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CAS 6901-13-9

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Lumicolchicine

Description:
Lumicolchicine, with the CAS number 6901-13-9, is a synthetic derivative of colchicine, a well-known alkaloid derived from the plant Colchicum autumnale. This compound exhibits characteristics similar to colchicine, primarily functioning as a microtubule inhibitor, which interferes with cell division by disrupting the mitotic spindle formation. Lumicolchicine is notable for its potential applications in cancer research and treatment, as it can induce apoptosis in rapidly dividing cells. The compound is typically characterized by its low solubility in water, which can affect its bioavailability and pharmacokinetics. Additionally, lumicolchicine has been studied for its effects on various cellular processes, including inflammation and cell signaling pathways. Safety and toxicity profiles are essential considerations in its application, as with many alkaloids, due to potential side effects. Overall, lumicolchicine represents a significant area of interest in medicinal chemistry, particularly in the development of targeted therapies for malignancies.
Formula:C22H25NO6
InChI:InChI=1/C22H25NO6/c1-10(24)23-13-7-6-11-8-15(27-3)21(28-4)22(29-5)16(11)17-12-9-14(26-2)20(25)18(12)19(13)17/h8-9,12-13,18H,6-7H2,1-5H3,(H,23,24)/t12?,13-,18?/m0/s1
InChI key:InChIKey=VKPVZFOUXUQJMW-FHSNZYRGSA-N
SMILES:N(C(C)=O)[C@@H]1C2=C([C@@]3([C@]2(C(=O)C(OC)=C3)[H])[H])C=4C(=CC(OC)=C(OC)C4OC)CC1
Synonyms:
  • (-)-β-Lumicolchicine
  • (7S-(7alpha,7bbeta,10abeta))-N-(5,6,7,7b,8,10a-Hexahydro-1,2,3,9-tetramethoxy-8-oxobenzo(a)cyclopenta(3,4)cyclobuta(1,2-c)cyclohepten-7-yl)acetamide
  • Acetamide, N-(5,6,7,7b,8,10a-hexahydro-1,2,3,9-tetramethoxy-8-oxobenzo[a]cyclopenta[3,4]cyclobuta[1,2-c]cyclohepten-7-yl)-, [7S-(7α,7bβ,10aβ)]-
  • Acetamide, N-[(7S,7bR,10aS)-5,6,7,7b,8,10a-hexahydro-1,2,3,9-tetramethoxy-8-oxobenzo[a]cyclopenta[3,4]cyclobuta[1,2-c]cyclohepten-7-yl]-
  • Benzo[a]cyclopenta[3,4]cyclobuta[1,2-c]cycloheptene, acetamide deriv.
  • Lumicolchicine
  • Lumicolchicine (9CI)
  • N-(1,2,3,9-tetramethoxy-8-oxo-5,6,7,7b,8,10a-hexahydrobenzo[a]cyclopenta[3,4]cyclobuta[1,2-c][7]annulen-7-yl)acetamide
  • N-[(7R,7bS,10aR)-1,2,3,9-tetramethoxy-8-oxo-5,6,7,7b,8,10a-hexahydrobenzo[a]cyclopenta[3,4]cyclobuta[1,2-c][7]annulen-7-yl]acetamide
  • N-[(7S,7bR,10aS)-1,2,3,9-tetramethoxy-8-oxo-5,6,7,7b,8,10a-hexahydrobenzo[a]cyclopenta[3,4]cyclobuta[1,2-c][7]annulen-7-yl]acetamide
  • See more synonyms
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Found 6 products.