CAS 668467-91-2

1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-,3-(O-acetyloxime)

Description:

1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-,3-(O-acetyloxime) is a synthetic organic compound characterized by its indole core structure, which is a bicyclic compound consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring. This compound features a chloro substituent at the 5-position and an acetyloxime functional group at the 3-position, contributing to its reactivity and potential biological activity. The presence of the 2,5-dichlorophenyl group enhances its lipophilicity and may influence its interaction with biological targets. The compound is likely to exhibit properties typical of indole derivatives, such as potential antimicrobial, anti-inflammatory, or anticancer activities, although specific biological activities would need to be confirmed through empirical studies. Its molecular structure suggests it may participate in various chemical reactions, including nucleophilic substitutions and cycloadditions, making it of interest in medicinal chemistry and drug development. Safety and handling precautions should be observed due to the presence of chlorine substituents, which can impart toxicity.

Formula: C₁₇H₁₁Cl₃N₂O₃

InChI: InChI=1S/C17H11Cl3N2O3/c1-9(23)25-21-16-13-7-12(19)3-5-15(13)22(17(16)24)8-10-6-11(18)2-4-14(10)20/h2-7H,8H2,1H3/b21-16-

InChI key: OPQRFPHLZZPCCH-PGMHBOJBSA-N

SMILES: CC(=O)O/N=C\1/C2=C(C=CC(=C2)Cl)N(C1=O)CC3=C(C=CC(=C3)Cl)Cl

LDN-57444

CAS: 668467-91-2

Formula: C₁₇H₁₁Cl₃N₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 397.6398

Ref: IN-DA00FBJ5

LDN-57444

CAS: 668467-91-2

LDN-57444

Formula: C₁₇H₁₁Cl₃N₂O₃

Purity: ≥95%

Molecular weight: 397.64

Ref: 54-BUP05662

LDN-57444

CAS: 668467-91-2

Formula: C₁₇H₁₁Cl₃N₂O₃

Molecular weight: 397.64

Ref: 7W-GL0531

LDN-57444

CAS: 668467-91-2

LDN-57444 is a reversible, competitive proteasome Uch-L1 inhibitor(IC50=0.88 μM) .

Formula: C₁₇H₁₁Cl₃N₂O₃

Purity: 97.8% - 99.96%

Color and Shape: Yellow Solid

Molecular weight: 397.64

Ref: TM-T1924

LDN-57444

CAS: 668467-91-2

3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one

Formula: C₁₇H₁₁Cl₃N₂O₃

Purity: 98%

Molecular weight: 397.64

Ref: IN-DG630813

3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one

CAS: 668467-91-2

Purity: 98%

Molecular weight: 397.6400146

Ref: 10-F870120

LDN-57444

CAS: 668467-91-2

LDN-57444 is a monoclonal antibody that targets the epidermal growth factor receptor (EGFR) and inhibits its activation. LDN-57444 is being developed for the treatment of squamous cell carcinoma, which is a type of skin cancer. The drug has been shown to inhibit tumor growth in animal models by inhibiting body formation, promoting autophagy, and reducing mitochondrial membrane potential. LDN-57444 has also been shown to inhibit the proliferation of human cancer cells in vitro and decrease cardiac arrhythmias. LDN-57444 binds to EGFR with a hydroxyl group on its structure that interacts with the EGFR's active site. This binding prevents EGFR from activating downstream signaling pathways, such as those involving phosphatidylinositol 3-kinase (PI3K) and Akt kinase, which are involved in cell proliferation and survival.

Formula: C₁₇H₁₁Cl₃N₂O₃

Purity: Min. 95%

Molecular weight: 397.64 g/mol

Ref: 3D-TBB46791