CAS 68377-91-3

Arotinolol hydrochloride

Description:

Arotinolol hydrochloride is a pharmaceutical compound primarily recognized for its role as a non-selective beta-adrenergic antagonist with additional alpha-adrenergic blocking properties. It is often utilized in the treatment of hypertension and certain cardiovascular conditions. The substance is characterized by its ability to lower blood pressure by inhibiting the effects of catecholamines on the heart and blood vessels, leading to decreased heart rate and vascular resistance. Arotinolol hydrochloride is typically administered in its hydrochloride salt form, which enhances its solubility and bioavailability. The compound is known to exhibit a moderate half-life, allowing for effective dosing regimens. In terms of safety and side effects, it may cause typical beta-blocker-related reactions, such as fatigue, dizziness, or bradycardia. As with many pharmaceuticals, its use should be monitored by healthcare professionals to manage potential interactions and contraindications effectively. Overall, Arotinolol hydrochloride represents a significant therapeutic option in the management of cardiovascular diseases.

Formula: C₁₅H₂₁N₃O₂S₃·ClH

InChI: InChI=1S/C15H21N3O2S3.ClH/c1-15(2,3)17-6-9(19)7-21-14-18-10(8-22-14)11-4-5-12(23-11)13(16)20;/h4-5,8-9,17,19H,6-7H2,1-3H3,(H2,16,20);1H

InChI key: InChIKey=XXDAXBZYUXLDRD-UHFFFAOYSA-N

SMILES: C(N)(=O)C=1SC(=CC1)C=2N=C(SCC(CNC(C)(C)C)O)SC2.Cl

Synonyms:

• 2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-, hydrochloride (1:1)
• 2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-, monohydrochloride
• 2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-, monohydrochloride, (S)-
• 5-(2-{[3-(Tert-Butylamino)-2-Hydroxypropyl]Sulfanyl}-1,3-Thiazol-4-Yl)Thiophene-2-Carboxamide
• Almarl
• Arotinolol Hcl
• S 596
• Arotinolol hydrochloride

Arotinolol HCl

CAS: 68377-91-3

Formula: C₁₅H₂₂ClN₃O₂S₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 408.0021

Ref: IN-DA00F9VU

Arotinolol HCl

CAS: 68377-91-3

Formula: C₁₅H₂₁N₃O₂S₃·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 371.53 36.46

Ref: 4Z-A-238001

Arotinolol hydrochloride

CAS: 68377-91-3

Arotinolol hydrochloride

Purity: ≥98%

Molecular weight: 408g/mol

Ref: 54-BUP08412

Arotinolol hydrochloride

CAS: 68377-91-3

Formula: C₁₅H₂₂ClN₃O₂S₃

Molecular weight: 408.00

Ref: 7W-GP8092

Arotinolol hydrochloride

CAS: 68377-91-3

Arotinolol HCl is a non-selective α/β-blocker, anti-hypertensive, anti-obesity, and improves aortic stiffness.

Formula: C₁₅H₂₂ClN₃O₂S₃

Purity: 99.84%

Color and Shape: Solid

Molecular weight: 408

Ref: TM-T30140

Arotinolol hydrochloride

CAS: 68377-91-3

Arotinolol hydrochloride is a beta-blocker that, in contrast to propranolol, has a higher selectivity for the β1 receptor. It is used to treat hypertension and angina pectoris. Arotinolol hydrochloride lowers blood pressure by inhibiting the activity of α-adrenergic receptors, which are found in the heart and vascular smooth muscle. This inhibition reduces the release of norepinephrine and causes vasodilation. Arotinolol hydrochloride also has a positive effect on cardiac function as it decreases myocardial oxygen demand and increases coronary flow. Arotinolol hydrochloride has been shown to lower systolic pressure in anesthetized dogs with an intravenous dose of sodium citrate. The drug also lowers diastolic pressure in conscious dogs at doses of 0.5 mg/kg (0.2 mg/lb) or greater when given intravenously or subcutaneously.

Formula: C₁₅H₂₂ClN₃O₂S₃

Purity: Min. 98%

Color and Shape: Powder

Molecular weight: 408 g/mol

Ref: 3D-FA146940

Arotinolol Hydrochloride

Controlled Product

CAS: 68377-91-3

Applications Arotinolol is both and alpha- and beta-adrenoceptor antagonist and is used to treat essential tremors and hypertension.
References Kuroda, Y., et al.: Neurology, 38, 650 (1988); Miyagishi, A., et al.: Arch. Pharmacodyn. Ther., 271, 249 (1984); Wu, H., et al.: Hypertens. Res.: Off. J. Jpn. Soc. Hypertens., 24, 605 (2001)

Formula: C₁₅H₂₁N₃O₂S₃·ClH

Color and Shape: Neat

Molecular weight: 408.002

Ref: TR-A771503