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CAS 70-00-8

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Trifluridine

Description:
Trifluridine is a synthetic nucleoside analog primarily used as an antiviral medication, particularly in the treatment of herpes simplex virus infections. Its chemical structure is characterized by the presence of a fluorinated pyrimidine base, which enhances its antiviral activity by interfering with viral DNA synthesis. Trifluridine is known for its ability to inhibit the replication of both DNA and RNA viruses, making it effective against a range of viral pathogens. The substance is typically administered topically in the form of an ophthalmic solution for the treatment of viral keratitis. In terms of physical properties, trifluridine is a white to off-white crystalline powder that is soluble in water and exhibits stability under normal storage conditions. Its mechanism of action involves incorporation into viral DNA, leading to chain termination and ultimately inhibiting viral replication. While generally well-tolerated, potential side effects may include local irritation or allergic reactions. As with any medication, it is important to use trifluridine under the guidance of a healthcare professional.
Formula:C10H11F3N2O5
InChI:InChI=1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h2,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6+,7+/m0/s1
InChI key:InChIKey=VSQQQLOSPVPRAZ-RRKCRQDMSA-N
SMILES:O=C1N([C@@H]2O[C@H](CO)[C@@H](O)C2)C=C(C(F)(F)F)C(=O)N1
Synonyms:
  • 2-Deoxy-5-(trifluoromethyl)uridine
  • 5-(Trifluoromethyl)-2-deoxyuridine
  • 5-(Trifluoromethyl)deoxyuridine
  • 5-Trifluoromethyl-2'-deoxy-β-uridine
  • 5-Trifluorothymidine
  • Nsc 529182
  • Nsc 75520
  • Thymidine, α,α,α-trifluoro-
  • Trifluorothymidine
  • Trifluridin
  • See more synonyms
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