS: 64-73-3

Tetracyclines and their derivatives; salts thereof

Formula: C₂₁H₂₁ClN₂O₈·HCI

Color and Shape: Yellow Crystalline Powder

Molecular weight: 501.31

Ref: 45-1170000

7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride

CAS: 64-73-3

Formula: C₂₁H₂₂Cl₂N₂O₈

Purity: 90%

Color and Shape: Solid

Molecular weight: 501.3140

Ref: IN-DA0039UL

Demeclocycline hydrochloride

CAS: 64-73-3

Demeclocycline HCl (Declomycin), a tetracycline with 7-Cl & 6-CH₃, has prolonged blood levels due to slower excretion.

Formula: C₂₁H₂₁ClN₂O₈·HCl

Purity: 96.21% - 99.14%

Color and Shape: Yellow Crystalline Powder Solid

Molecular weight: 501.32

Ref: TM-T1400

Demeclocycline HCl

CAS: 64-73-3

Formula: C₂₁H₂₁ClN₂O₈·HCl

Color and Shape: Yellow Solid

Molecular weight: 464.86 36.46

Ref: 4Z-D-721

(4S,4As,5As,6S,12As)-7-Chloro-4-(Dimethylamino)-3,6,10,12,12a-Pentahydroxy-1,11-Dioxo-1,4,4A,5,5A,6,11,12A-Octahydrotetracene-2-Carboxamide Hydrochloride

CAS: 64-73-3

(4S,4As,5As,6S,12As)-7-Chloro-4-(Dimethylamino)-3,6,10,12,12a-Pentahydroxy-1,11-Dioxo-1,4,4A,5,5A,6,11,12A-Octahydrotetracene-2-Carboxamide Hydrochloride

Purity: 90%

Molecular weight: 501.31g/mol

Ref: 54-OR1030500

Demeclocycline hydrochloride

CAS: 64-73-3

Formula: C₂₁H₂₁ClN₂O₈·HCl

Purity: 90.0 - 102.0 % (dried basis)

Color and Shape: Yellow powder

Molecular weight: 501.32

Ref: 7W-GA7186

Demeclocycline hydrochloride

CAS: 64-73-3

Demeclocycline hydrochloride

Purity: ≥95%

Molecular weight: 501.32g/mol

Ref: 54-BUP17020

PharmaVetResiMix 5 Tetracyclines-v10 10 µg/mL in Methanol

Controlled Product

CAS: 101342-45-4, 14206-58-7, 179471-95-5, 2058-46-0, 23313-80-6, 24390-14-5, 41411-66-9, 64-72-2, 64-73-3, 64-75-5

Color and Shape: Colourless

Ref: 04-A30000035ME

Demeclocycline Hydrochloride

Controlled Product

CAS: 64-73-3

Formula: C₂₁H₂₁ClN₂O₈·ClH

Color and Shape: Neat

Molecular weight: 501.31

Ref: 86-MM0636.00

Demeclocycline hydrochloride

Controlled Product

CAS: 64-73-3

Formula: C₂₁H₂₁ClN₂O₈·ClH

Color and Shape: Neat

Molecular weight: 501.31

Ref: 04-C12128000

Demeclocycline Hydrochloride

CAS: 64-73-3

Applications An antibiotic related to tetracycline and produced by streptomyces aureofaciens. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.This compound is a contaminant of emerging concern (CECs).
References Jilka, R., et al.: J. Clin. Invest., 104, 439 (1999), Hauge, E; Bone, 28, 556 (2001), Dobnig, H., et al.: J. Clin. Endocrinol. Metab., 90, 3970 (2005),

Formula: C₂₁H₂₁ClN₂O₈·ClH

Color and Shape: Light Yellow To Yellow

Molecular weight: 501.31

Ref: TR-D230725

Demeclocycline hydrochloride

CAS: 64-73-3

Demeclocycline hydrochloride is a tetracycline antibiotic that binds to the tetracycline receptor and inhibits bacterial protein synthesis. Demeclocycline hydrochloride has been shown to be effective against many types of bacteria, including those that are resistant to other antibiotics such as methicillin or vancomycin. Demeclocycline hydrochloride has been used in the treatment of skin cancer and also has anti-inflammatory properties. Demeclocycline hydrochloride is a hydrophobic molecule with a metal chelating ability that can be used for wastewater treatment.

Formula: C₂₁H₂₁ClN₂O₈·ClH

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 501.31 g/mol

Ref: 3D-FD20979

Demeclocycline hydrochloride

CAS: 64-73-3

Purity: 90%

Molecular weight: 501.3099976

Ref: 10-F869293