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CAS 64-77-7

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Tolbutamide

Description:
Tolbutamide is a sulfonylurea class medication primarily used in the management of type 2 diabetes mellitus. It functions by stimulating insulin secretion from the pancreatic beta cells, thereby lowering blood glucose levels. Chemically, tolbutamide is characterized by its molecular formula, which includes a sulfonyl group and an aromatic ring, contributing to its pharmacological activity. It is typically presented as a white to off-white crystalline powder, with a relatively low solubility in water, which can affect its absorption and bioavailability. The compound has a moderate melting point and is stable under normal conditions, although it should be stored away from light and moisture to maintain its efficacy. Tolbutamide is metabolized in the liver, and its effects can vary based on individual patient factors, including renal function. As with any medication, it may have side effects, including hypoglycemia and gastrointestinal disturbances, and should be used under medical supervision.
Formula:C12H18N2O3S
InChI:InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)
InChI key:InChIKey=JLRGJRBPOGGCBT-UHFFFAOYSA-N
SMILES:S(NC(NCCCC)=O)(=O)(=O)C1=CC=C(C)C=C1
Synonyms:
  • 1-Butyl-3-(4-methylphenyl)sulfonylurea
  • 1-Butyl-3-(p-methylphenylsulfonyl)urea
  • 1-Butyl-3-(p-tolylsulfonyl)urea
  • 1-Butyl-3-tosylurea
  • 3-(p-Tolyl-4-sulfonyl)-1-butylurea
  • 3-Butyl-1-(4-methylbenzenesulfonyl)urea
  • Aglicid
  • Arkozal
  • Artosin
  • Artozin
  • See more synonyms
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