CAS 6990-06-3

Fusidic acid

Description:

Fusidic acid is a steroidal antibiotic primarily derived from the fungus Fusidium coccineum. It is characterized by its ability to inhibit bacterial protein synthesis, making it effective against a range of Gram-positive bacteria, including Staphylococcus aureus. Fusidic acid is often used in topical formulations for treating skin infections, particularly those caused by resistant strains. The compound is known for its low solubility in water, which influences its formulation and delivery methods. It has a relatively low toxicity profile, but its use can lead to resistance if not administered appropriately. Fusidic acid is typically available in various forms, including creams, ointments, and eye drops, and is sometimes combined with other antibiotics to enhance its efficacy. Its mechanism of action involves binding to the elongation factor G (EF-G) in bacteria, thereby preventing the translocation step during protein synthesis. Overall, fusidic acid is a valuable agent in the treatment of localized infections, particularly in dermatological applications.

Formula: C₃₁H₄₈O₆

InChI: InChI=1/C31H48O6/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36)/b26-20+/t18-,21-,22-,23+,24+,25-,27?,29-,30-,31-/m0/s1

InChI key: InChIKey=IECPWNUMDGFDKC-MZJAQBGESA-N

SMILES: C[C@@]12[C@]3(C)[C@](/C(=C(\CCC=C(C)C)/C(O)=O)/[C@@H](OC(C)=O)C3)(C[C@@H](O)[C@]1([C@]4(C)[C@@](CC2)([C@H](C)[C@H](O)CC4)[H])[H])[H]

Synonyms:

• (2E)-2-[(3alpha,4alpha,5alpha,8alpha,9xi,11alpha,13alpha,14beta,16beta,17E)-16-(acetyloxy)-3,11-dihydroxy-4,8,10,14-tetramethylgonan-17-ylidene]-6-methylhept-5-enoic acid
• (2Z)-2-[(3alpha,4alpha,5alpha,8alpha,9beta,11alpha,13alpha,14beta,16beta,17Z)-16-(acetyloxy)-3,11-dihydroxy-4,8,10,14-tetramethylgonan-17-ylidene]-6-methylhept-5-enoic acid
• (3α,4α,8α,9β,11α,13α,14β,16β,17Z)-16-(Acetyloxy)-3,11-dihydroxy-29-nordammara-17(20),24-dien-21-oic acid
• 16-(Acetyloxy)-3,11-dihydroxy-29-nordammara-17(20),24-dien-21-oic acid
• 29-Nor-8α,9β,13α,14β-dammara-17(20),24-dien-21-oic acid, 3α,11α,16β-trihydroxy-, 16-acetate, (Z)-
• 29-Nordammara-17(20),24-dien-21-oic acid, 16-(acetyloxy)-3,11-dihydroxy-, (3α,4α,8α,9β,11α,13α,14β,16β,17Z)-
• Acide Fusidique
• Acido Fusidico
• Flucidin
• Foban
• Fucithalmic
• Fugen
• Fusidate Acid
• Fusidic Acid
• Fusidine
• Fusidinic acid
• Fusidinsaure
• Nsc 56192
• Optifucin
• Phudicin
• Ramycin
• Sq 16603
• Usidin
• (3alpha,4alpha,8alpha,9beta,11alpha,13alpha,14beta,16beta,17Z)-16-(acetyloxy)-3,11-dihydroxy-29-Nordammara-17(20),24-dien-21-oic acid
• 4-alpha,8-alpha,9-beta,11-alpha,13-alpha,14-beta,16-beta,17z)-ph
• FUSIDIC ACID IP
• (4S,8α,9β,13α,14β,17Z)-16β-Acetoxy-3α,11α-dihydroxy-29-nor-5α-dammara-17(20),24-dien-21-oic acid
• (8α,9β,13α,14β,Z)-16β-Acetyloxy-3α,11α-dihydroxy-29-nordammara-17(20),24-dien-21-oic acid
• sq16603
• (3ALPHA,4ALPHA,8ALPHA,9BETA,11ALPHA,13ALPHA,14BETA,16BETA,17Z)-16-(ACETYLOXY)-3,11-DIHYDROXY-29-NORDAMMARA-17(20),24-DIEN-21-OIC ACID
• (3a,4a,8a,9,11a,13a,147,167,17Z)-16-(Acetyloxy)-3,11-dihydroxy-29-nordammara-17(20),24-dien-21-oic Acid
• 24-dien-21-oicacid,16-(acetyloxy)-3,11-dihydroxy-29-nordammara-17(20(3-al
• 29-Nordammara-17(20),24-dien-21-oic acid, 16-(acetyloxy)-3,11-dihydroxy-, (3.alpha.,4.alpha.,8.alpha.,9.beta.,11.alpha.,13.alpha.,14.beta.,16.beta.,17Z)-

