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CAS 68181-17-9

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N-Succinimidyl 3-(2-pyridyldithio)propionate

Description:
N-Succinimidyl 3-(2-pyridyldithio)propionate (often abbreviated as SPDP) is a chemical compound commonly used in bioconjugation and protein labeling applications. It features a succinimidyl ester functional group, which is reactive towards amines, allowing for the formation of stable amide bonds with proteins or other biomolecules. The presence of a 2-pyridyldithio group provides a unique disulfide linkage that can be cleaved under reducing conditions, making it useful for controlled release applications. SPDP is typically a white to off-white solid and is soluble in organic solvents such as dimethyl sulfoxide (DMSO) and dimethylformamide (DMF), but less soluble in water. Its reactivity and ability to form stable conjugates make it valuable in the fields of biochemistry and molecular biology, particularly for the development of targeted drug delivery systems and the study of protein interactions. Proper handling and storage conditions are essential to maintain its stability and reactivity.
Formula:C12H12N2O4S2
InChI:InChI=1/C12H12N2O4S2/c15-10-4-5-11(16)14(10)18-12(17)6-8-19-20-9-3-1-2-7-13-9/h1-3,7H,4-6,8H2
InChI key:InChIKey=JWDFQMWEFLOOED-UHFFFAOYSA-N
SMILES:O(C(CCSSC1=CC=CC=N1)=O)N2C(=O)CCC2=O
Synonyms:
  • (2,5-Dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate
  • 1-{[3-(Pyridin-2-Yldisulfanyl)Propanoyl]Oxy}Pyrrolidine-2,5-Dione
  • 2,5-Pyrrolidinedione, 1-(1-oxo-3-(2-pyridinyldithio)propoxy)-
  • 3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester
  • N-Hydroxysuccinimidyl 3-(2-pyridyldithio)propionate
  • N-Succinimidyl 3-(2-pyridyldithio)propionate
  • N-Succinimidyl 3-(pyridyldithio)propionate
  • NSC 344485
  • NSC 677449
  • Propanoic acid, 3-(2-pyridinyldithio)-, 2,5-dioxo-1-pyrrolidinyl ester
  • See more synonyms
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