CAS 65277-42-1: Ketoconazole

Description: Ketoconazole is an antifungal medication primarily used to treat various fungal infections, including those affecting the skin and mucous membranes. It belongs to the class of imidazole derivatives and functions by inhibiting the synthesis of ergosterol, a critical component of fungal cell membranes, thereby disrupting their integrity and function. Ketoconazole is characterized by its relatively low solubility in water but is soluble in organic solvents, which influences its formulation in topical and oral dosage forms. The substance has a molecular formula that reflects its complex structure, which includes multiple rings and functional groups that contribute to its pharmacological activity. Ketoconazole is known for its broad-spectrum antifungal properties, making it effective against a variety of fungi, including dermatophytes and yeasts. However, its use has been associated with potential side effects, including hepatotoxicity and endocrine effects, leading to restrictions in its systemic use. As a result, it is often prescribed in topical formulations for localized infections or in specific cases where systemic treatment is warranted.

Formula: C₂₆H₂₈Cl₂N₄O₄

InChI: InChI=1/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/s2

InChI key: InChIKey=XMAYWYJOQHXEEK-MKNUCDGGNA-N

SMILES: O=C(N1CCN(C2=CC=C(OCC3OC(OC3)(C4=CC=C(Cl)C=C4Cl)CN5C=NC=C5)C=C2)CC1)C

Synonyms:

• 1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethanone
• 1-[4-(4-{[(2S,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethanone
• 1-[4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethanone
• 1-acetyl-4-(4-{[(2R)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine
• Brizoral
• Cis-1-Acetyl-4-(4-((2-(2,4-Dichlorophenyl)-2-(1H-Imidazol-1-Ylmethyl)-1,3-Dioxolan-4-Yl)Methoxy)Phenyl)Piperazine
• Ethanone, 1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]-, rel-
• Fungarest
• Fungoral
• Ketoconazol
• Ketoderm
• Ketoisdin
• Ketozoral
• Micosin
• Nizaral
• Nizoral
• Nizral
• Onofin K
• Orifungal M
• Panfungol
• Phytorol
• Piperazine, 1-acetyl-4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-, rel-
• Piperazine, 1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-, cis-
• R 41400
• Tocon
• cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine
• rel-1-[4-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]ethanone
• Ketoconazole

Ketoconazole

CAS: 65277-42-1

• Formula: C₂₆H₂₈Cl₂N₄O₄
• Purity: >98.0%(T)(HPLC)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 531.43

Ketoconazole, 98%

CAS: 65277-42-1

Ketoconazole is used to treat candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, …

• Formula: C₂₆H₂₈Cl₂N₄O₄
• Purity: 98%
• Color and Shape: White, Powder
• Molecular weight: 531.43

Ketoconazole impurity standard

CAS: 65277-42-167914-61-8

• Color and Shape: Off-White

Ketoconazole

CAS: 65277-42-1

• Formula: C₂₆H₂₈CI₂N₄O₄
• Purity: 100.0%
• Color and Shape: White
• Molecular weight: 726.02

Ketoconazole CRS

CAS: 65277-42-1

• Formula: C₂₆H₂₈Cl₂N₄O₄
• Color and Shape: Powder
• Molecular weight: 531.4309

Ketoconazole RS

CAS: 65277-42-1

• Formula: C₂₆H₂₈Cl₂N₄O₄
• Color and Shape: Powder
• Molecular weight: 531.4309

Ketoconazole

CAS: 65277-42-1

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

• Formula: C₂₆H₂₈Cl₂N₄O₄
• Color and Shape: White Off-White Powder
• Molecular weight: 530.14876

Piperazine, 1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-, cis-

CAS: 65277-42-1

• Formula: C₂₆H₂₈Cl₂N₄O₄
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 531.4309

Ketoconazole

CAS: 65277-42-1

Ketoconazole (R-41400), a CYP3A4 inhibitor, is an imidazole anti-fungal agent.

• Formula: C₂₆H₂₈Cl₂N₄O₄
• Purity: 99.53% - 99.62%
• Color and Shape: Crystals From 4-Methylpentanone Solid
• Molecular weight: 531.43

Ketoconazole

CAS: 65277-42-1

• Purity: 99%
• Molecular weight: 531.43g/mol

Ketoconazole

CAS: 65277-42-1

• Formula: C₂₆H₂₈Cl₂N₄O₄
• Color and Shape: White To Off-White Solid
• Molecular weight: 531.44

Ketoconazole

CAS: 65277-42-1

• Molecular weight: 531.43g/mol

Ketoconazole, EP grade

CAS: 65277-42-1

• Formula: C₂₆H₂₈Cl₂N₄O₄
• Purity: (Titration) 99.0 - 101.0 % (dried basis)
• Color and Shape: White to almost white powder
• Molecular weight: 531.43

Ketoconazole

CAS: 65277-42-1

• Formula: C₂₆H₂₈Cl₂N₄O₄
• Purity: ≥ 99.0% (anhydrous basis)
• Color and Shape: White to off-white crystalline powder
• Molecular weight: 531.43

(±)-Ketoconazole-d4(piperazine-3,3,5,5-d4) (cis--isomers)

CAS: 1398065-75-2 65277-42-1

• Purity: 98 atom % D
• Color and Shape: White To Off-White Solid
• Molecular weight: 535.46

Ketoconazole

CAS: 65277-42-1

• Formula: C₂₆H₂₈Cl₂N₄O₄
• Color and Shape: Neat
• Molecular weight: 531.43

Ketoconazole, 98%

CAS: 65277-42-1

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Formula: C₂₆H₂₈Cl₂N₄O₄
• Purity: 98%
• Color and Shape: Powder, White to light brown
• Molecular weight: 531.43

Ketoconazole

CAS: 65277-42-1

• Formula: C₂₆H₂₈Cl₂N₄O₄
• Color and Shape: Neat
• Molecular weight: 531.43

Ketoconazole

CAS: 65277-42-1

M02048 - Ketoconazole

• Formula: C₂₆H₂₈Cl₂N₄O₄
• Purity: >99%
• Color and Shape: Solid
• Molecular weight: 531.43

Ketoconazole

CAS: 65277-42-1

Applications Inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic …

• Formula: C₂₆H₂₈Cl₂N₄O₄
• Color and Shape: White To Off-White
• Molecular weight: 531.43