CAS 68767-14-6

Loxoprofen

Description:

Loxoprofen is a non-steroidal anti-inflammatory drug (NSAID) primarily used for its analgesic and anti-inflammatory properties. It is commonly employed in the treatment of pain and inflammation associated with conditions such as arthritis, muscle pain, and postoperative discomfort. Loxoprofen functions by inhibiting the cyclooxygenase (COX) enzymes, which play a crucial role in the synthesis of prostaglandins, compounds that mediate inflammation and pain. The substance is characterized by its relatively rapid onset of action and is often formulated in various dosage forms, including tablets and topical applications. Loxoprofen is known for its favorable gastrointestinal safety profile compared to some other NSAIDs, making it a preferred choice in certain clinical scenarios. However, like all medications, it may have side effects, including gastrointestinal disturbances, cardiovascular risks, and potential interactions with other drugs. Its chemical structure includes a propionic acid derivative, contributing to its pharmacological activity. As with any medication, it is essential to use Loxoprofen under medical supervision to ensure safety and efficacy.

Formula: C₁₅H₁₈O₃

InChI: InChI=1S/C15H18O3/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16/h5-8,10,13H,2-4,9H2,1H3,(H,17,18)

InChI key: InChIKey=YMBXTVYHTMGZDW-UHFFFAOYSA-N

SMILES: C(C1=CC=C(C(C(O)=O)C)C=C1)C2C(=O)CCC2

Synonyms:

• 2-[4-(2-Oxo-Cyclopentylmethyl)-Phenyl]-Propionic Acid
• 2-[4-[(2-Oxocyclopentan-1-Yl)Methyl]Phenyl]Propionic Acid
• 2-[4-[(2-Oxocyclopentyl)methyl]phenyl]propionic acid
• 2-{4-[(2-Oxocyclopentyl)Methyl]Phenyl}Propanoic Acid
• A-Methyl-4-[(2-Oxocyclopentyl)Methyl]Benzeneacetic Acid
• Alpha-Methyl-4-[(2-Oxocyclopentyl)Methyl]Benzeneacetic Acid
• Benzeneacetic acid, α-methyl-4-[(2-oxocyclopentyl)methyl]-
• Ioxoprofen
• Koloxo
• Loxoprofen Acid
• ��-Methyl-4-[(2-Oxocyclopentyl)Methyl]Benzeneacetic Acid

Loxoprofen

CAS: 68767-14-6

Formula: C₁₅H₁₈O₃

Purity: >97.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 246.31

Ref: 3B-L0244

Loxoprofen

CAS: 68767-14-6

Loxoprofen (Koloxo) is an anti-inflammatory non-steroidal medicine.

Formula: C₁₅H₁₈O₃

Purity: 98.59%

Color and Shape: White To Yellowish Crystalline Powder

Molecular weight: 246.3

Ref: TM-T0463

Loxoprofen

CAS: 68767-14-6

Formula: C₁₅H₁₈O₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 246.3016

Ref: IN-DA003RD6

Loxoprofen

CAS: 68767-14-6

Formula: C₁₅H₁₈O₃

Purity: ≥ 97.0%

Color and Shape: White to faint yellow crystalline powder

Molecular weight: 246.30

Ref: 7W-GP1810

Loxoprofen

CAS: 68767-14-6

Loxoprofen

Purity: ≥98%

Molecular weight: 246.3g/mol

Ref: 54-BUP15038

Loxoprofen

CAS: 68767-14-6

Loxoprofen

Purity: 98%

Molecular weight: 246.3g/mol

Ref: 54-OR1030277

Loxoprofen

CAS: 68767-14-6

Formula: C₁₅H₁₈O₃

Color and Shape: Off-White Solid

Molecular weight: 246.31

Ref: 4Z-L-891

Loxoprofen Impurity 1 and Loxoprofen Impurity 50

CAS: 68767-14-6

Formula: C₁₈H₂₄O₅

Molecular weight: 320.39

Ref: 4Z-L-8978

Loxoprofen-d4

CAS: 68767-14-6

Formula: C₁₅H₁₄D₄O₃

Color and Shape: White To Off-White Solid

Molecular weight: 250.33

Ref: 4Z-L-8921

Loxoprofen Sodium Salt Dihydrate

CAS: 226721-96-6, 68767-14-6, 80382-23-6

Formula: C₁₅H₁₇NaO₃·2H₂O

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 304.32

Ref: 3B-L0252

Loxoprofen-d6

CAS: 68767-14-6

Formula: C₁₅H₁₂D₆O₃

Molecular weight: 252.35

Ref: 4Z-L-897

Loxoprofen RS

CAS: 68767-14-6

Color and Shape: White Solid Crystalline Powder

Ref: 2K-1188000021

Loxoprofen

Controlled Product

CAS: 68767-14-6

Applications Loxoprofen is a non-selective nonsteroidal anti-inflammatory drug (NSAID) that has been effective in reducing atherosclerosis in mice by reducing inflammation. Loxoprofen becomes active after metabolism in the body and inhibits the activation of cyclooxygenase.
References Masahide H. et al.: J Clin Biochem Nutr., 47, 138 (2010); Noguchi, M. et al.: Biolog. Pharmac. Bull., 28, 2075 (2005); Hyun, J. et al.: Arch. Pharm. Res., 24, 541 (2001);

