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CAS 6990-06-3

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Fusidic acid

Description:
Fusidic acid is a steroidal antibiotic primarily derived from the fungus Fusidium coccineum. It is characterized by its ability to inhibit bacterial protein synthesis, making it effective against a range of Gram-positive bacteria, including Staphylococcus aureus. Fusidic acid is often used in topical formulations for treating skin infections, particularly those caused by resistant strains. The compound is known for its low solubility in water, which influences its formulation and delivery methods. It has a relatively low toxicity profile, but its use can lead to resistance if not administered appropriately. Fusidic acid is typically available in various forms, including creams, ointments, and eye drops, and is sometimes combined with other antibiotics to enhance its efficacy. Its mechanism of action involves binding to the elongation factor G (EF-G) in bacteria, thereby preventing the translocation step during protein synthesis. Overall, fusidic acid is a valuable agent in the treatment of localized infections, particularly in dermatological applications.
Formula:C31H48O6
InChI:InChI=1/C31H48O6/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36)/b26-20+/t18-,21-,22-,23+,24+,25-,27?,29-,30-,31-/m0/s1
InChI key:InChIKey=IECPWNUMDGFDKC-MZJAQBGESA-N
SMILES:C[C@@]12[C@]3(C)[C@](/C(=C(\CCC=C(C)C)/C(O)=O)/[C@@H](OC(C)=O)C3)(C[C@@H](O)[C@]1([C@]4(C)[C@@](CC2)([C@H](C)[C@H](O)CC4)[H])[H])[H]
Synonyms:
  • (2E)-2-[(3alpha,4alpha,5alpha,8alpha,9xi,11alpha,13alpha,14beta,16beta,17E)-16-(acetyloxy)-3,11-dihydroxy-4,8,10,14-tetramethylgonan-17-ylidene]-6-methylhept-5-enoic acid
  • (2Z)-2-[(3alpha,4alpha,5alpha,8alpha,9beta,11alpha,13alpha,14beta,16beta,17Z)-16-(acetyloxy)-3,11-dihydroxy-4,8,10,14-tetramethylgonan-17-ylidene]-6-methylhept-5-enoic acid
  • (3α,4α,8α,9β,11α,13α,14β,16β,17Z)-16-(Acetyloxy)-3,11-dihydroxy-29-nordammara-17(20),24-dien-21-oic acid
  • 16-(Acetyloxy)-3,11-dihydroxy-29-nordammara-17(20),24-dien-21-oic acid
  • 29-Nor-8α,9β,13α,14β-dammara-17(20),24-dien-21-oic acid, 3α,11α,16β-trihydroxy-, 16-acetate, (Z)-
  • 29-Nordammara-17(20),24-dien-21-oic acid, 16-(acetyloxy)-3,11-dihydroxy-, (3α,4α,8α,9β,11α,13α,14β,16β,17Z)-
  • Acide Fusidique
  • Acido Fusidico
  • Flucidin
  • Foban
  • See more synonyms
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