CAS 69655-05-6

Didanosine

Description:

Didanosine, also known as ddI, is an antiretroviral medication primarily used in the treatment of HIV/AIDS. It belongs to the class of nucleoside reverse transcriptase inhibitors (NRTIs) and functions by inhibiting the reverse transcriptase enzyme, which is crucial for viral replication. Didanosine is a purine nucleoside analog, specifically an adenosine derivative, and is characterized by its ability to interfere with the viral life cycle. The substance is typically administered in its oral form, often as enteric-coated capsules or tablets, to enhance absorption and reduce gastrointestinal side effects. Didanosine is known for its potential side effects, including pancreatitis, peripheral neuropathy, and lactic acidosis, necessitating careful monitoring during treatment. It is important to note that didanosine is less commonly used today due to the availability of more effective and better-tolerated antiretroviral therapies. Its chemical structure includes a hydroxyl group and a modified sugar moiety, which contribute to its mechanism of action and pharmacological properties.

Formula: C₁₀H₁₂N₄O₃

InChI: InChI=1S/C10H12N4O3/c15-3-6-1-2-7(17-6)14-5-13-8-9(14)11-4-12-10(8)16/h4-7,15H,1-3H2,(H,11,12,16)/t6-,7+/m0/s1

InChI key: InChIKey=BXZVVICBKDXVGW-NKWVEPMBSA-N

SMILES: O=C1C2=C(N(C=N2)[C@@H]3O[C@H](CO)CC3)NC=N1

Synonyms:

• 2',3'-Dideoxy Inosine
• 2',3'-Dideoxyinosine
• 2',3'-Didesoxyinosine
• 2,3-Dideoxyinosine
• 9-[5-(hydroxymethyl)tetrahydrofuran-2-yl]-3,9-dihydro-6H-purin-6-one
• Bmy 40900
• DdI
• DdI (nucleoside)
• Didansine
• Dideoxyinosine
• Inosine, 2',3'-dideoxy-
• Inosine, 2′,3′-dideoxy-
• Nsc 612049
• Videx
• Videx EC

2',3'-Dideoxyinosine, 98%

CAS: 69655-05-6

2?,3?-Dideoxyinosine is a potent anti-retroviral agent. It is most effective in combination therapy for the treatment of HIV and related lymphoma. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refe

Formula: C₁₀H₁₂N₄O₃

Purity: 98%

Molecular weight: 236.23

Ref: 02-J64833

DIDANOSINE CRS

CAS: 69655-05-6

DIDANOSINE CRS

Formula: C₁₀H₁₂N₄O₃

Color and Shape: Powder

Molecular weight: 236.2273

Ref: 41-Y0000439

DIDANOSINE FOR SYSTEM SUITABILITY CRS

CAS: 69655-05-6

DIDANOSINE FOR SYSTEM SUITABILITY CRS

Formula: C₁₀H₁₂N₄O₃

Color and Shape: Powder

Molecular weight: 236.2273

Ref: 41-Y0000440

Didanosine

CAS: 69655-05-6

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₁₀H₁₂N₄O₃

Color and Shape: White Powder

Molecular weight: 236.23 g/mol

Ref: 45-1191204

Didanosine System Suitability Mixture

CAS: 69655-05-6

Diagnostic or lab reagents on a backing, prepared diagnostic or lab reagents whether or not on a backing, whether or not in the form of kits, nesoi

Color and Shape: White Powder

Ref: 45-1191215

9-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one

CAS: 69655-05-6

Formula: C₁₀H₁₂N₄O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 236.2273

Ref: IN-DA0036OD

2',3'-Dideoxyinosine

CAS: 69655-05-6

9-((2R,5S)-5-(Hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol

Formula: C₁₀H₁₂N₄O₃

Purity: 98%

Molecular weight: 236.23

Ref: IN-DG12003

Didanosine

CAS: 69655-05-6

Didanosine

Formula: C₁₀H₁₂N₄O₃

Purity: ≥98%

Molecular weight: 236.23

Ref: 54-BUP13624

Didanosine

CAS: 69655-05-6

Formula: C₁₀H₁₂N₄O₃

Purity: 98.0 - 102.0 % (dried basis)

Color and Shape: White to almost white crystalline powder

Molecular weight: 236.23

Ref: 7W-GP9351

Didanosine-d2

CAS: 69655-05-6

Formula: C₁₀H₁₀D₂N₄O₃

Color and Shape: Off-White Solid

Molecular weight: 238.24

Ref: 4Z-D-221

Didanosine

CAS: 69655-05-6

Formula: C₁₀H₁₂N₄O₃

Color and Shape: White To Off-White Solid

Molecular weight: 236.23

Ref: 4Z-D-225

2',3'-Dideoxyinosine

CAS: 69655-05-6

2',3'-Dideoxyinosine

Formula: C₁₀H₁₂N₄O₃

Color and Shape: Solid-Powder

Molecular weight: 236.22728

Ref: 54-BID2043

Didanosine

CAS: 69655-05-6

Formula: C₁₀H₁₂N₄O₃

Color and Shape: Neat

Molecular weight: 236.23

Ref: 86-MM1047.00

2',3'-Dideoxyinosine

CAS: 69655-05-6

Formula: C₁₀H₁₂N₄O₃

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 236.23

Ref: 3B-D3066

Didanosine

CAS: 69655-05-6

Didanosine (ddI) is a nucleoside reverse transcriptase inhibitor analog of adenosine (IC50: 0.49 μM).

Formula: C₁₀H₁₂N₄O₃

Purity: 99.64%

Color and Shape: Solid

Molecular weight: 236.23

Ref: TM-T2578

2’,3’-Dideoxyinosine

Controlled Product

CAS: 69655-05-6

Applications 2’,3’-Dideoxyinosine is a purine analog (1) which used as an antiviral agent. Classed as an anti-retroviral drug used in the treatment of HIV in ART therapy, it also may increase acetaminophen related hepatotoxicity by enhancing mitochrondrial dysfunction (2).
References 1. Esplugues, J. et al.: AIDS. 2016 Jun 1;30(9):1341-51.2. Blas-Garcia, A. et al.: J. Antimicrob. Chemother. 2016 Apr;71(4):916-26

Formula: C₁₀H₁₂N₄O₃

Color and Shape: Neat

Molecular weight: 236.23

Ref: TR-D440950

2',3'-Dideoxyinosine

CAS: 69655-05-6

2',3'-Dideoxyinosine is a purine analog that can suppress human immunodeficiency virus (HIV) replication after intracellular metabolic conversion

Formula: C₁₀H₁₂N₄O₃

Purity: Min. 95 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 236.23 g/mol

Ref: 3D-ND02929

2,3-Dideoxyinosine (ddI, ddIno) extrapure, 98%

CAS: 69655-05-6

Formula: C₁₀H₁₂N₄O₃

Purity: min. 98 %

Color and Shape: White, Crystalline powder

Molecular weight: 236.23

Ref: SR-73273

Didanosine

CAS: 69655-05-6

Formula: C₁₀H₁₂N₄O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 236.231

Ref: 10-F326235

2’,3’-Dideoxyinosine-13C2,15N

Controlled Product

CAS: 69655-05-6

Applications Labelled Didanosine, which is used as an antiviral.
References Dahlberg, J.E., et al.: Proc. Nat. Acad. Sci. U.S.A., 83, 1911 (1986)

Formula: C₂C₈H₁₂₁₅NN₃O₃

Color and Shape: Neat

Molecular weight: 239.206

Ref: TR-D440952