CAS 6882-68-4

(-)-Sophoridine

Description:

(-)-Sophoridine is an alkaloid derived from the Sophora species, particularly noted for its presence in Sophora flavescens. It is characterized by its chiral nature, existing as a specific enantiomer with biological activity. The compound typically exhibits a white to off-white crystalline appearance and is soluble in organic solvents, though its solubility in water is limited. (-)-Sophoridine has garnered interest in pharmacology due to its potential therapeutic effects, including anti-inflammatory and neuroprotective properties. Its molecular structure features a complex arrangement of carbon, hydrogen, nitrogen, and oxygen atoms, contributing to its biological activity. The compound's mechanism of action and specific interactions within biological systems are subjects of ongoing research, highlighting its potential applications in medicine. As with many alkaloids, (-)-Sophoridine may also exhibit toxicity at certain concentrations, necessitating careful handling and dosage considerations in research and therapeutic contexts.

Formula: C₁₅H₂₄N₂O

InChI: InChI=1/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12-,13-,15+/m1/s1

InChI key: InChIKey=ZSBXGIUJOOQZMP-BHPKHCPMSA-N

SMILES: O=C1N2[C@@]([C@@]3([C@@]4([C@@](C2)(CCCN4CCC3)[H])[H])[H])(CCC1)[H]

Synonyms:

• (7aR,13aR,13bR,13cS)-Dodecahydro-1H,5H,10H-dipyrido[2,1-f:3′,2′,1′-ij][1,6]naphthyridin-10-one
• 1H,5H,10H-Dipyrido[2,1-f:3′,2′,1′-ij][1,6]naphthyridin-10-one, dodecahydro-, (7aR,13aR,13bR,13cS)-
• 1H,5H,10H-Dipyrido[2,1-f:3′,2′,1′-ij][1,6]naphthyridin-10-one, dodecahydro-, [7aR-(7aα,13aα,13bβ,13cβ)]-
• 5-Epidihydrosophocarpine
• Allomatrine
• Dihydro-5-episophocarpine
• Matridin-15-one, (5β)-
• Sophoridin
• l-Sophoridine
• Sophoridine
• (5-beta)-matridin-15-on
• Sordidness
• Sophoridine Powder
• (5-beta)-Matridin-15-one
• (7aR,13aR,13bR,13cS)-Dodecahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one
• Matridin-15-one, (5-beta)- (9ci)
• (41S,7aR,13aR,13bR)-Dodecahydro-1H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10(41H)-one
• I-SOPHORIDINE
• OPHORIDINE
• SOLSTITIALIN A 13-ACETATE(SH)(CALL)
• (5β)-Matridin-15-one
• Sophoridine, 98%, from Sophora alopecuroides L.
• 1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, dodecahydro-, (7aR,13aR,13bR,13cS)-
• Docusate Sodium Impurity 10

Sophoridin

CAS: 6882-68-4

Sophoridin

Formula: C₁₅H₂₄N₂O

Purity: >98%

Molecular weight: 248.36

Ref: 54-OR1029187

Sophoridine

CAS: 6882-68-4

Formula: C₁₅H₂₄N₂O

Purity: 96%

Color and Shape: Solid

Molecular weight: 248.3639

Ref: IN-DA00FA4S

Sophoridine

CAS: 6882-68-4

Formula: C₁₅H₂₄N₂O

Molecular weight: 248.37

Ref: 7W-GY8337

Sophoridine

CAS: 6882-68-4

Sophoridine

Formula: C₁₅H₂₄N₂O

Purity: ≥95%

Molecular weight: 248.36

Ref: 54-BUP00156

Sophoridine

CAS: 6882-68-4

Sophoridine has anti-inflammatory, anti-cancer and anti-arrhythmia, and affects the immune and central nervous systems. Early and short-time applying sophoridine has neuroprotective effect min permanent middle cerebral artery occlusion (pMCAO) rat brain by down-regulating TRAF6 and up-regulating p-ERK1/2 expression, ameliorating brain infaction and edema. Sophoridine also possesses antiviral activities against Coxsackievirus B3, by regulating cytokine expression, may represent a potential therapeutic agent for viral myocarditis.

Formula: C₁₅H₂₄N₂O

Purity: 95%~99%

Molecular weight: 248.37

Ref: BP-BP1327

Sophoridine

CAS: 6882-68-4

Formula: C₁₅H₂₄N₂O

Purity: >98.0%(GC)(T)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 248.37

Ref: 3B-M3093

Sophoridine

CAS: 6882-68-4

(41S,7aR,13aR,13bR)-Dodecahydro-1H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10(41H)-one

Formula: C₁₅H₂₄N₂O

Purity: 96%

Molecular weight: 248.36

Ref: IN-DG151746

Sophoridine

CAS: 6882-68-4

Sophoridine, a natural Chinese anticancer drug, has a potent derivative 6b targeting DNA topoisomerase I in tumor cells, inducing apoptosis.

Formula: C₁₅H₂₄N₂O

Purity: 97.33% - 99.28%

Color and Shape: White Solid

Molecular weight: 248.36

Ref: TM-T3339

Sophoridine

CAS: 6882-68-4

Natural alkaloid

Formula: C₁₅H₂₄N₂O

Purity: ≥ 90.0 % (HPLC)

Color and Shape: Crystalline

Molecular weight: 248.36

Ref: 5G-80540

(-)Sophoridine

Controlled Product

CAS: 6882-68-4

Applications (-)Sophoridine is an anticancer agent, with a promising anti-rumor effect and lower toxicity. Anti-inflammatory.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Liu, H. et al.: J. Chin. Chem. Soc., 61, 897 (2014); Huang, X. et al.: J. Anal. Meth. Chem., 502626, 7 (2014);

Formula: C₁₅H₂₄N₂O

Color and Shape: Neat

Molecular weight: 248.36

Ref: TR-S676840

Sophoridine

CAS: 6882-68-4

Sophoridine is a quinolizidine alkaloid from Chinese medicinal plant Sophora flavescens. The compound has anti-proliferative effects and inhibits growth of colorectal cancer cells and xenograft tumors. The compound is also a low potency blocker of hERG channel and is able to alter its activation properties. It has antiviral properties against Coxsackievirus B3, which is a causative agent of the viral myocarditis.

Formula: C₁₅H₂₄N₂O

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 248.36 g/mol

Ref: 3D-FS65812

Sophoridine

CAS: 6882-68-4

Formula: C₁₅H₂₄N₂O

Purity: ≥98%(GC)(T)

Molecular weight: 248.37

Ref: 10-F053776