CAS 65-28-1

Phentolamine methanesulfonate

Description:

Phentolamine methanesulfonate is a non-selective alpha-adrenergic antagonist primarily used in clinical settings to manage conditions such as hypertension and to counteract the effects of certain types of anesthesia. It is a salt form of phentolamine, which enhances its solubility and bioavailability. The compound appears as a white to off-white crystalline powder and is soluble in water, making it suitable for intravenous administration. Its mechanism of action involves blocking alpha-adrenergic receptors, leading to vasodilation and a decrease in blood pressure. Phentolamine methanesulfonate is also utilized in the treatment of pheochromocytoma, a tumor of the adrenal gland that secretes excess catecholamines. Side effects may include tachycardia, dizziness, and gastrointestinal disturbances. Due to its pharmacological properties, it is essential to monitor patients closely when administering this medication, particularly in those with cardiovascular issues. Overall, phentolamine methanesulfonate is a valuable therapeutic agent in specific medical scenarios, highlighting the importance of adrenergic receptor modulation in pharmacotherapy.

Formula: C₁₇H₁₉N₃O·CH₄O₃S

InChI: InChI=1S/C17H19N3O.CH4O3S/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;1-5(2,3)4/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H3,(H,2,3,4)

InChI key: InChIKey=OGIYDFVHFQEFKQ-UHFFFAOYSA-N

SMILES: S(C)(=O)(=O)O.N(CC=1NCCN1)(C2=CC(O)=CC=C2)C3=CC=C(C)C=C3

Synonyms:

• 3-[(4,5-dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]phenol methanesulfonate (1:1)
• M-(N-(2-Imidazolin-2-Ylmethyl)-P-Toluidino)-
• Phenol, 3-[[(4,5-dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)amino]-, methanesulfonate (1:1)
• Phenol, 3-[[(4,5-dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)amino]-, monomethanesulfonate (salt)
• Phenol, m-[N-(2-imidazolin-2-ylmethyl)-p-toluidino]-, monomethanesulfonate (salt)
• Phenomonomethanesulfonate
• Phentolamine Mesilate
• Phentolamine Methanesulfonate
• Phentolamine methanesulfonate salt
• Phentolamine methanesulphonate
• Phentolaminemethanesulphonate
• Regitin methanesulphonate
• Regitine mesylate
• Regitine methanesulfonate
• Rogitine
• Vasomax
• m-[N-(2-Imidazolin-2-ylmethyl)-p-toluidino]phenol methanesulfonate

Phentolamine Mesylate

CAS: 65-28-1

Formula: C₁₇H₁₉N₃O·CH₄O₃S

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 377.46

Ref: 3B-P1985

PHENTOLAMINE MESILATE CRS

CAS: 65-28-1

PHENTOLAMINE MESILATE CRS

Formula: C₁₈H₂₃N₃O₄S

Color and Shape: Crystalline Powder. White. Powder.

Molecular weight: 377.4579

Ref: 41-Y0001127

PHENTOLAMINE FOR SYSTEM SUITABILITY CRS

CAS: 65-28-1

PHENTOLAMINE FOR SYSTEM SUITABILITY CRS

Formula: C₁₈H₂₃N₃O₄S

Molecular weight: 377.4579

Ref: 41-Y0001251

Phentolamine mesilate

CAS: 65-28-1

Phentolamine mesilate

Formula: C₁₈H₂₃N₃O₄S

Purity: 99.0%

Color and Shape: Off-White

Molecular weight: 377.14093

Ref: 47-520

Phentolamine impurity standard

CAS: 65-28-1

Phentolamine impurity standard

Color and Shape: Off-White

Ref: 47-1099

Phentolamine Mesylate

CAS: 65-28-1

Compounds containing an unfused imidazole ring, whether or not hydrogenated, in the structure, nesoi

Formula: C₁₇H₁₉N₃O·CH₄O₃S

Color and Shape: White Off-White Crystalline Powder

Molecular weight: 377.14093

Ref: 45-1530004

Phentolamine mesylate

CAS: 65-28-1

Phentolamine mesylate: nonselective alpha-blocker for hypertension, pheochromocytoma, Raynaud's, frostbite, impotence, and vascular issues.

Formula: C₁₇H₁₉N₃O·CH₄O₃S

Purity: 99.87% - >99.99%

Color and Shape: By The Metabolic Processes Of Bacillus Subtilis And Licheniformis

Molecular weight: 377.46

Ref: TM-T1275

Phentolamine mesylate

CAS: 65-28-1

Formula: C₁₇H₁₉N₃O·CH₃SO₃H

Purity: ≥ 98.0%

Color and Shape: White to off-white crystalline powder

Molecular weight: 377.46

Ref: 7W-GP7407

Phentolamine mesylate

CAS: 65-28-1

Phentolamine mesylate

Purity: ≥98%

Molecular weight: 377.46g/mol

Ref: 54-BUP17117

Phentolamine Mesylate

CAS: 65-28-1

Phentolamine Mesylate

Purity: 98%

Molecular weight: 377.46g/mol

Ref: 54-OR1029394

Phentolamine Mesylate

CAS: 65-28-1

Formula: C₁₇H₁₉N₃O·CH₄O₃S

Color and Shape: White To Off-White Solid

Molecular weight: 281.36 96.11

Ref: 4Z-P-189001

Phentolamine Mesilate

CAS: 65-28-1

Formula: C₁₇H₁₉N₃O·CH₄O₃S

Color and Shape: Neat

Molecular weight: 377.46

Ref: 86-MM1310.00

Phentolamine Methanesulfonate Salt

Controlled Product

CAS: 65-28-1

Stability Aq. Solutions Cannot be Stored
Applications Phentolamine Methanesulfonate Salt is an adrenergic blocking agent. An antihypertensive. Used for the treatment of pheochromocytoma.
References Meier, R., et al.: Proc. Soc. Exp. Biol. Med., 71, 70 (1949); Spergel, G., et al.: J. Am. Med. Assoc., 211, 266 (1970); Gould, L. and Reddy, C.V.R.: Am. Heart J., 92, 397 (1976);

Formula: C₁₇H₁₉N₃O·CH₄O₃S

Color and Shape: Off-White

Molecular weight: 377.46

Ref: TR-P302560

Phentolamine methanesulfonate

CAS: 65-28-1

Phentolamine is a synthetic mesylate that is used as an antihypertensive agent, and for the treatment of Raynaud's syndrome and pheochromocytoma. Phentolamine is also used to prevent frostbite and to treat various types of shock. Phentolamine blocks alpha-2-adrenergic receptors, thereby decreasing sympathetic nerve impulses to the heart, blood vessels, kidneys, and other organs. This drug also acts as a histamine antagonist by blocking H1-receptors on vascular smooth muscle cells. Phentolamine has been shown to have no significant effects on 5-hydroxytryptamine (5HT) release in vitro or in vivo.

Formula: C₁₈H₂₃N₃O₄S

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 377.46 g/mol

Ref: 3D-FP26896

Phentolamine Mesilate

CAS: 65-28-1

Color and Shape: Neat

Ref: 61-FOR1310.00