CAS 64350-24-9

N-(2-methylpropanoyl)guanosine

Description:

N-(2-methylpropanoyl)guanosine is a modified nucleoside that features a guanosine base linked to a 2-methylpropanoyl group. This compound is characterized by its structural components, which include a purine base (guanine), a ribose sugar, and an acyl group derived from 2-methylpropanoic acid. The presence of the acyl group can influence the compound's solubility, stability, and biological activity, potentially affecting its interactions with enzymes and other biomolecules. N-(2-methylpropanoyl)guanosine may exhibit unique properties compared to unmodified guanosine, such as altered binding affinities or enhanced stability in biological systems. This modification can be of interest in biochemical research, particularly in studies involving nucleic acid interactions, signaling pathways, or drug design. As with many nucleoside derivatives, its characteristics may include specific melting points, solubility in various solvents, and reactivity under certain conditions, which are essential for understanding its potential applications in medicinal chemistry and molecular biology.

Formula: C₁₄H₁₉N₅O₆

InChI: InChI=1/C14H19N5O6/c1-5(2)11(23)17-14-16-10-7(12(24)18-14)15-4-19(10)13-9(22)8(21)6(3-20)25-13/h4-6,8-9,13,20-22H,3H2,1-2H3,(H2,16,17,18,23,24)/t6-,8-,9-,13-/m1/s1

SMILES: CC(C)C(=Nc1nc2c(c(n1)O)ncn2[C@H]1[C@@H]([C@@H]([C@@H](CO)O1)O)O)O

Synonyms:

• Guanosine, N-(2-methyl-1-oxopropyl)-
• N-(2-Methyl-1-oxopropyl)guanosine
• N2-Isobutyrylguanosine
• N-Isobutyrylguanosine
• N2-Isobutyryl-guanosine
• N2-(2-Methylpropanoyl)-Guanosine
• N2-Isobutyryl-D-guanosine
• ibu-rG
• N2-(2-METHYLPROPANOYL)-GUANOSINE USP/EP/BP
• N-{9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-2-methylpropanamide
• N-[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-oxo-3H-purin-2-yl]-2-methylpropanamide
• N2-ISOBUTYRYLGUANOSINE MONOHYDRATE
• N2-Isobutyrylguanosine Hydrate
• N2-iBu-Gr
• N-Isobutyryl guanosine
• N
• N2-iBu-rG
• 2
• -Isobutyrylguanosine

N2-(2-Methylpropanoyl)-guanosine

CAS: 64350-24-9

Formula: C₁₄H₁₉N₅O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 353.3306

Ref: IN-DA003SNU

N2-Isobutyrylguanosine

CAS: 64350-24-9

Ref: 7W-GN0224

N2-Iso-Butyryl Guanosine

CAS: 64350-24-9

N2-Iso-Butyryl Guanosine is a nucleoside derivative suitable for biochemical experiments and drug synthesis research.

Formula: C₁₄H₁₉N₅O₆

Purity: 99.26%

Color and Shape: White Solid

Molecular weight: 353.33

Ref: TM-TNU1135

N2-Isobutyrylguanosine

CAS: 64350-24-9

Formula: C₁₄H₁₉N₅O₆

Color and Shape: White to Almost white powder to crystal

Molecular weight: 353.34

Ref: 3B-I0699

N2-(2-Methylpropanoyl)guanosine

CAS: 64350-24-9

N2-(2-Methylpropanoyl)guanosine

Formula: C₁₄H₁₉N₅O₆

Purity: 97%

Color and Shape: Solid-Powder

Molecular weight: 353.33056

Ref: 54-OR930002

N-Isobutyrylguanosine

CAS: 64350-24-9

N-(9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

Formula: C₁₄H₁₉N₅O₆

Purity: 95%

Molecular weight: 353.33

Ref: IN-DG142758

N2-Isobutyrylguanosine

CAS: 64350-24-9

N2-Isobutyrylguanosine is a synthetic nucleoside analog. It is activated by the enzyme thymidine kinase and inhibits the synthesis of RNA and DNA, which leads to cell death. N2-Isobutyrylguanosine has been shown to be an effective inhibitor of epidermal growth factor receptor (EGFR) in mammalian cells. This drug has also been shown to inhibit insulin-like growth factor I and phosphorothioate monomers. N2-Isobutyrylguanosine inhibits the synthesis of fatty acids, leading to a decrease in lipid content in cells.

Formula: C₁₄H₁₉N₅O₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 353.33 g/mol

Ref: 3D-NI03488

N-Isobutyrylguanosine

CAS: 64350-24-9

Formula: C₁₄H₁₉N₅O₆

Purity: 97%

Color and Shape: Solid, White to almost white powder

Molecular weight: 353.335

Ref: 10-F239503

N-Isobutyrylguanosine

Controlled Product

CAS: 64350-24-9

Applications N-Isobutyrylguanosine is used in the syntehsis of 2'-O-(o-nitrobenzyl)-3'-thioguanosine phosphoramidite which is then used to form oligonucleotides, substrates for probing the mechanism of RNA catalysis.
References Li, N., et. al.: J. Org. Chem., 79, 3647 (2014)

Formula: C₁₄H₁₉N₅O₆

Color and Shape: Neat

Molecular weight: 353.33

Ref: TR-I780120

N2-Isobutyrylguanosine

CAS: 64350-24-9

Formula: C₁₄H₁₉N₅O₆

Molecular weight: 353.34

Ref: ST-EA-CP-A88079