CAS 6969-71-7

1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one

Description:

1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one, with the CAS number 6969-71-7, is a heterocyclic compound featuring a fused triazole and pyridine ring system. This compound is characterized by its unique structural framework, which includes a triazole ring that contributes to its potential biological activity. It typically exhibits properties such as moderate solubility in polar solvents and may possess acidic or basic characteristics depending on the functional groups present. The presence of the triazole moiety often imparts interesting pharmacological properties, making it a subject of interest in medicinal chemistry for its potential applications in drug development. Additionally, this compound may participate in various chemical reactions, including nucleophilic substitutions and cycloadditions, due to the reactivity of its nitrogen atoms. Its derivatives are often explored for their roles in various therapeutic areas, including anti-inflammatory and antimicrobial activities. Overall, 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one represents a versatile scaffold in organic synthesis and medicinal chemistry.

Formula: C₆H₅N₃O

InChI: InChI=1/C6H5N3O/c10-6-8-7-5-3-1-2-4-9(5)6/h1-4H,(H,8,10)

InChI key: InChIKey=LJRXNXBFJXXRNQ-UHFFFAOYSA-N

SMILES: O=C1N2C(C=CC=C2)=NN1

Synonyms:

• 1,2,4-Triazolo-[4,3-a]-Pyridine-3(2H)-One
• 1,2,4-triazolo-4,3-pyridin-3(2H)-one
• 1,2,4-trizolo(4,3a)pyridin-3(2H)-one
• 2H,3H-[1,2,4]Triazolo[4,3-a]pyridin-3-one
• 2H-[1,2,4]Triazolo[4,3-a]pyridin-3-one
• 3-Hydroxytriazolo[4,3-a]pyridine
• NSC 68462
• [1,2,4]Triazolo[4,3-a]pyridin-3-ol
• s-Triazolo[4,3-a]pyridin-3-ol
• 1,2,4-Triazolo(4,3-a)-pyridin-3(2H)-one
• [1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
• 1,2,4-triazolo[4,3-a]pyridin-3(2H)one
• 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one
• 1,2,4-Triazole-(4,3-alpha)pyri
• 1,2,4-Triazolopyridin-3-one
• 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one, 98+%
• 1,2,4-Triazole-(4,3-a) Pyridine-3 (2H)-One
• 3-HYDROXY-1,2,4-TRIAZOLO[4,3-A]PYRIDINE
• 1,2,4-TRIAZOLE(4,3)PYRIDIN-3-(2H)-ONE
• 1,2,4-TRIAZOL-(4,3-A)-PYRIDINE 3 (2H)-ONE

1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one

CAS: 6969-71-7

Formula: C₆H₅N₃O

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Green to Brown powder to crystal

Molecular weight: 135.13

Ref: 3B-T1667

1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one, 98+%

CAS: 6969-71-7

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₆H₅N₃O

Purity: 98+%

Color and Shape: White to cream, Crystals or powder or crystalline powder

Molecular weight: 135.13

Ref: 02-L18705

1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one

CAS: 6969-71-7

Formula: C₆H₅N₃O

Purity: 98%

Color and Shape: Solid

Molecular weight: 135.1234

Ref: IN-DA003AZP

Trazodone EP Impurity K (Triazolopyridinone)

CAS: 6969-71-7

Formula: C₆H₅N₃O

Color and Shape: Off-White Solid

Molecular weight: 135.13

Ref: 4Z-T-3318

1,2,4-Triazolo[4,3-a]pyridine-3(2H)-one

Controlled Product

CAS: 6969-71-7

Formula: C₆H₅N₃O

Color and Shape: Neat

Molecular weight: 135.12

Ref: 86-MM0421.11

[1,2,4]Triazolo[4,3-a]pyridin-3-ol

CAS: 6969-71-7

[1,2,4]Triazolo[4,3-a]pyridin-3-ol

Purity: 98%

Molecular weight: 135.12g/mol

Ref: 54-OR943678

1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one

Controlled Product

CAS: 6969-71-7

Applications 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one was used to prepare a congener of Trazodone (T718500) which was found to be a potent and selective inhibitor of synaptosomal uptake of 5-hydroxytryptamine.
References Alhaider, A.A.: J. Pharmac. Sci., 81, 99 (1992);

Formula: C₆H₅N₃O

Color and Shape: Neat

Molecular weight: 135.12

Ref: TR-T767505

Trazodone EP Impurity K

CAS: 6969-71-7

Formula: C₆H₅N₃O

Molecular weight: 135.13

Ref: ST-EA-CP-T29011

[1,2,4]Triazolo[4,3-a]pyridin-3(2H)-one

CAS: 6969-71-7

Formula: C₆H₅N₃O

Purity: 98%

Color and Shape: Solid

Molecular weight: 135.126

Ref: 10-F069239

1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one

CAS: 6969-71-7

1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one is a potent inhibitor of the enzyme c-glycosylase. This compound has been used in pharmaceutical preparations and as a feedstock in organic syntheses. It is used to produce the anti-inflammatory drug piroxicam, which inhibits the action of cyclooxygenase and blocks the synthesis of prostaglandins. 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one also has been shown to inhibit crystallization of the bovine liver enzyme phosphatidylcholine:cholesterol acyltransferase (PCAT). The inhibition was found to be competitive with respect to PCAT substrate and was not due to inhibition of PCAT by 1,2,4-triazolo[4,3-a]pyridin-3(

Formula: C₆H₅N₃O

Purity: Min. 95%

Molecular weight: 135.13 g/mol

Ref: 3D-GAA96971