CAS 641-77-0

4-pregnene-11-B-17-A-diol-3-20-dione

Description:

4-Pregnene-11β,17α-diol-3,20-dione, commonly known as 17α-hydroxyprogesterone, is a steroid hormone that plays a crucial role in the regulation of various physiological processes. It is a derivative of progesterone and is characterized by its specific structural features, including a pregnene backbone with hydroxyl groups at the 11 and 17 positions and a ketone at the 3 and 20 positions. This compound is primarily involved in the biosynthesis of other steroid hormones and is significant in reproductive health, particularly in pregnancy. It is synthesized in the adrenal glands and gonads and is known for its role in maintaining pregnancy and regulating menstrual cycles. In clinical settings, 17α-hydroxyprogesterone is used therapeutically to prevent preterm birth in at-risk pregnancies. The substance is typically administered in various forms, including injections or oral formulations. Its pharmacological effects are mediated through interactions with specific steroid hormone receptors, influencing gene expression and cellular activity. As with many steroid hormones, its levels in the body are tightly regulated and can be affected by various physiological and pathological conditions.

Formula: C₂₁H₃₀O₄

InChI: InChI=1/C21H30O4/c1-12(22)21(25)9-7-16-15-5-4-13-10-14(23)6-8-19(13,2)18(15)17(24)11-20(16,21)3/h10,15-18,24-25H,4-9,11H2,1-3H3

InChI key: InChIKey=LCZBQMKVFQNSJR-UJPCIWJBSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(CC3)=CC(=O)CC4)([C@@H](O)C1)[H])[H])(CC[C@@]2(C(C)=O)O)[H]

Synonyms:

• (11Alpha)-11,17-Dihydroxypregn-4-Ene-3,20-Dione
• (11Beta)-11,17-Dihydroxypregn-4-Ene-3,20-Dione
• (11β)-11,17-Dihydroxypregn-4-ene-3,20-dione
• 11,17-Dihydroxypregn-4-Ene-3,20-Dione
• 11-Beta,17-Alpha-Dihydroxypregn-4-Ene-3,20-Dione
• 11β,17α-Dihydroxypregn-4-ene-3,20-dione
• 11β,17α-Dihydroxyprogesterone
• 21-Dehydrohydrocortisone
• 21-Deoxycortisol
• 21-Deoxyhydrocortisone
• 21-Desoxycortisol
• Pregn-4-ene-11β,17α-diol-3,20-dione
• Pregn-4-ene-3,20-dione, 11,17-dihydroxy-, (11β)-
• Pregn-4-ene-3,20-dione, 11β,17-dihydroxy-
• Progesterone, 11β,17-dihydroxy-
• 21 DEOXYCORTISOL 21-DESOXYCORTISOL
• 21-Deoxycortisol solution
• 4-Pregnene-11β,17α-diol-3,20-dione
• 4-Pregnen-11,17a-diol-3,20-dione-d8
• Hydrocortisone EP Impurity L Q: What is the CAS Number of
• Hydrocortisone EP Impurity L (Oxenol)
• HYDROCORTISONE IMPURITY L (OXENOL)
• (8S,9S,10R,13S,14S,17R)-17-acetyl-11,17-dihydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
• Desoxycortisol (solution)
• 11β,17α-Dihydroxy-4-pregnene-3,20-dione, 11β,17α-Dihydroxyprogesterone, 21-Desoxycortisol, 4-Pregnene-11β,17α-diol-3,20-dione
• Hydrocortisone EP Impurity L Q: What are the applications of
• 4-pregnene-11-B-17-A-diol-3-20-dione
• Hydrocortisone impurity L (EP)
• Hydrocortisone EP Impurity L
• 11β,17-Dihydroxypogesterone
• Hydrocortisone EP IMP L
• C05497
• Desoxycortisol
• 11BETA,17ALPHA-DIHYDROXY-PROGESTERONE
• 11β,17α-Dihydroxy-4-pregnene-3,20-dione
• 11BETA,17ALPHA-DIHYDROXY-4-PREGNENE-3,20-DIONE
• Hydrocortisone EP Impurity LQ: What is
• Hydrocortisone EP Impurity L (Hydrocortisone Acetate EP Impurity B)
• Hydrocortisone Acetate EP Impurity B (Hydrocortisone EP Impurity L)
• (8S,9S,10R,11S,13S,14S,17R)-17-Acetyl-11,17-dihydroxy-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
• Hydrocortisone Impurity L
• 4-PREGNEN-11BETA,17ALPHA-DIOL-3,20-DIONE
• Hydrocortisone EP Impurity L Q: What is the storage condition of
• 4-PREGNENE-11BETA,17ALPHA-DIOL-3,20-DIONE
• Hydrocortisone Impurity 12（Hydrocortisone EP Impurity L）
• 11β,17-Dihydroxypregn-4-ene-3,20-dione
• Hydrocortisone Acetate EP Impurity B

