CAS 65-28-1
:Phentolamine methanesulfonate
Description:
Phentolamine methanesulfonate is a non-selective alpha-adrenergic antagonist primarily used in clinical settings to manage conditions such as hypertension and to counteract the effects of certain types of anesthesia. It is a salt form of phentolamine, which enhances its solubility and bioavailability. The compound appears as a white to off-white crystalline powder and is soluble in water, making it suitable for intravenous administration. Its mechanism of action involves blocking alpha-adrenergic receptors, leading to vasodilation and a decrease in blood pressure. Phentolamine methanesulfonate is also utilized in the treatment of pheochromocytoma, a tumor of the adrenal gland that secretes excess catecholamines. Side effects may include tachycardia, dizziness, and gastrointestinal disturbances. Due to its pharmacological properties, it is essential to monitor patients closely when administering this medication, particularly in those with cardiovascular issues. Overall, phentolamine methanesulfonate is a valuable therapeutic agent in specific medical scenarios, highlighting the importance of adrenergic receptor modulation in pharmacotherapy.
Formula:C17H19N3O·CH4O3S
InChI:InChI=1S/C17H19N3O.CH4O3S/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;1-5(2,3)4/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H3,(H,2,3,4)
InChI key:InChIKey=OGIYDFVHFQEFKQ-UHFFFAOYSA-N
SMILES:S(C)(=O)(=O)O.N(CC=1NCCN1)(C2=CC(O)=CC=C2)C3=CC=C(C)C=C3
Synonyms:- 3-[(4,5-dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]phenol methanesulfonate (1:1)
- M-(N-(2-Imidazolin-2-Ylmethyl)-P-Toluidino)-
- Phenol, 3-[[(4,5-dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)amino]-, methanesulfonate (1:1)
- Phenol, 3-[[(4,5-dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)amino]-, monomethanesulfonate (salt)
- Phenol, m-[N-(2-imidazolin-2-ylmethyl)-p-toluidino]-, monomethanesulfonate (salt)
- Phenomonomethanesulfonate
- Phentolamine Mesilate
- Phentolamine Methanesulfonate
- Phentolamine methanesulfonate salt
- Phentolamine methanesulphonate
- Phentolaminemethanesulphonate
- Regitin methanesulphonate
- Regitine mesylate
- Regitine methanesulfonate
- Rogitine
- Vasomax
- m-[N-(2-Imidazolin-2-ylmethyl)-p-toluidino]phenol methanesulfonate
- See more synonyms
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Phentolamine Mesylate
CAS:Formula:C17H19N3O·CH4O3SPurity:>98.0%(HPLC)(T)Color and Shape:White to Light yellow to Light orange powder to crystalMolecular weight:377.46Phentolamine mesilate
CAS:Phentolamine mesilateFormula:C18H23N3O4SPurity:99.0%Color and Shape:Off-WhiteMolecular weight:377.14093PHENTOLAMINE MESILATE CRS
CAS:PHENTOLAMINE MESILATE CRSFormula:C18H23N3O4SColor and Shape:Added ModifiedMolecular weight:377.4579PHENTOLAMINE FOR SYSTEM SUITABILITY CRS
CAS:PHENTOLAMINE FOR SYSTEM SUITABILITY CRSFormula:C18H23N3O4SMolecular weight:377.4579Phentolamine Mesylate
CAS:Compounds containing an unfused imidazole ring, whether or not hydrogenated, in the structure, nesoiFormula:C17H19N3O·CH4O3SColor and Shape:White Off-White Crystalline PowderMolecular weight:377.14093Phentolamine Mesylate
CAS:Phentolamine MesylateFormula:C17H19N3OCH3SO3HPurity:98%Molecular weight:377.46Phentolamine mesylate
CAS:Phentolamine mesylateFormula:C17H19N3O·CH4O3SPurity:99.5%Molecular weight:377.46Phentolamine mesylate
CAS:Phentolamine mesylate: nonselective alpha-blocker for hypertension, pheochromocytoma, Raynaud's, frostbite, impotence, and vascular issues.Formula:C17H19N3O·CH4O3SPurity:99.87% - >99.99%Color and Shape:By The Metabolic Processes Of Bacillus Subtilis And LicheniformisMolecular weight:377.46Phentolamine mesylate
CAS:Formula:C17H19N3O·CH3SO3HPurity:≥ 98.0%Color and Shape:White to off-white crystalline powderMolecular weight:377.46Phentolamine Mesylate
CAS:Formula:C17H19N3O·CH4O3SColor and Shape:White To Off-White SolidMolecular weight:281.36 96.11Phentolamine methanesulfonate salt
CAS:3-(((4,5-Dihydro-1H-imidazol-2-yl)methyl)(p-tolyl)amino)phenol methanesulfonateFormula:C18H23N3O4SPurity:99%Molecular weight:377.46Phentolamine Methanesulfonate Salt
CAS:Controlled ProductStability Aq. Solutions Cannot be Stored
Applications Phentolamine Methanesulfonate Salt is an adrenergic blocking agent. An antihypertensive. Used for the treatment of pheochromocytoma.
References Meier, R., et al.: Proc. Soc. Exp. Biol. Med., 71, 70 (1949); Spergel, G., et al.: J. Am. Med. Assoc., 211, 266 (1970); Gould, L. and Reddy, C.V.R.: Am. Heart J., 92, 397 (1976);Formula:C17H19N3O·CH4O3SColor and Shape:NeatMolecular weight:377.46Phentolamine methanesulfonate
CAS:Phentolamine is a synthetic mesylate that is used as an antihypertensive agent, and for the treatment of Raynaud's syndrome and pheochromocytoma. Phentolamine is also used to prevent frostbite and to treat various types of shock. Phentolamine blocks alpha-2-adrenergic receptors, thereby decreasing sympathetic nerve impulses to the heart, blood vessels, kidneys, and other organs. This drug also acts as a histamine antagonist by blocking H1-receptors on vascular smooth muscle cells. Phentolamine has been shown to have no significant effects on 5-hydroxytryptamine (5HT) release in vitro or in vivo.
Formula:C18H23N3O4SPurity:Min. 95%Color and Shape:White PowderMolecular weight:377.46 g/mol
