CAS 674289-55-5

1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one

Description:

1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one, identified by its CAS number 674289-55-5, is a complex organic compound characterized by its unique bicyclic structure that incorporates both pyrrole and quinoline moieties. This compound features a tetrahydro configuration, indicating the presence of a saturated ring system, along with a hydroxyl group that contributes to its potential reactivity and solubility in polar solvents. The methyl and phenyl substituents enhance its hydrophobic characteristics, which may influence its biological activity and interaction with other molecules. Such compounds are often of interest in medicinal chemistry due to their potential pharmacological properties, including anti-inflammatory or anticancer activities. The specific stereochemistry and functional groups present in this molecule can significantly affect its biological interactions and therapeutic efficacy. As with many organic compounds, the stability, solubility, and reactivity can vary based on environmental conditions, making it essential to consider these factors in practical applications.

Formula: C₁₈H₁₆N₂O₂

InChI: InChI=1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3

InChI key: InChIKey=LZAXPYOBKSJSEX-UHFFFAOYSA-N

SMILES: OC12C(N(CC1)C3=CC=CC=C3)=NC=4C(C2=O)=CC(C)=CC4

Synonyms:

• 4H-Pyrrolo[2,3-b]quinolin-4-one, 1,2,3,3a-tetrahydro-3a-hydroxy-6-methyl-1-phenyl-
• Blebbistatin
• (±)-Blebbistatin
• 1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one

Blebbistatin

CAS: 674289-55-5

Blebbistatin

Formula: C₁₈H₁₆N₂O₂

Purity: ≥98%

Molecular weight: 292.33

Ref: 54-BUP07238

(+/-)-Blebbistatin

CAS: 674289-55-5

Formula: C₁₈H₁₆N₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 292.3318

Ref: IN-DA0032AZ

(+/-)-Blebbistatin

Controlled Product

CAS: 674289-55-5

Applications Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. It blocks both blebbing and cytokinesis at 50-100µM.(±)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-oneSelective inhibitor of nonmuscle myosin II; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.
References Straight, A.F., et al.: Science, 299, 1743 (2003), Duxbury, M.S., et al.: Biochem. Biophys. Res. Commun., 313, 992 (2004), Kovacs, M., et al.: J. Biol. Chem., 279, 34 35557 (2004)

Formula: C₁₈H₁₆N₂O₂

Color and Shape: Neat

Molecular weight: 292.33

Ref: TR-B592490

Blebbistatin

CAS: 674289-55-5

3a-Hydroxy-6-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one

Formula: C₁₈H₁₆N₂O₂

Purity: 98%

Molecular weight: 292.33

Ref: IN-DG628751

Blebbistatin

CAS: 674289-55-5

Blebbistatin ((±)-Blebbistatin) is a non-muscle myosin II (NMII)-selective and non-muscle myosin heavy chain 9 (MYH9)-specific inhibitor.Cost-effective and quality-assured.

Formula: C₁₈H₁₆N₂O₂

Purity: 99.49% - 99.97%

Color and Shape: Solid

Molecular weight: 292.33

Ref: TM-T21550

BLEBBISTATIN

CAS: 674289-55-5

Purity: 98%

Color and Shape: Solid

Molecular weight: 292.3380127

Ref: 10-F809501

(+/-)-Blebbistatin

CAS: 674289-55-5

Inactive enantiomer of the inhibitor of myosin II-ATPase

Formula: C₁₈H₁₆N₂O₂

Purity: Min. 95%

Molecular weight: 292.33 g/mol

Ref: 3D-FB18838