CAS 67035-22-7

Dehydronifedipine

Description:

Dehydronifedipine is a chemical compound that belongs to the class of dihydropyridine calcium channel blockers, primarily used in the treatment of hypertension and angina. It is a derivative of nifedipine, characterized by the absence of a hydrogen atom at a specific position in its molecular structure, which influences its pharmacological properties. The compound typically exhibits a lipophilic nature, allowing for good membrane permeability, which is essential for its action on vascular smooth muscle cells. Dehydronifedipine functions by inhibiting calcium influx through voltage-gated calcium channels, leading to vasodilation and a subsequent decrease in blood pressure. Its pharmacokinetics may include a relatively rapid onset of action, with a duration that can vary based on formulation. Additionally, like other dihydropyridines, it may have side effects such as peripheral edema, flushing, and palpitations. As with any medication, its use should be guided by a healthcare professional, considering potential interactions and contraindications.

Formula: C₁₇H₁₆N₂O₆

InChI: InChI=1S/C17H16N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8H,1-4H3

InChI key: InChIKey=UMQHJQGNGLQJPF-UHFFFAOYSA-N

SMILES: C(OC)(=O)C=1C(=C(C(OC)=O)C(C)=NC1C)C2=C(N(=O)=O)C=CC=C2

Synonyms:

• 3,5-Pyridinedicarboxylic Acid, 2,6-Dimethyl-4-(2-Nitrophenyl)-, Dimethyl Ester
• 3,5-Pyridinedicarboxylic acid, 2,6-dimethyl-4-(2-nitrophenyl)-, 3,5-dimethyl ester
• B 4759
• BAY-b 4759
• Dehydronifedipine
• Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate
• Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylate

NIFEDIPINE IMPURITY A CRS

CAS: 67035-22-7

NIFEDIPINE IMPURITY A CRS

Formula: C₁₇H₁₆N₂O₆

Molecular weight: 344.3187

Ref: 41-N0750010

Dimethyl-2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylate

CAS: 67035-22-7

Dimethyl-2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylate

Color and Shape: Light Yellow

Ref: 47-865

Nifedipine Nitrophenylpyridine Analog (Dimethyl 4-(2-nitrophenyl)-2,6-dimethylpyridine-3,5-dicarboxylate)

CAS: 67035-22-7

Compounds containing an unfused pyridine ring in the structure, nesoi

Formula: C₁₇H₁₆N₂O₆

Color and Shape: White Yellow Powder

Molecular weight: 344.10084

Ref: 45-1463600

Dehydro Nifedipine

CAS: 67035-22-7

Dehydro Nifedipine (BAY-b 4759), main human plasma nifedipine metabolite, blocks glucose in PC-12 cells, IC50 at 130 μM, forms via CYP3A4/3A5.

Formula: C₁₇H₁₆N₂O₆

Purity: 99.51%

Color and Shape: Solid

Molecular weight: 344.32

Ref: TM-T36665

4-(2-Nitrophenyl)-2,6-dimethylpyridine-3,5-dicarboxylic acid dimethyl ester

CAS: 67035-22-7

Formula: C₁₇H₁₆N₂O₆

Purity: 99%

Color and Shape: Solid

Molecular weight: 344.3187

Ref: IN-DA005RBM

Nifedipine EP Impurity A (Dehydro Nifedipine)

CAS: 67035-22-7

Formula: C₁₇H₁₆N₂O₆

Color and Shape: Pale Yellow Solid

Molecular weight: 344.32

Ref: 4Z-N-074

Dehydro Nifedipine

CAS: 67035-22-7

Dehydro Nifedipine

Purity: ≥98%

Molecular weight: 344.32g/mol

Ref: 54-BUP14388

Nifedipine, oxidised

CAS: 67035-22-7

Formula: C₁₇H₁₆N₂O₆

Molecular weight: 344.32

Ref: 7W-GL8764

Dehydronifedipine

CAS: 67035-22-7

Formula: C₁₇H₁₆N₂O₆

Color and Shape: Neat

Molecular weight: 344.32

Ref: 04-C12116200

Dimethyl 2,6-Dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylate (Nitrophenylpyridine Analogue of Nifedipine)

Controlled Product

CAS: 67035-22-7

Formula: C₁₇H₁₆N₂O₆

Color and Shape: Neat

Molecular weight: 344.32

Ref: 86-MM0003.02

Dehydronifedipine 100 µg/mL in Acetonitrile

CAS: 67035-22-7

Formula: C₁₇H₁₆N₂O₆

Color and Shape: Single Solution

Molecular weight: 344.32

Ref: 04-A12116200AL-100

Nifedipine EP Impurity A

CAS: 67035-22-7

Formula: C₁₇H₁₆N₂O₆

Molecular weight: 344.32

Ref: ST-EA-CP-N9001

Dehydro Nifedipine

Controlled Product

CAS: 67035-22-7

Impurity Nifedipine EP Impurity A
Applications The main Nifedipine metabolite in human plasma.This compound is a contaminant of emerging concern (CECs).
References Guengerich, F., et al.: J. Biol. Chem., 261, 5051 (1986), Bork, R., et al.: J. Biol. Chem., 264, 910 (1989), Kerla, V., et al.: Biochem. Pharmacol., 44, 1745 (1992),

Formula: C₁₇H₁₆N₂O₆

Color and Shape: Light Yellow

Molecular weight: 344.32

Ref: TR-D229800

Dehydro nifedipine

CAS: 67035-22-7

Dehydronifedipine is a drug used for the treatment of hypertension. It is a prodrug that is converted in vivo to nifedipine, its active form. Dehydronifedipine has been shown to have inhibitory effects on rat liver microsomes and human serum. It has also been shown to be transported by the drug transporter p-glycoprotein (p-gp). Dehydronifedipine binds covalently to cytochrome P450 enzymes and inhibits their activity. This inhibition may lead to decreased metabolism of other drugs, leading to toxicities or adverse reactions. The levels of dehydronifedipine in plasma can be determined with an LC-MS/MS method. The concentration–time curve for this drug can be used to determine the time needed for half of the drug dose to be eliminated from the body, which is important when considering the appropriate dosing regimen for this medication.

Formula: C₁₇H₁₆N₂O₆

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 344.32 g/mol

Ref: 3D-FD20925