CAS 6974-78-3

8-Bromo-9H-purin-6-amine

Description:

8-Bromo-9H-purin-6-amine, with the CAS number 6974-78-3, is a purine derivative characterized by the presence of a bromine atom at the 8-position and an amino group at the 6-position of the purine ring. This compound is typically a white to off-white solid and is soluble in polar solvents such as water and dimethyl sulfoxide (DMSO). It exhibits properties typical of purines, including the ability to participate in hydrogen bonding due to the presence of the amino group, which can influence its reactivity and interactions in biological systems. The bromine substituent can also affect the compound's electronic properties, potentially enhancing its reactivity in nucleophilic substitution reactions. 8-Bromo-9H-purin-6-amine is of interest in medicinal chemistry and biochemistry, particularly in the study of nucleic acids and as a potential building block for the synthesis of various bioactive molecules. Its structural features may also contribute to its role in research related to cancer and antiviral therapies.

Formula: C₅H₄BrN₅

InChI: InChI=1S/C5H4BrN5/c6-5-10-2-3(7)8-1-9-4(2)11-5/h1H,(H3,7,8,9,10,11)

InChI key: InChIKey=FVXHPCVBOXMRJP-UHFFFAOYSA-N

SMILES: NC1=C2C(N=C(Br)N2)=NC=N1

Synonyms:

• 8-Bromoadenine
• 8-Bromo-9H-purin-6-amine
• Adenine, 8-bromo-
• 1H-Purin-6-amine, 8-bromo-
• 9H-Purin-6-amine, 8-bromo-

8-Bromoadenine

CAS: 6974-78-3

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₅H₄BrN₅

Color and Shape: White, Powder

Molecular weight: 214.03

Ref: 02-J65582

1H-Purin-6-amine, 8-bromo-

CAS: 6974-78-3

Formula: C₅H₄BrN₅

Purity: 95%

Color and Shape: Solid

Molecular weight: 214.0228

Ref: IN-DA00IBZ7

8-Bromo-9H-purin-6-amine

CAS: 6974-78-3

8-Bromo-9H-purin-6-amine

Purity: 97%

Molecular weight: 214.02g/mol

Ref: 54-OR94370

8-Bromoadenine

CAS: 6974-78-3

Formula: C₅H₄BrN₅

Purity: ≥ 98.0%

Color and Shape: White to pale brown powder

Molecular weight: 214.03

Ref: 7W-GK5999

8-Bromoadenine

CAS: 6974-78-3

8-Bromoadenine is a nucleophile that reacts with electrophiles to form adducts. 8-Bromoadenine has been shown to induce DNA strand breaks and oxidative damage in vitro, which may be due to its ability to react with DNA bases and form intramolecular hydrogen bonds. 8-Bromoadenine has also been shown to cause inflammatory bowel disease in mice by increasing the production of proinflammatory cytokines. 8-Bromoadenine induces Toll-like receptor 4 (TLR4) signaling, which leads to enhancement of radiation response. This drug can also be used as the monosodium salt for treating cancer, although it only has a limited number of sequences that can be synthesized.

Formula: C₅H₄BrN₅

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 214.02 g/mol

Ref: 3D-FB08273

8-Bromo-7H-purin-6-amine

CAS: 6974-78-3

Formula: C₅H₄BrN₅

Purity: 97%

Color and Shape: Liquid, No data available.

Molecular weight: 214.026

Ref: 10-F222934

8-Bromoadenine

Controlled Product

CAS: 6974-78-3

Formula: C₅H₄BrN₅

Color and Shape: Neat

Molecular weight: 214.02

Ref: TR-B679370

8-Bromoadenine-13C2,15N2

Controlled Product

CAS: 6974-78-3

Formula: C₂C₃H₄Br₁₅N₂N₃

Color and Shape: Neat

Molecular weight: 217.995

Ref: TR-B679372