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CAS 66966-09-4

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4-Methylumbelliferyl α-L-iduronide

Description:
4-Methylumbelliferyl α-L-iduronide is a synthetic chemical compound primarily used as a substrate in biochemical assays, particularly for the detection of iduronidase activity. It is a derivative of 4-methylumbelliferone, which is a fluorescent compound, making it useful in various enzymatic studies. The presence of the α-L-iduronide moiety allows it to be specifically cleaved by iduronidase, releasing the fluorescent 4-methylumbelliferone, which can be quantitatively measured. This property is particularly valuable in clinical diagnostics for lysosomal storage disorders, such as mucopolysaccharidosis type I. The compound is typically characterized by its solubility in water and organic solvents, and it exhibits fluorescence under UV light, facilitating its use in laboratory settings. Safety data sheets should be consulted for handling and storage guidelines, as with any chemical substance. Overall, 4-Methylumbelliferyl α-L-iduronide serves as an important tool in enzymology and medical research, aiding in the understanding of metabolic pathways and disease mechanisms.
Formula:C16H16O9
InChI:InChI=1S/C16H16O9/c1-6-4-10(17)24-9-5-7(2-3-8(6)9)23-16-13(20)11(18)12(19)14(25-16)15(21)22/h2-5,11-14,16,18-20H,1H3,(H,21,22)/t11-,12-,13+,14+,16+/m0/s1
InChI key:InChIKey=ARQXEQLMMNGFDU-ZHMBSYLPSA-N
SMILES:CC=1C=2C(=CC(O[C@@H]3O[C@@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]3O)=CC2)OC(=O)C1
Synonyms:
  • 4-Methyl-2-oxo-2H-1-benzopyran-7-yl alpha-L-ido-pyranosiduronic acid
  • 4-Methyl-2-oxo-2H-1-benzopyran-7-yl α-<span class="text-smallcaps">L</span>-idopyranosiduronic acid
  • 4-Methylumbelliferyl iduronide
  • 4-Methylumbelliferyl α-<span class="text-smallcaps">L</span>-idopyranosiduronic acid
  • 4-Methylumbelliferyl α-<span class="text-smallcaps">L</span>-iduronide
  • 4-methyl-2-oxo-2H-chromen-7-yl alpha-L-idopyranosiduronic acid
  • alpha-L-Idopyranosiduronic acid, 4-methyl-2-oxo-2H-1-benzopyran-7-yl
  • α-<span class="text-smallcaps">L</span>-Idopyranosiduronic acid, 4-methyl-2-oxo-2H-1-benzopyran-7-yl
  • 4-Methylumbelliferyl α-L-iduronide
  • 4-Methyl-2-oxo-2H-1-benzopyran-7-yl α-L-idopyranosiduronic acid
  • See more synonyms
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