21-Deoxycortisol (11β,17-Dihydroxypregn-4-ene-3,20-dione)

CAS: 641-77-0

Ketone-alcohols and ketone-aldehydes, nesoi

Formula: C₂₁H₃₀O₄

Color and Shape: White Powder

Molecular weight: 346.21441

Ref: 45-1A10610

(8S,9S,10R,11S,13S,14S,17R)-17-Acetyl-11,17-dihydroxy-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one

CAS: 641-77-0

Formula: C₂₁H₃₀O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 346.4605

Ref: IN-DA00EBWG

Hydrocortisone EP Impurity L (Hydrocortisone Acetate EP Impurity B, Oxenol)

CAS: 641-77-0

Formula: C₂₁H₃₀O₄

Molecular weight: 346.47

Ref: 4Z-H-103022

21-Deoxycortisol

CAS: 641-77-0

21-Deoxycortisol

Purity: 98%

Ref: 54-OR1039799

11β,17-Dihydroxypregn-4-ene-3,20-dione (Oxenol)

CAS: 641-77-0

Color and Shape: Neat

Ref: 86-MM0185.28

21-Deoxy Cortisol

Controlled Product

CAS: 641-77-0

Impurity Hydrocortisone EP Impurity L
Applications 21-Deoxy Cortisol (Hydrocortisone EP Impurity L) is a metabolite of Fluticasone propionate (F599500).
References Li, S., et al.: Science, 303, 540 (2004), Fliri, A., et al.: J. Med. Chem., 48, 6918 (2005), Ekins, S., et al.: J. Pharmacol. Toxicol. Methods, 53, 38 (2006),

Formula: C₂₁H₃₀O₄

Color and Shape: Neat

Molecular weight: 346.46

Ref: TR-D232605

21-Deoxycortisol

Controlled Product

CAS: 641-77-0

21-Deoxycortisol is a synthetic steroid that is used as a diagnostic agent in vitro to differentiate between deficiency type I (21-hydroxylase) and deficiency type II (11β-hydroxylase) of the adrenal gland. 21-Deoxycortisol has structural similarity to cortisol, but it does not bind to receptors in the body. The absence of this binding makes it useful for diagnosis. The measurement of serum cortisol levels can be used to diagnose these deficiencies as well, but this test is less specific than the 21-deoxycortisol assay. In addition, there are significant interactions with other drugs that may affect the accuracy of these measurements. This drug is also used as a model system for studying physiological processes and interactions with drugs.

Formula: C₂₁H₃₀O₄

Purity: Min. 95%

Color and Shape: Off-White Powder

Molecular weight: 346.46 g/mol

Ref: 3D-FD21046

Hydrocortisone EP Impurity L

CAS: 641-77-0

Formula: C₂₁H₃₀O₄

Molecular weight: 346.5

Ref: ST-EA-CP-H9012