CAS 67810-56-4

des-tyr-1-gamma-endorphin

Description:

Des-Tyr-1-gamma-endorphin, identified by its CAS number 67810-56-4, is a peptide that belongs to the class of endogenous opioid peptides. It is derived from the larger precursor protein pro-opiomelanocortin (POMC) and is known for its role in modulating pain, stress, and emotional responses. This peptide is characterized by its specific amino acid sequence, which influences its binding affinity to opioid receptors, particularly the mu-opioid receptor. Des-Tyr-1-gamma-endorphin exhibits analgesic properties and is involved in the body's natural pain relief mechanisms. Its structure typically includes a series of amino acids linked by peptide bonds, and it may exhibit biological activity through various signaling pathways. The absence of the tyrosine residue at the N-terminus distinguishes it from other forms of gamma-endorphin, impacting its pharmacological profile. Research into des-Tyr-1-gamma-endorphin continues to explore its potential therapeutic applications in pain management and the treatment of mood disorders.

Formula: C₇₄H₁₂₂N₁₈O₂₅S

InChI: InChI=1/C74H122N18O25S/c1-36(2)29-47(66(108)88-57(38(5)6)70(112)90-59(40(8)96)71(113)85-49(74(116)117)30-37(3)4)84-69(111)52-20-16-27-92(52)73(115)60(41(9)97)91-63(105)44(21-23-53(77)98)81-67(109)50(34-93)86-61(103)43(19-14-15-26-75)80-62(104)45(22-24-56(101)102)82-68(110)51(35-94)87-72(114)58(39(7)95)89-64(106)46(25-28-118-10)83-65(107)48(31-42-17-12-11-13-18-42)79-55(100)33-78-54(99)32-76/h11-13,17-18,36-41,43-52,57-60,93-97H,14-16,19-35,75-76H2,1-10H3,(H2,77,98)(H,78,99)(H,79,100)(H,80,104)(H,81,109)(H,82,110)(H,83,107)(H,84,111)(H,85,113)(H,86,103)(H,87,114)(H,88,108)(H,89,106)(H,90,112)(H,91,105)(H,101,102)(H,116,117)/t39-,40-,41-,43+,44+,45+,46+,47+,48+,49+,50+,51+,52+,57+,58+,59+,60+/m1/s1

Synonyms:

• gamma-Endorphin, des-tyr(1)-
• 1-De-L-tyrosine-16a-L-leucine-alpha-endorphin (sheep)
• 1-De-tyr-gamma-endorphin
• Dtgammae
• beta-Lipotropin(62-77)
• beta-Lph(62-77)
• gamma-Endorphin, des-tyrosine(1)-
• alpha-Endorphin (sheep), 1-de-L-tyrosine-16a-L-leucine
• glycylglycyl-L-phenylalanyl-L-methionyl-L-threonyl-L-seryl-L-alpha-glutamyl-L-lysyl-L-seryl-L-glutaminyl-L-threonyl-L-prolyl-L-leucyl-L-valyl-L-threonyl-L-leucine
• Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu
• (Des-tyr(1))-gamma-endorphin

[Des-Tyr1]-γ-Endorphin

CAS: 67810-56-4

[Des-Tyr1]-gamma-Endorphin is a neuropeptide found in human cerebrospinal fluid. It exhibits antidepressant activity, helps eliminate active avoidance behaviors in rats, and reduces passive avoidance behaviors in these animals.

Formula: C₇₄H₁₂₂N₁₈O₂₅S

Color and Shape: Solid

Molecular weight: 1695.93

Ref: TM-TP2751