CAS 66148-18-3

2,3,4,6-tetradeuterio-5-pyrrolidin-2-yl-pyridine

Description:

2,3,4,6-Tetradeuterio-5-pyrrolidin-2-yl-pyridine is a deuterated derivative of pyridine, a heterocyclic aromatic compound. The presence of deuterium, a stable isotope of hydrogen, in the molecule enhances its stability and alters its physical properties compared to its non-deuterated counterpart. This compound features a pyridine ring substituted with a pyrrolidine group, which introduces a five-membered nitrogen-containing ring, contributing to its unique chemical behavior. The deuterium substitution can affect the compound's reactivity, particularly in kinetic isotope effects, making it useful in studies involving reaction mechanisms and molecular dynamics. Additionally, the presence of multiple deuterium atoms can enhance the compound's solubility in certain solvents and influence its spectroscopic properties, such as NMR. This compound is primarily used in research settings, particularly in the fields of medicinal chemistry and pharmacology, where it may serve as a tracer or in the development of pharmaceuticals. Its specific applications and characteristics can vary based on the context of its use in scientific studies.

Formula: C₉H₈D₄N₂

InChI: InChI=1/C9H12N2/c1-3-8(7-10-5-1)9-4-2-6-11-9/h1,3,5,7,9,11H,2,4,6H2/i1D,3D,5D,7D

SMILES: c1(c(c(c(nc1[2H])[2H])C1CCCN1)[2H])[2H]

Synonyms:

• 3-(Pyrrolidin-2-yl)(< sup> 2< /sup> H< sub> 4< /sub> )pyridine
• Pyridine-2,3,4,6-D< Sub> 4< /Sub> , 5-(2-Pyrrolidinyl)-

(+/-)-Nornicotine-2,4,5,6-d4(pyridine-d4)

CAS: 66148-18-3

Purity: 98 atom % D

Color and Shape: Colorless Liquid

Molecular weight: 152.23

Ref: 3U-D4174

Nornicotine-d4

CAS: 66148-18-3

Formula: C₉H₈D₄N₂

Molecular weight: 152.23

Ref: 4Z-N-0611

(R,S)-Nornicotine-d4

Controlled Product

CAS: 66148-18-3

Stability Light Sensitive
Applications Labelled (RS)-Nornicotine (N757000). (RS)-Nornicotine is a tobacco alkaloid and the major Nicotine (N412420) metabolite in brain. Nornicotine appears to activate different nAChR subtypes, has a better pharmacokinetic profile, and produces less toxicity than Nicotine. Nornicotine shows a significant analgesic activity.
References Hecht, S., et al.: Carcinogenesis, 9, 875 (1988), Rivenson, A., et al.: Cancer Res., 48, 6912 (1988), Hoffmann, D., et al.: Chem. Res. Toxicol., 14, 767 (2001), Kool, J., et al.: J. Med. Chem., 49, 3287 (2006), Kool, J., et al.: Drug Metab. Dispos., 35, 640 (2007),

Formula: C₉₂H₄H₈N₂

Color and Shape: Colourless To Light Yellow

Molecular weight: 152.23

Ref: TR-N757010

(R,S)-Nornicotine-d4 (100 ug/mL in Methanol)

Controlled Product

CAS: 66148-18-3

Formula: C₉₂H₄H₈N₂

Color and Shape: Single Solution

Molecular weight: 152.23

Ref: TR-KIT0562