CAS 65646-68-6: Fenretinide
Description:Fenretinide, also known as N-(4-hydroxyphenyl)retinamide, is a synthetic retinoid that is primarily studied for its potential therapeutic effects in cancer treatment and prevention. It is characterized by its ability to modulate gene expression and influence cellular differentiation and apoptosis, making it a subject of interest in oncology research. Fenretinide exhibits a unique mechanism of action, distinct from other retinoids, as it does not activate retinoic acid receptors in the same manner. Instead, it is thought to exert its effects through the induction of oxidative stress and the modulation of various signaling pathways. The compound is typically administered in a non-toxic dosage form, and its pharmacokinetics involve absorption, distribution, metabolism, and excretion processes that are crucial for its efficacy. Fenretinide has shown promise in clinical trials for certain types of cancer, particularly breast cancer, and is being investigated for its potential use in other malignancies. Its safety profile and side effects are also important considerations in ongoing research.
Formula:C26H33NO2
InChI:InChI=1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24,4)5)8-6-9-20(2)18-25(29)27-22-12-14-23(28)15-13-22/h6,8-9,11-16,18,28H,7,10,17H2,1-5H3,(H,27,29)/b9-6+,16-11+,19-8+,20-18+
InChI key:InChIKey=AKJHMTWEGVYYSE-FXILSDISSA-N
SMILES:O=C(C=C(C=CC=C(C=CC1=C(C)CCCC1(C)C)C)C)NC2=CC=C(O)C=C2
- Synonyms:
- (4-Hydroxyphenyl)retinamide
- 15-[(4-Hydroxyphenyl)Amino]Retinal
- 4-Hpr
- Fenretinide
- Mk 4016
- N-(4-hydroxyphenyl)all-trans retinamide
- RII retinamide
- Retinamide, N-(4-hydroxyphenyl)-
- Retinoic acid p-hydroxyanilide
- Retinoic acid p-hydroxyphenylamide
- See more synonyms
- Ro 22-4667
- all-trans-4′-Hydroxyretinanilide
- all-trans-N-(4-hydroxyphenyl)retinamide
- N-(4-Hydroxyphenyl)retinamide
