CAS 65141-46-0

Nicorandil

Description:

Nicorandil is a pharmacological agent primarily used in the treatment of angina pectoris, functioning as both a nitrate and an ATP-sensitive potassium channel opener. Its chemical structure features a nicotinamide moiety linked to a nitro group, which contributes to its vasodilatory properties. Nicorandil acts by relaxing vascular smooth muscle, leading to increased blood flow and reduced myocardial oxygen demand. It is typically administered orally and has a relatively long half-life, allowing for sustained therapeutic effects. The substance is known for its ability to alleviate angina symptoms while also having a favorable side effect profile compared to traditional nitrates. However, it may cause side effects such as headache, dizziness, and gastrointestinal disturbances. Nicorandil is also associated with a risk of ulceration, particularly in long-term use. Its unique dual mechanism of action makes it a valuable option in managing chronic stable angina, especially in patients who do not respond adequately to other treatments. As with any medication, it is essential to use Nicorandil under medical supervision to monitor for potential adverse effects and interactions.

Formula: C₈H₉N₃O₄

InChI: InChI=1S/C8H9N3O4/c12-8(7-2-1-3-9-6-7)10-4-5-15-11(13)14/h1-3,6H,4-5H2,(H,10,12)

InChI key: InChIKey=LBHIOVVIQHSOQN-UHFFFAOYSA-N

SMILES: C(NCCON(=O)=O)(=O)C=1C=CC=NC1

Synonyms:

• 2-(Pyridine-3-carbonylamino)ethyl nitrate
• 2-Nicotinamidoethyl nitrate
• 2-[(3-Pyridinylcarbonyl)amino]ethyl nitrate
• 2-[(Pyridin-3-yl)formamido]ethyl nitrate
• 2-[(Pyridin-3-ylcarbonyl)amino]ethyl nitrate
• 2-[(Pyridin-3-ylcarbonyl)amino]ethylnitrat
• 265-514-1
• 3-Pyridinecarboxamide, N-[2-(nitrooxy)ethyl]-
• Coronel
• Dancor
• Ikorel
• N-(2-Hydroxyethyl)nicotinamide nitrate
• N-(2-Hydroxyethyl)nicotinamide nitrate ester
• N-(2-Nitrooxyethyl)nicotinamide
• N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide
• Perisalol
• Sg 75
• Sigmart

Nicorandil, 98+%

CAS: 65141-46-0

A vasodilator that activates ATP-sensitive potassium channels

Formula: C₈H₉N₃O₄

Purity: 98+%

Molecular weight: 211.17

Ref: 02-J60879

Nicorandil

CAS: 65141-46-0

Color and Shape: Neat

Ref: 61-FOR0924.00

NICORANDIL CRS

CAS: 65141-46-0

NICORANDIL CRS

Formula: C₈H₉N₃O₄

Color and Shape: White. Crystalline Powder.

Molecular weight: 211.1748

Ref: 41-Y0001761

Nicorandil

CAS: 65141-46-0

Nicorandil

Formula: C₈H₉N₃O₄

Purity: 99.2%

Color and Shape: White

Molecular weight: 211.05931

Ref: 47-1103

2-(pyridin-3-ylformamido)ethyl nitrate

CAS: 65141-46-0

Formula: C₈H₉N₃O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 211.1748

Ref: IN-DA003T3N

Nicorandil

CAS: 65141-46-0

Nicorandil

Formula: C₈H₉N₃O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 211.17475

Ref: 54-BIT0155

Nicorandil

CAS: 65141-46-0

Nicorandil (SG-75)(Ikorel) acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system.

Formula: C₈H₉N₃O₄

Purity: 98.14% - >99.99%

Color and Shape: White Solid

Molecular weight: 211.17

Ref: TM-T0075

Nicorandil

CAS: 65141-46-0

Formula: C₈H₉N₃O₄

Molecular weight: 211.18

Ref: 4Z-N-0537

Nicorandil

CAS: 65141-46-0

Nicorandil

Formula: C₈H₉N₃O₄

Purity: ≥98%

Color and Shape: Solid

Molecular weight: 211.17

Ref: 54-BUP14807

Nicorandil

CAS: 65141-46-0

Formula: C₈H₉N₃O₄

Purity: ≥ 98.0%

Color and Shape: White or off-white powder

Molecular weight: 211.17

Ref: 7W-GP5693

Nicorandil

CAS: 65141-46-0

Formula: C₈H₉N₃O₄

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 211.18

Ref: 3B-N0837

Nicorandil

Controlled Product

CAS: 65141-46-0

Formula: C₈H₉N₃O₄

Color and Shape: White

Molecular weight: 211.17

Ref: 86-MM0924.00

Nicorandil Impurity 10

CAS: 1132681-23-2, 65141-46-0

Formula: C₈H₁₀N₂O₂

Color and Shape: White To Off-White Solid

Molecular weight: 166.18

Ref: 4Z-N-0516

Nicorandil

CAS: 65141-46-0

Formula: C₈H₉N₃O₄

Molecular weight: 211.18

Ref: ST-EA-CP-N34000

Nicorandil

Controlled Product

CAS: 65141-46-0

Formula: C₈H₉N₃O₄

Color and Shape: Neat

Molecular weight: 211.17

Ref: TR-N398500

Nicorandil

CAS: 65141-46-0

Nicorandil is an ATP-dependent potassium channel activator. It activates mitochondrial ATP-dependent potassium (KATP) channels and inhibits the TLR4/MyD88/NF-κB/NLRP3 pathway, which reduces myocardial infarction-induced pyroptosis. Pyroptosis is an inflammatory cell death process that regulates cardiomyocyte loss after myocardial infarction. These findings suggest that nicorandil may be a potential therapy for ischemic heart disease due to its cardioprotective effects.

Formula: C₈H₉N₃O₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 211.17 g/mol

Ref: 3D-FN15906

Nicorandil - Bio-X ™

CAS: 65141-46-0

Nicorandil is an ATP-dependent potassium channel activator. It activates mitochondrial ATP-dependent potassium (KATP) channels and inhibits the TLR4/MyD88/NF-κB/NLRP3 pathway, which reduces myocardial infarction-induced pyroptosis. Pyroptosis is an inflammatory cell death process that regulates cardiomyocyte loss after myocardial infarction. These findings suggest that nicorandil may be a potential therapy for ischemic heart disease due to its cardioprotective effects.

Formula: C₈H₉N₃O₄

Purity: (%) Min. 95%

Color and Shape: Powder

Molecular weight: 211.17 g/mol

Ref: 3D-BN164649

2-[(pyridin-3-yl)formamido]ethyl nitrate

CAS: 65141-46-0

Formula: C₈H₉N₃O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 211.177

Ref: 10-F521158