CAS 64-77-7

Tolbutamide

Description:

Tolbutamide is a sulfonylurea class medication primarily used in the management of type 2 diabetes mellitus. It functions by stimulating insulin secretion from the pancreatic beta cells, thereby lowering blood glucose levels. Chemically, tolbutamide is characterized by its molecular formula, which includes a sulfonyl group and an aromatic ring, contributing to its pharmacological activity. It is typically presented as a white to off-white crystalline powder, with a relatively low solubility in water, which can affect its absorption and bioavailability. The compound has a moderate melting point and is stable under normal conditions, although it should be stored away from light and moisture to maintain its efficacy. Tolbutamide is metabolized in the liver, and its effects can vary based on individual patient factors, including renal function. As with any medication, it may have side effects, including hypoglycemia and gastrointestinal disturbances, and should be used under medical supervision.

Formula: C₁₂H₁₈N₂O₃S

InChI: InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)

InChI key: InChIKey=JLRGJRBPOGGCBT-UHFFFAOYSA-N

SMILES: S(NC(NCCCC)=O)(=O)(=O)C1=CC=C(C)C=C1

Synonyms:

• 1-Butyl-3-(4-methylphenyl)sulfonylurea
• 1-Butyl-3-(p-methylphenylsulfonyl)urea
• 1-Butyl-3-(p-tolylsulfonyl)urea
• 1-Butyl-3-tosylurea
• 3-(p-Tolyl-4-sulfonyl)-1-butylurea
• 3-Butyl-1-(4-methylbenzenesulfonyl)urea
• Aglicid
• Arkozal
• Artosin
• Artozin
• Benzenesulfonamide, N-[(Butylamino)Carbonyl]-4- Methyl-
• Butamid
• Butamide
• D 860
• Diaben
• Diabetamid
• Diabetol
• Diabuton
• Diasulfon
• Dolipol
• Glyconon
• Hls 831
• Ipoglicone
• Mobenol
• N-(4-Methylbenzene) sulfonyl-N'-butylurea
• N-(4-Methylbenzenesulfonyl)-N'-butylurea
• N-(4-Methylphenylsulfonyl)-N'-butylurea
• N-(Sulfonyl-p-methylbenzene)-N'-n-butylurea
• N-(p-Methylbenzenesulfonyl)-N'-butylurea
• N-(p-Tolylsulfonyl)-N'-butylcarbamide
• N-Butyl-N'-(4-methylphenylsulfonyl)urea
• N-Butyl-N'-(P-Tolylsulfonyl)-Harnstoff
• N-Butyl-N'-(p-tolylsulfonyl)urea
• N-Butyl-N'-p-toluenesulfonylurea
• N-[(Butylamino)carbonyl]-4-methylbenzenesulfonamide
• N-n-Butyl-N'-tosylurea
• Nsc 23813
• Nsc 87833
• Orabet
• Oralin
• Orezan
• Orinase
• Orinaz
• Oterben
• Pramidex
• Rastinon
• Tolbusal
• Tolbutamid
• Tolbutamida
• Toluina
• Tolumid
• Tolumide
• Toluvan
• U 2043
• Urea, 1-butyl-3-(p-tolylsulfonyl)-

Tolbutamide, 98%

CAS: 64-77-7

Tolbutamide, have been used in a cDNA microarray assay to probe changes in gene expression in HepG2 cells upon their administration. It has been utilized to counteract insulin activity in a patch-clamp investigation of ATP sensitive K+ channels in mouse pancreatic -cells. The activity of various bio

Formula: C₁₂H₁₈N₂O₃S

Purity: 98%

Color and Shape: White to pale cream, Powder or crystalline powder

Molecular weight: 270.35

Ref: 02-B21698

Tolbutamide 1.0 mg/ml in Acetonitrile

CAS: 64-77-7

Color and Shape: Single Solution

Ref: 61-AMP1089.00-11

TOLBUTAMIDE CRS

CAS: 64-77-7

TOLBUTAMIDE CRS

Formula: C₁₂H₁₈N₂O₃S

Color and Shape: Crystalline Powder. White. Powder.

Molecular weight: 270.3479

Ref: 41-T1700000

Tolbutamide

CAS: 64-77-7

Sulfonamides used as drugs

Formula: C₁₂H₁₈N₂O₃S

Color and Shape: White Crystalline Powder

Molecular weight: 270.10381

Ref: 45-1670003

Tolbutamide

CAS: 64-77-7

Tolbutamide (HLS 831) is a sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE.

Formula: C₁₂H₁₈N₂O₃S

Purity: 99.80% - 99.93%

Color and Shape: White Crystalline Powder

Molecular weight: 270.35

Ref: TM-T1054

Benzenesulfonamide, N-​[(butylamino)​carbonyl]​-​4-​methyl-

CAS: 64-77-7

Formula: C₁₂H₁₈N₂O₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 270.3479

Ref: IN-DA00E9I8

Tolbutamide

CAS: 64-77-7

Tolbutamide

Purity: ≥98%

Molecular weight: 270.35g/mol

Ref: 54-BUP18358

Tolbutamide

CAS: 64-77-7

Tolbutamide

Purity: 99%

Molecular weight: 270.35g/mol

Ref: 54-OR1028654

Tolbutamide

CAS: 64-77-7

Formula: C₁₂H₁₈N₂O₃S

Molecular weight: 270.35

Ref: 7W-GP0797

Tolbutamide

CAS: 64-77-7

Formula: C₁₂H₁₈N₂O₃S

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 270.35

Ref: 3B-T3690

Tolbutamide

Controlled Product

CAS: 64-77-7

Formula: C₁₂H₁₈N₂O₃S

Color and Shape: Neat

Molecular weight: 270.35

Ref: 86-MM1089.00

Tolbutamide

CAS: 64-77-7

Formula: C₁₂H₁₈N₂O₃S

Color and Shape: Neat

Molecular weight: 270.35

Ref: 04-C17589900

Tolbutamide

CAS: 64-77-7

Formula: C₁₂H₁₈N₂O₃S

Molecular weight: 270.35

Ref: 4Z-T-048

Tolbutamide RS

CAS: 64-77-7

Color and Shape: White

Ref: 2K-1099000021

Tolbutamide

Controlled Product

CAS: 64-77-7

Formula: C₁₂H₁₈N₂O₃S

Color and Shape: Off-White

Molecular weight: 270.35

Ref: TR-T535150

Tolbutamide

CAS: 64-77-7

Tolbutamide is a drug that is used to treat diabetes mellitus type 2. It is an inhibitor of the enzyme glucokinase and thus blocks the phosphorylation of glucose, which prevents its utilization by cells. This results in a decrease of blood glucose levels, which can be useful in the treatment of diabetes mellitus type 2. Tolbutamide has shown potent apoptosis-inducing effects on human breast cancer cells and endothelial cells. These effects are thought to be due to inhibition of protein kinase C (PKC) activity by tolbutamide. Additionally, this drug inhibits insulin secretion from pancreatic beta cells and induces cytochrome P450 enzymes, which may lead to increased metabolism of other drugs.

Formula: C₁₂H₁₈N₂O₃S

Purity: Min. 95%

Molecular weight: 270.35 g/mol

Ref: 3D-FT28304

Tolbutamide

CAS: 64-77-7

Formula: C₁₂H₁₈N₂O₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 270.35

Ref: 10-F047218

Tolbutamide

CAS: 64-77-7

Color and Shape: Neat

Ref: 61-FOR1089.00