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CAS 641571-10-0

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Nilotinib

Description:
Nilotinib is a targeted therapy medication primarily used in the treatment of chronic myeloid leukemia (CML) that is resistant or intolerant to prior therapies. It is classified as a tyrosine kinase inhibitor (TKI) and specifically inhibits the BCR-ABL fusion protein, which is responsible for the uncontrolled proliferation of leukemic cells. Nilotinib is characterized by its high selectivity for BCR-ABL, which minimizes off-target effects and enhances its therapeutic efficacy. The compound is typically administered orally and is known for its favorable pharmacokinetic profile, including good absorption and a long half-life, allowing for once or twice daily dosing. Common side effects may include hematologic toxicities, gastrointestinal disturbances, and metabolic changes. Nilotinib's chemical structure includes a pyrimidine ring and a phenyl group, contributing to its potency and specificity. As a second-generation TKI, it represents an advancement over earlier treatments, providing an important option for patients with specific genetic mutations associated with CML.
Formula:C28H22F3N7O
InChI:InChI=1/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)
InChI key:InChIKey=HHZIURLSWUIHRB-UHFFFAOYSA-N
SMILES:C(F)(F)(F)C=1C=C(C=C(NC(=O)C2=CC(NC=3N=C(C=CN3)C=4C=CC=NC4)=C(C)C=C2)C1)N5C=NC(C)=C5
Synonyms:
  • 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-N-[5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl]benzamide
  • 4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzamide
  • 4-Methyl-N-[3-(4-methylimidazol-1-yl)-5-trifluoromethylphenyl]-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]benzamide
  • 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzamide
  • 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4 -pyridin-3-ylpyrimidin-2-yl)amino]benzamide Nilotinib(TINIBS )
  • Amn 107
  • Benzamide, 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-
  • Nilotinib
  • Nilotinib & its intermediates (Developing)
  • Nilotinib for research
  • See more synonyms
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