CAS 70-51-9

Deferoxamine

Description:

Deferoxamine is a chelating agent primarily used in the treatment of iron overload conditions, such as those resulting from repeated blood transfusions in patients with conditions like thalassemia or sickle cell disease. It is a hexadentate ligand, meaning it can form multiple bonds with a single metal ion, specifically binding to ferric ions (Fe³⁺) to facilitate their excretion from the body. Deferoxamine is typically administered via subcutaneous or intravenous routes, as it is poorly absorbed from the gastrointestinal tract. The compound is characterized by its ability to form stable complexes with iron, which helps to reduce iron toxicity and prevent organ damage. In addition to its therapeutic uses, deferoxamine has been studied for its potential antioxidant properties and its role in various research applications. Its chemical structure includes a hydroxamic acid functional group, which is crucial for its chelation properties. Overall, deferoxamine plays a vital role in managing iron overload and improving patient outcomes in specific hematological disorders.

Formula: C₂₅H₄₈N₆O₈

InChI: InChI=1/C25H48N6O8/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34)

InChI key: InChIKey=UBQYURCVBFRUQT-UHFFFAOYSA-N

SMILES: C(CCC(NCCCCCN(C(C)=O)O)=O)(N(CCCCCNC(CCC(N(CCCCCN)O)=O)=O)O)=O

Synonyms:

• 3,9,14,20,25-Pentaazatriacontane-2,10,13,21,24-pentone, 30-amino-3,14,25-trihydroxy-
• 30-Amino-3,14,25-trihydroxy-3,9,14,20,25 pentaazatriacontane-2,10,13,21,24-pentaone
• Butanediamide, N'-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N-(5-aminopentyl)-N-hydroxy-
• Butanediamide, N⁴-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N¹-(5-aminopentyl)-N¹-hydroxy-
• Deferoxamin
• Deferoxamina
• Deferoxamine B
• Deferriferrioxamine B
• Deferrioxamine
• Deferrioxamine B
• Desferan
• Desferex
• Desferin
• Desferioxamine B
• Desferoxime
• Desferrin
• Desferrioxamine
• Desferrioxamine B
• Dfo-B
• N'-{5-[acetyl(hydroxy)amino]pentyl}-N-[5-({4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanoyl}amino)pentyl]-N-hydroxybutanediamide
• N-[5-[3-[(5-Aminopentyl)hydroxycarbamoyl]propionamido]pentyl]-3-[[5-(N-hydroxyacetamido)pentyl]carbamoyl]propionohydroxamic acid
• N⁴-[5-[[4-[[5-(Acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N¹-(5-aminopentyl)-N¹-hydroxybutanediamide
• Nsc 527604
• N′-[5-[Acetyl(hydroxy)amino]pentyl]-N-7-[5-([4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanoyl]amino)pentyl]-N-hydroxysuccinamide
• Propionohydroxamic acid, N-[5-[3-[(5-aminopentyl)hydroxycarbamoyl]propionamido]pentyl]-3-[[5-(N-hydroxyacetamido)pentyl]carbamoyl]-
• N4-[5-[[4-[[5-(Acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N1-(5-aminopentyl)-N1-hydroxybutanediamide
• Butanediamide, N4-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N1-(5-aminopentyl)-N1-hydroxy-
• n-[5-[3-[(5-aminopentyl)hydroxycarbamoyl]propionamido]pentyl]-3-[[5-(n-hydroxy
• ba-33112
• deferoxaminum
• n’-[5-[[4-[[5-(acetylhydroxamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pen
• N1-(5-aminopentyl)-N1-hydroxy-N4-(5-(N-hydroxy-4-((5-(N-hydroxyacetamido)pentyl)amino)-4-oxobutanamido)pentyl)succinamide
• butanediamide,n’-(5-((4-((5-(acetylhydroxyamino)pentyl)amino)-1,4-dioxobutyl)h
• deferoxamideb
• entaone
• 1-amino-6,17-dihydroxy-7,10,18,21-tetraoxo-27-(n-acetylhydroxylamino)-6,11,17,
• acetamido)pentyl]carbamoyl]propionohydroxamicacid
• N'-[5-[acetyl(hydroxy)amino]pentyl]-N-[5-[[4-[5-aminopentyl(hydroxy)amino]-4-keto-butanoyl]amino]pentyl]-N-hydroxy-succinamide
• n-benzoyl-ferrioxamine
• Deferoxamine USP/EP/BP
• taone
• 3,9,14,20,25-pentaazatriacontane-2,10,13,21,24-pentone,30-amino-3,14,25-trihyd
• N1-(5-Aminopentyl)-N1-hydroxy-N4-(5-(N-hydroxy-4-((5-(N-hydroxyacetamido)-pentyl)amino)-4-oxobuta
• deferoxamine
• deferoxamineb
• desferrioxamineb
• 3,9,14,20,25-pentaazatriacontane-2,10,13,21,24-pentone,30-amino-3,14,25-trih
• ba-29837
• tyl]-n-(5-aminopentyl)-n-hydroxybutanediamide
• deferrioxamineb
• desferriferrioxaminb
• 30-amino-3,14,25-trihydroxy-3,9,14,20,25-pentaazatriacontane-2,10,13,21,24-p
• 30-amino-3,14,25-trihydroxy-3,9,14,20,25-pentaazatriacontane-2,10,13,21,24-pen
• ba33112
• N'-{5-[ACETYL(HYDROXY)AMINO]PENTYL}-N-[5-({4-[(5-AMINOPENTYL)(HYDROXY)AMINO]-4-OXOBUTANOYL}AMINO)PENTYL]-N-HYDROXYSUCCINAMIDE
• N'-[5-[[4-[[5-(Acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N-(5-aminopentyl)-N-hydroxysuccinamide
• N-[5-[[4-[5-azanylpentyl(hydroxy)amino]-4-oxo-butanoyl]amino]pentyl]-N'-[5-[ethanoyl(hydroxy)amino]pentyl]-N-hydroxy-butanediamide
• 22-tetraazaheptaeicosane
• n-benzoylferrioxamineb
• DESFEROXAMINE
• DESFERROXAMINE
• desferral
• ydroxyamino)pentyl)-n-(5-aminopentyl)-n-hydroxy-
• dfoa