Fusidic acid; Fucidin; Ramycin; NSC 56192; NSC-5619-2; SQ 16603; ZN-6; Fusidinic acid

CAS: 6990-06-3

Formula: C₃₁H₄₈O₆

Purity: 85.66%

Color and Shape: Brownish oily solid

Molecular weight: 516.0

Ref: 8R-AD0023

FUSIDIC ACID CRS

CAS: 6990-06-3

FUSIDIC ACID CRS

Formula: C₃₁H₄₈O₆

Color and Shape: Added Modified

Molecular weight: 516.7092

Ref: 41-Y0001411

FUSIDIC ACID FOR PEAK IDENTIFICATION CRS

CAS: 6990-06-3

FUSIDIC ACID FOR PEAK IDENTIFICATION CRS

Formula: C₃₁H₄₈O₆

Color and Shape: Crystalline Powder. White. Powder.

Molecular weight: 516.7092

Ref: 41-Y0001394

(3α,4α,8α,9β,11α,13α,14β,16β,17Z)-16-(Acetyloxy)-3,11-dihydroxy-29-nordammara-17(20),24-dien-21-oic acid

CAS: 6990-06-3

Formula: C₃₁H₄₈O₆

Purity: 97%

Color and Shape: Solid

Molecular weight: 516.7092

Ref: IN-DA003ACO

Fusidic acid

CAS: 6990-06-3

Fusidic acid (Fusidine) is an antibiotic isolated from the fermentation broth of Fusidium coccineum.

Formula: C₃₁H₄₈O₆

Purity: 98.68% - 99.53%

Color and Shape: Solid

Molecular weight: 516.71

Ref: TM-T1160

Fusidic acid

CAS: 6990-06-3

Fusidic acid

Purity: ≥98%

Molecular weight: 516.71g/mol

Ref: 54-BUP16640

Fusidic acid

CAS: 6990-06-3

Formula: C₃₁H₄₈O₆·xH₂O

Purity: 98.0 - 101.0 % (dried basis)

Color and Shape: White or almost white crystalline powder

Molecular weight: 516.71 (anhydrous)

Ref: 7W-GA1848

Fusidic Acid

CAS: 6990-06-3

Formula: C₃₁H₄₈O₆

Color and Shape: White To Off-White Solid

Molecular weight: 516.72

Ref: 4Z-F-281

Fusidic Acid

CAS: 6990-06-3

Formula: C₃₁H₄₈O₆

Purity: >97.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 516.72

Ref: 3B-F1007

Fusidic acid

Controlled Product

CAS: 6990-06-3

Formula: C₃₁H₄₈O₆

Color and Shape: Neat

Molecular weight: 516.71

Ref: 04-C13989500

Fusidic acid, free acid

CAS: 6990-06-3

Fusidic acid, free acid

Formula: C₃₁H₄₈O₆

Purity: 97%

Color and Shape: white solid

Molecular weight: 516.71g/mol

Ref: 54-BIF6400

Fusidic Acid-d6

Controlled Product

CAS: 6990-06-3

Applications Fusidic acid is a bacteriostatic antibiotic. Fusidic Acid suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA.
References Collignon, P., et al.: Int. J. Antimicrob. Agents, 12, S45 (1999), Di Marco, R., et al.: J. Autoimmun., 13, 187 (1999), Price, C.T., et al.: J. Antimicrob., Chemother., 44, 57 (1999),

Formula: C₃₁H₄₂D₆O₆

Color and Shape: Neat

Molecular weight: 522.71

Ref: TR-F865502

Fusidic Acid

CAS: 6990-06-3

Stability Hygroscopic
Applications Fusidic acid is a bacteriostatic antibiotic. Fusidic Acid suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA. Dyes and metabolites.
References Collignon, P., et al.: Int. J. Antimicrob. Agents, 12, S45 (1999), Di Marco, R., et al.: J. Autoimmun., 13, 187 (1999), Price, C.T., et al.: J. Antimicrob., Chemother., 44, 57 (1999),

Formula: C₃₁H₄₈O₆

Color and Shape: White

Molecular weight: 516.71

Ref: TR-F865500

FUSIDIC ACID

CAS: 6990-06-3

Purity: 95%

Color and Shape: Solid

Molecular weight: 516.718994140625

Ref: 10-F794556

Fusidic acid

CAS: 6990-06-3

Inhibitor of protein synthesis; steroid antibiotic

Formula: C₃₁H₄₈O₆

Purity: Min. 95 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 516.71 g/mol

Ref: 3D-AF23629