CAS 656247-17-5
:Nintedanib
Description:
Nintedanib is a small molecule tyrosine kinase inhibitor primarily used in the treatment of certain types of cancer and pulmonary diseases. It is characterized by its ability to inhibit multiple receptor tyrosine kinases, including those involved in angiogenesis, fibrosis, and tumor growth. The chemical formula of Nintedanib is C27H29N5O3, and it has a molecular weight of approximately 463.55 g/mol. Nintedanib is typically administered orally and is known for its moderate to high solubility in organic solvents, while being less soluble in water. The compound exhibits a complex structure featuring a bicyclic core, which contributes to its pharmacological activity. Its mechanism of action involves the blockade of signaling pathways that promote cell proliferation and survival, making it effective in conditions like non-small cell lung cancer and idiopathic pulmonary fibrosis. As with many pharmaceuticals, Nintedanib may have side effects, including gastrointestinal disturbances and liver enzyme elevations, necessitating careful monitoring during treatment.
Formula:C31H33N5O4
InChI:InChI=1/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-
InChI key:InChIKey=XZXHXSATPCNXJR-ZIADKAODSA-N
SMILES:C(\NC1=CC=C(N(C(CN2CCN(C)CC2)=O)C)C=C1)(=C\3/C=4C(NC3=O)=CC(C(OC)=O)=CC4)/C5=CC=CC=C5
Synonyms:- 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester, (3Z)-
- 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester, (3Z)-
- Bibf-1120
- Intedanib
- Methyl (Z)-3-[[[4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
- Vargatef
- methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
- Nintedanib
- 3-Z-[1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone
- Nintedanib impurity 1
- methyl (Z)-3-[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxylate
- methyl (3Z)-3-[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxylate
- 3-[(4-{Methyl-[2-(4-methyl-piperazin-1-yl)-acetyl]-amino}-phenylamino)-phenyl-methylene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester
- Nintedanib/Intedanib/Vargatef
- Nintedanib, Free Base, >99%
- methyl (3Z)-2-hydroxy-3-[({4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl}amino)(phenyl)methylidene]-3H-indole-6-carboxylate
- Vargatef (nintedanib)
- Nintedanib (BIBF 1120)
- BIBF-1120(Nintedanib,Vargatef)
- NTEDANIB
- (3Z)-2,3-dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1H-Indole-6-carboxylic acid methyl ester
- See more synonyms
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Found 18 products.
Nintedanib
CAS:Purity:97.0%Color and Shape:Solid, No data available.Molecular weight:539.635986328125(Z)-methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
CAS:Formula:C31H33N5O4Purity:99%Color and Shape:SolidMolecular weight:539.6248Ref: IN-DA00FBZI
neTo inquire100gTo inquire250gTo inquire500gTo inquire50mg27.00€100mg28.00€250mg37.00€5mg46.00€1g69.00€5g140.00€10g179.00€25g526.00€Nintedanib
CAS:Formula:C31H33N5O4Purity:>95.0%(T)(HPLC)Color and Shape:White to Yellow to Yellow green powder to crystalMolecular weight:539.64Nintedanib
CAS:Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylateFormula:C31H33N5O4Purity:99+%Molecular weight:539.62Nintedanib (free base)
CAS:Formula:C31H33N5O4Purity:≥ 99.0%Color and Shape:White to yellow or beige solidMolecular weight:539.62Nintedanib
CAS:Nintedanib (Intedanib) is a triple vascular kinase inhibitor that inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50=34/13/13 nM), FGFR1, FGFR2, and FGFR3 (IC50=69/37/Formula:C31H33N5O4Purity:98% - 99.92%Color and Shape:SolidMolecular weight:539.62Intedanib
CAS:Controlled ProductApplications It is an indolinone derivative potently blocking VEGF-, PDGF-, and FGF-receptor kinases; an indolinone as triple angiokinase inhibitors. An antitumor agent.
References Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)Formula:C31H33N5O4Color and Shape:NeatMolecular weight:539.62Nintedanib - Bio-X ™
CAS:Nintedanib is an anti-inflammatory and anti-cancer drug. It is used for treatment of idiopathic pulmonary fibrosis. Nintedanib is a prodrug that is rapidly converted to the active form nintedanib, which inhibits angiogenesis by interfering with the activation of vascular endothelial growth factor receptor 1 (VEGFR1).
Nintedanib is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formula:C31H33O4N5Purity:(%) Min. 95%Color and Shape:Yellow To Green-Yellow SolidMolecular weight:539.63 g/molNintedanib
CAS:Nintedanib is an anti-inflammatory and anti-cancer drug. It is used for treatment of idiopathic pulmonary fibrosis . Nintedanib Bio-X is a prodrug that is rapidly converted to the active form nintedanib, which inhibits angiogenesis by interfering with the activation of vascular endothelial growth factor receptor 1 (VEGFR1).Formula:C31H33O4N5Purity:Min. 95%Color and Shape:PowderMolecular weight:539.63 g/molNintedanib
CAS:Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylateFormula:C31H33N5O4Purity:98%Molecular weight:539.62