Deferoxamine Mesylate

CAS: 138-14-7, 70-51-9

Formula: C₂₅H₄₈N₆O₈·CH₄O₃S

Purity: >97.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 656.79

Ref: 3B-D4245

Deferoxamine

CAS: 70-51-9

Deferoxamine (Desferrioxamine B) is an iron chelator. Deferoxamine has antioxidant, anti-proliferative and anti-tumor activities. High-Quality, Low-Cost!

Formula: C₂₅H₄₈N₆O₈

Purity: 99.66% - 99.97%

Color and Shape: Solid

Molecular weight: 560.68

Ref: TM-T124358

N1-(5-Aminopentyl)-N1-hydroxy-N4-(5-(N-hydroxy-4-((5-(N-hydroxyacetamido)pentyl)amino)-4-oxobutanamido)pentyl)succinamide

CAS: 70-51-9

Formula: C₂₅H₄₈N₆O₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 560.6840

Ref: IN-DA005IGL

Deferoxamine

CAS: 70-51-9

Deferoxamine

Purity: ≥98%

Molecular weight: 560.68g/mol

Ref: 54-BUP04137

Deferoxamine

CAS: 70-51-9

Deferoxamine is a polymerase chain inhibitor that binds to the folate receptor, a protein on the surface of cells. It is used as an antidote to poisoning by iron, arsenic, and other metals. Deferoxamine also has antioxidant properties and can be used in the treatment of iron overload diseases such as hemochromatosis. Deferoxamine-iron complexes are excreted in the urine, which may be useful for monitoring iron homeostasis. This drug is not active against squamous cell carcinomas or wild-type strains of bacteria that do not have a functional folate receptor.

Formula: C₂₅H₄₈N₆O₈

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 560.68 g/mol

Ref: 3D-FD46531