Formula: C₁₅H₁₈O₃

Color and Shape: White To Off-White

Molecular weight: 246.30

Ref: TR-L472905

Loxoprofen-d3

Controlled Product

CAS: 68767-14-6

Applications Loxoprofen-d3, is the labeled analogue of Loxoprofen (L472905), which is non-selective nonsteroidal anti-inflammatory drug (NSAID) that has been effective in reducing atherosclerosis in mice by reducing inflammation.
References Masahide H. et al.: J Clin Biochem Nutr., 47, 138 (2010); Noguchi, M. et al.: Biolog. Pharmac. Bull., 28, 2075 (2005); Hyun, J. et al.: Arch. Pharm. Res., 24, 541 (2001);

Formula: C₁₅H₁₅D₃O₃

Color and Shape: Neat

Molecular weight: 249.32

Ref: TR-L472907

Loxoprofen (low-melting polymorph)

CAS: 68767-14-6

Loxoprofen is a non-steroidal anti-inflammatory drug that belongs to the class of drugs called pyrazoles. It is used in the treatment of inflammation and pain caused by arthritis, osteoarthritis, gout, menstrual pain, and dental pain. Loxoprofen binds to cyclooxygenase (COX) enzymes, thereby inhibiting prostaglandin synthesis. The COX enzymes are necessary for the production of prostaglandins that lead to inflammation and pain. Loxoprofen also inhibits bacterial translocation by binding to bacterial lipopolysaccharides on the cell surface and preventing their interaction with immune cells. Loxoprofen has been shown to inhibit colony stimulating factor (CSF) activity in vitro assays by disrupting CSF-1 binding to its receptor erythropoietin receptor or CD11b/CD18 integrin receptors on monocytes or neutrophils. This means that it will not stimulate the

Formula: C₁₅H₁₈O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 246.3 g/mol

Ref: 3D-FL172228

Loxoprofen (high-melting polymorph)

CAS: 68767-14-6

Loxoprofen is a nonsteroidal anti-inflammatory drug that belongs to the group of drugs called NSAIDs. It has potent inhibitory activity against growth factor, which is important for the promotion of inflammation and tissue damage in diseases such as rheumatoid arthritis. Loxoprofen has been shown to have strong inhibitory effects on bacterial translocation in mice with colitis, which may be related to its ability to decrease the expression of endogenous substances through inhibition of colony-stimulating factor. Loxoprofen also has a high solubility in water (2g/L) and is soluble in biocompatible polymers such as polyvinylpyrrolidone.

Formula: C₁₅H₁₈O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 246.31 g/mol

Ref: 3D-FL172231

Loxoprofen (high-melting polymorph)

CAS: 68767-14-6

Loxoprofen is a high-melting polymorph of loxoprofen, which is a nonsteroidal anti-inflammatory drug. Loxoprofen is used for the relief of pain and inflammation in patients with rheumatoid arthritis and osteoarthritis. It has been shown to be useful as an intermediate in the synthesis of other compounds, such as pharmaceuticals, pesticides, and dyes. Loxoprofen has also been found to be a useful building block in organic synthesis reactions that require high quality reagents.

Formula: C₁₅H₁₈O₃

Purity: Min. 98.5 Area-%

Molecular weight: 246.31 g/mol

Ref: 3D-Q-201324

2-(4-((2-Oxocyclopentyl)methyl)phenyl)propanoic acid

CAS: 68767-14-6

Formula: C₁₅H₁₈O₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 246.306

Ref: 10-F093438

Loxoprofen (low-melting polymorph)

CAS: 68767-14-6

Loxoprofen is a chemical intermediate that can be used to synthesize complex molecules. It has been shown to have many uses in the laboratory as a reaction component, reagent, or as a useful scaffold for research chemicals. Loxoprofen is also an effective building block for more complex compounds and can be used to synthesize speciality chemicals such as fine chemicals and pharmaceuticals. Loxoprofen is a white solid with low melting point that can be dissolved in organic solvents such as dichloromethane and chloroform.

Formula: C₁₅H₁₈O₃

Purity: Min. 98.5 Area-%

Molecular weight: 246.31 g/mol

Ref: 3D-Q-300011