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CAS 6591-63-5

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quinidine sulfate dihydrate

Description:
Quinidine sulfate dihydrate is a chemical compound that serves primarily as an antiarrhythmic agent, used in the treatment of certain types of cardiac arrhythmias. It is a salt formed from quinidine, an alkaloid derived from the bark of the cinchona tree, and sulfuric acid, with the addition of two water molecules in its dihydrate form. This compound typically appears as a white to off-white crystalline powder and is soluble in water, which facilitates its use in pharmaceutical formulations. Quinidine sulfate dihydrate acts by blocking sodium channels and has a moderate effect on potassium channels, thereby influencing cardiac action potentials. Its pharmacological properties include the ability to prolong the QT interval, which is a critical aspect to monitor due to potential side effects such as torsades de pointes, a type of life-threatening arrhythmia. Additionally, it may exhibit antimalarial properties, although its primary use remains in cardiology. Proper dosing and monitoring are essential to minimize adverse effects and ensure therapeutic efficacy.
Formula:C40H54N4O10S
InChI:InChI=1/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14-,19+,20-;;;/m00.../s1
Synonyms:
  • Quinidine sulfate salt dihydrate
  • (9S)-6'-methoxycinchonan-9-ol sulfate hydrate (2:1:2)
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