CAS 69655-05-6

Didanosine

Description:

Didanosine, also known as ddI, is an antiretroviral medication primarily used in the treatment of HIV/AIDS. It belongs to the class of nucleoside reverse transcriptase inhibitors (NRTIs) and functions by inhibiting the reverse transcriptase enzyme, which is crucial for viral replication. Didanosine is a purine nucleoside analog, specifically an adenosine derivative, and is characterized by its ability to interfere with the viral life cycle. The substance is typically administered in its oral form, often as enteric-coated capsules or tablets, to enhance absorption and reduce gastrointestinal side effects. Didanosine is known for its potential side effects, including pancreatitis, peripheral neuropathy, and lactic acidosis, necessitating careful monitoring during treatment. It is important to note that didanosine is less commonly used today due to the availability of more effective and better-tolerated antiretroviral therapies. Its chemical structure includes a hydroxyl group and a modified sugar moiety, which contribute to its mechanism of action and pharmacological properties.

Formula: C₁₀H₁₂N₄O₃

InChI: InChI=1S/C10H12N4O3/c15-3-6-1-2-7(17-6)14-5-13-8-9(14)11-4-12-10(8)16/h4-7,15H,1-3H2,(H,11,12,16)/t6-,7+/m0/s1

InChI key: InChIKey=BXZVVICBKDXVGW-NKWVEPMBSA-N

SMILES: O=C1C2=C(N(C=N2)[C@@H]3O[C@H](CO)CC3)NC=N1

Synonyms:

• 2',3'-Dideoxy Inosine
• 2',3'-Dideoxyinosine
• 2',3'-Didesoxyinosine
• 2,3-Dideoxyinosine
• 9-[5-(hydroxymethyl)tetrahydrofuran-2-yl]-3,9-dihydro-6H-purin-6-one
• Bmy 40900
• DdI
• DdI (nucleoside)
• Didansine
• Dideoxyinosine
• Inosine, 2',3'-dideoxy-
• Inosine, 2′,3′-dideoxy-
• Nsc 612049
• Videx
• Videx EC

2’,3’-Dideoxyinosine-13C2,15N

Controlled Product

CAS: 69655-05-6

Applications Labelled Didanosine, which is used as an antiviral.
References Dahlberg, J.E., et al.: Proc. Nat. Acad. Sci. U.S.A., 83, 1911 (1986)

Formula: C₂C₈H₁₂₁₅NN₃O₃

Color and Shape: Neat

Molecular weight: 239.206

Ref: TR-D440952

Didanosine

CAS: 69655-05-6

Formula: C₁₀H₁₂N₄O₃

Molecular weight: 236.23

Ref: ST-EA-CP-D114000