CAS 68181-17-9

N-Succinimidyl 3-(2-pyridyldithio)propionate

Description:

N-Succinimidyl 3-(2-pyridyldithio)propionate (often abbreviated as SPDP) is a chemical compound commonly used in bioconjugation and protein labeling applications. It features a succinimidyl ester functional group, which is reactive towards amines, allowing for the formation of stable amide bonds with proteins or other biomolecules. The presence of a 2-pyridyldithio group provides a unique disulfide linkage that can be cleaved under reducing conditions, making it useful for controlled release applications. SPDP is typically a white to off-white solid and is soluble in organic solvents such as dimethyl sulfoxide (DMSO) and dimethylformamide (DMF), but less soluble in water. Its reactivity and ability to form stable conjugates make it valuable in the fields of biochemistry and molecular biology, particularly for the development of targeted drug delivery systems and the study of protein interactions. Proper handling and storage conditions are essential to maintain its stability and reactivity.

Formula: C₁₂H₁₂N₂O₄S₂

InChI: InChI=1/C12H12N2O4S2/c15-10-4-5-11(16)14(10)18-12(17)6-8-19-20-9-3-1-2-7-13-9/h1-3,7H,4-6,8H2

InChI key: InChIKey=JWDFQMWEFLOOED-UHFFFAOYSA-N

SMILES: O(C(CCSSC1=CC=CC=N1)=O)N2C(=O)CCC2=O

Synonyms:

• (2,5-Dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate
• 1-{[3-(Pyridin-2-Yldisulfanyl)Propanoyl]Oxy}Pyrrolidine-2,5-Dione
• 2,5-Pyrrolidinedione, 1-(1-oxo-3-(2-pyridinyldithio)propoxy)-
• 3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester
• N-Hydroxysuccinimidyl 3-(2-pyridyldithio)propionate
• N-Succinimidyl 3-(2-pyridyldithio)propionate
• N-Succinimidyl 3-(pyridyldithio)propionate
• NSC 344485
• NSC 677449
• Propanoic acid, 3-(2-pyridinyldithio)-, 2,5-dioxo-1-pyrrolidinyl ester
• SPDP-OSu
• Spdp
• Succinimidyl 3-[(2-pyridyl)dithio]propionate
• Succinimidyl 3-[[(2-pyridyl)thio]thio]propionate
• 1-(1-Oxo-3-(2-pyridyldithio)propoxy)pyrrolidine-2,5-dione
• 3-[(2-Pyridyl)dithio]propionic acid succinimidyl ester
• 3-(2-PYRIDYLDITHIO)-PROPIONIC ACID-OSU
• 3-(2-PYRIDYLDITHIO)PROPIONIC ACID N-SUCCINIMIDYL ESTER
• 1-[1-Oxo-3-(2-pyridinyldithio)propyloxy]-2,5-pyrrolidinedione
• 3-(2-PYRIDYLDITHIO)PROPIONIC ACID*N-HYDR OXYSUCCINIM
• SUCCINIMIDYL 3-(2-PYRIDYLDITHIO)PROPIONATE
• 3-(2-Pyridyldithio)propionic acid 2,5-dioxo-1-pyrrolidinyl ester
• N-SUCCINIMIDYL-3-(2-PYRIDYLDITHIO)PROPIONANATE
• 3-(2-PYRIDYLDITHIO)-PROPIONIC ACID N-HYDROXYSUCCINIMIDE ESTER CRYSTALLINE
• 3-[(2-Pyridinyl)dithio]propionic acid succinimidyl ester
• N-[3-(2-Pyridyldithio)propionyloxy]succinimide
• 3-(Pyridin-2-yldisulfanyl)-propionic acid-OS
• N-Succinimidyl 3-(2-pyridyldithio)propionate, SPDP
• 3-(2-PYRIDYLDITHIO)PROPIONIC ACID N-HYDROXY-SUCCINIMIDE ESTER
• 3-(PYRIDIN-2-YLDISULFANYL)-PROPIONIC ACID-OSU

SPDP (2mg×5)

CAS: 68181-17-9

Formula: C₁₂H₁₂N₂O₄S₂

Color and Shape: White to Almost white powder to crystaline

Molecular weight: 312.36

Ref: 3B-P2814

N-Succinimidyl 3-(2-Pyridyldithio)propionate

CAS: 68181-17-9

Formula: C₁₂H₁₂N₂O₄S₂

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 312.36

Ref: 3B-S0819

3-(2-Pyridyldithio)-propionic acid-OSu

CAS: 68181-17-9

SPDP, important crosslinking reagent for the preparation of protein-protein and peptide-protein conjugates linked by disulfide bonds.

Formula: C₁₂H₁₂N₂O₄S₂

Purity: > 90%

Color and Shape: Colourless Liquid

Molecular weight: 312.37

Ref: 01-4029094

SPDP

CAS: 68181-17-9

Formula: C₁₂H₁₂N₂O₄S₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 312.3647

Ref: IN-DA006D74

N-Succinimidyl 3-(2-pyridyldithio)propionate

CAS: 68181-17-9

N-Succinimidyl 3-(2-pyridyldithio)propionate

Formula: C₁₂H₁₂N₂O₄S₂

Purity: 98%

Color and Shape: white powder

Molecular weight: 312.36g/mol

Ref: 54-BICL210

SPDP

CAS: 68181-17-9

SPDP

Purity: ≥98%

Molecular weight: 312.36g/mol

Ref: 54-BUP17998

SPDP

CAS: 68181-17-9

SPDP crosslinks amines to sulfhydryls, forms reducible bonds, and activates anti-CD11c/CTLA-4 Abs at pH 8.5.

Formula: C₁₂H₁₂N₂O₄S₂

Purity: >99.99%

Color and Shape: White Solid

Molecular weight: 312.36

Ref: TM-T6741

3-(2-Pyridyldithio)propionic Acid N-Succinimidyl Ester

CAS: 68181-17-9

Stability Hygroscopic, Moisture Sensitive
Applications A heterobifunctional cross-linker.
References Carlsson, J. et al.: Biochem. J., 173, 723 (1978), Neurath, A.R., and Strick, N.J.. : J. Virol. Meth., 3, 155 (1981)

Formula: C₁₂H₁₂N₂O₄S₂

Color and Shape: Neat

Molecular weight: 312.36

Ref: TR-P996850

3-(2-Pyridyldithio)propionic Acid N-Succinimidyl Ester

CAS: 68181-17-9

Formula: C₁₂H₁₂N₂O₄S₂

Ref: TR-TRC-P996850

SPDP

CAS: 68181-17-9

SPDP is a pyridyldithiol linker that forms reversible disulfide bonds with thiols. It allows the controlled release of biomolecules in reductive environments.

Formula: C₁₂H₁₂N₂O₄S₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 312.37 g/mol

Ref: 3D-FP27339

3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester

CAS: 68181-17-9

Formula: C₁₂H₁₂N₂O₄S₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 312.36

Ref: 10-F493199

3-(2-Pyridyldithio)propionic Acid N-Hydroxysuccinimide Ester (SPDP Crosslinker) extrapure, 95%

CAS: 68181-17-9

Formula: C₁₂H₁₂N₂O₄S₂

Purity: min. 95%

Color and Shape: White, Powder

Molecular weight: 312.36

Ref: SR-16315