CAS 65646-68-6

Fenretinide

Description:

Fenretinide, also known as N-(4-hydroxyphenyl)retinamide, is a synthetic retinoid that is primarily studied for its potential therapeutic effects in cancer treatment and prevention. It is characterized by its ability to modulate gene expression and influence cellular differentiation and apoptosis, making it a subject of interest in oncology research. Fenretinide exhibits a unique mechanism of action, distinct from other retinoids, as it does not activate retinoic acid receptors in the same manner. Instead, it is thought to exert its effects through the induction of oxidative stress and the modulation of various signaling pathways. The compound is typically administered in a non-toxic dosage form, and its pharmacokinetics involve absorption, distribution, metabolism, and excretion processes that are crucial for its efficacy. Fenretinide has shown promise in clinical trials for certain types of cancer, particularly breast cancer, and is being investigated for its potential use in other malignancies. Its safety profile and side effects are also important considerations in ongoing research.

Formula: C₂₆H₃₃NO₂

InChI: InChI=1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24,4)5)8-6-9-20(2)18-25(29)27-22-12-14-23(28)15-13-22/h6,8-9,11-16,18,28H,7,10,17H2,1-5H3,(H,27,29)/b9-6+,16-11+,19-8+,20-18+

InChI key: InChIKey=AKJHMTWEGVYYSE-FXILSDISSA-N

SMILES: C(=C/C(=C/C=C/C(=C/C(NC1=CC=C(O)C=C1)=O)/C)/C)\C=2C(C)(C)CCCC2C

Synonyms:

• (4-Hydroxyphenyl)retinamide
• 15-[(4-Hydroxyphenyl)Amino]Retinal
• 4-Hpr
• Fenretinide
• Mk 4016
• N-(4-hydroxyphenyl)all-trans retinamide
• RII retinamide
• Retinamide, N-(4-hydroxyphenyl)-
• Retinoic acid p-hydroxyanilide
• Retinoic acid p-hydroxyphenylamide
• Ro 22-4667
• all-trans-4′-Hydroxyretinanilide
• all-trans-N-(4-hydroxyphenyl)retinamide

all-trans-N-(4-Hydroxyphenyl)retinamide

CAS: 65646-68-6

Formula: C₂₆H₃₃NO₂

Purity: >98.0%(HPLC)

Color and Shape: White to Yellow to Orange powder to crystal

Molecular weight: 391.56

Ref: 3B-H1464

N-(4-Hydroxyphenyl)retinamide

CAS: 65646-68-6

Formula: C₂₆H₃₃NO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 391.5457

Ref: IN-DA003QL2

Fenretinide

CAS: 65646-68-6

Fenretinide

Purity: ≥98%

Molecular weight: 391.55g/mol

Ref: 54-BUP10695

Fenretinide

CAS: 65646-68-6

Formula: C₂₆H₃₃NO₂

Color and Shape: Yellow Solid

Molecular weight: 391.56

Ref: 4Z-F-075001

Fenretinide

CAS: 65646-68-6

Fenretinide

Formula: C₂₆H₃₃NO₂

Purity: >99%

Color and Shape: yellow solid

Molecular weight: 391.55g/mol

Ref: 54-BIFK0053

Fenretinide

CAS: 65646-68-6

Fenretinide (4-HPR) is an orally-active synthetic retinoid derivative with potential antineoplastic and chemopreventive activities.

Formula: C₂₆H₃₃NO₂

Purity: 98% - 99.68%

Color and Shape: Yellow Powder

Molecular weight: 391.55

Ref: TM-T1872

Fenretinide

CAS: 65646-68-6

Formula: C₂₆H₃₃NO₂

Purity: ≥ 98.0%

Color and Shape: Yellow to yellow-orange powder

Molecular weight: 391.55

Ref: 7W-GP8861

Fenretinide

Controlled Product

CAS: 65646-68-6

Stability Light Sensitive - Protect from Light Exposure
Applications Fenretinide (4-HPR) is a synthetic retinoid deriverative. 4-HBR is shown to exhibit binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death.A synthetic analog of Vitamin A.
References Marth, C., et al.:J. Nat. Cancer Inst., 75, 871 (1985), Delia, D., et al.: Cancer Res., 53, 6036 (1993), Costa., A., et al.: Cancer Res., 54, Suppl., 2032s (1994), Decensi., A., et al.: Eur. J. Cancer Prev., 3, 377 (1994)

Formula: C₂₆H₃₃NO₂

Color and Shape: Neat

Molecular weight: 391.55

Ref: TR-F250000

Fenretinide

CAS: 65646-68-6

Modulator of RBP protein; activator of sphingomyelinase; pro-apoptotic

Formula: C₂₆H₃₃NO₂

Purity: Min. 95%

Color and Shape: Yellow Solid

Molecular weight: 391.55 g/mol

Ref: 3D-FF23268

FENRETINIDE

CAS: 65646-68-6

Formula: C₂₆H₃₃NO₂

Purity: 98%

Molecular weight: 391.555

Ref: 10-F468334

Fenretinide-d4

Controlled Product

CAS: 65646-68-6

Applications Fenretinide-d4, is the labeled analogue of Fenretinide (F250000), which is a synthetic analog of Vitamin A.
References Marth, C., et al.: J. Nat. Cancer Inst., 75, 871 (1985), Delia, D., et al.: Cancer Res., 53, 6036 (1993), Costa., A., et al.: Cancer Res., 54, Suppl., 2032s (1994), Decensi., A., et al.: Eur. J. Cancer Prev., 3, 377 (1994)

Formula: C₂₆D₄H₂₉NO₂

Color and Shape: Neat

Molecular weight: 395.57

Ref: TR-F250002

Fenretinide

CAS: 65646-68-6

Formula: C₂₆H₃₃NO₂

Molecular weight: 391.56

Ref: ST-EA-CP-F142005