CAS 701232-20-4

Cyclohexaneacetic acid,4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]-, trans-

Description:

Cyclohexaneacetic acid, 4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]-, trans- is a complex organic compound characterized by its unique structural features, which include a cyclohexane ring and a pyrimido[4,5-b][1,4]oxazine moiety. This compound likely exhibits properties typical of both carboxylic acids and aromatic amines, including potential acidity due to the carboxylic acid group and basicity from the amino group. The presence of the cyclohexane ring may contribute to its hydrophobic characteristics, while the aromatic and heterocyclic components can enhance its reactivity and interaction with biological systems. Such compounds may be of interest in medicinal chemistry for their potential therapeutic applications, particularly in targeting specific biological pathways. The trans configuration suggests a specific spatial arrangement of substituents, which can influence the compound's biological activity and physical properties, such as solubility and melting point. Overall, this compound represents a fascinating intersection of organic chemistry and pharmacology.

Formula: C₂₂H₂₆N₄O₃

InChI: InChI=1/C22H26N4O3/c1-22(2)19(26-18-20(23)24-12-25-21(18)29-22)16-9-7-15(8-10-16)14-5-3-13(4-6-14)11-17(27)28/h7-10,12-14H,3-6,11H2,1-2H3,(H,27,28)(H2,23,24,25)/t13-,14-

InChI key: InChIKey=FUIYMYNYUHVDPT-HDJSIYSDNA-N

SMILES: CC1(C)C(=NC=2C(O1)=NC=NC2N)C3=CC=C(C=C3)[C@@H]4CC[C@@H](CC(O)=O)CC4

Synonyms:

• Dgat-3
• T 863
• trans-4-[4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexaneacetic acid
• Cyclohexaneacetic acid, 4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]-, trans-
• T-863;T 863
• 2-((1,4-trans)-4-(4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)- phenyl)cyclohexyl)acetic acid
• trans-2-(4-(4-(4-aMino-7,7-diMethyl-7H-pyriMido[4,5-b][1,4]oxazin-6-yl)phenyl)cyclohexyl)acetic acid
• Mino-7,7-diMethyl-2-((1r,4r)-4-(4-(4-a7H-pyriMido[4,5-b][1,4]oxazin-6-yl)phenyl)cyclohexyl)acetic acid
• trans-Cyclohexaneacetic-acid,-4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]
• CS-120

DGAT-3

CAS: 701232-20-4

Formula: C₂₂H₂₆N₄O₃

Purity: %

Color and Shape: Solid

Molecular weight: 394.4668

Ref: IN-DA00FBB3

T863

CAS: 701232-20-4

T863

Purity: ≥98%

Molecular weight: 394.47g/mol

Ref: 54-BUP04215

T863

CAS: 701232-20-4

T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA

Formula: C₂₂H₂₆N₄O₃

Purity: 98.66% - 99.88%

Color and Shape: Solid

Molecular weight: 394.47

Ref: TM-T4681

2-((1R,4R)-4-(4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl)cyclohexyl)acetic acid

CAS: 701232-20-4

Formula: C₂₂H₂₆N₄O₃

Purity: 98%

Molecular weight: 394.475

Ref: 10-F434662

trans-4-[4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexaneacetic acid

Controlled Product

CAS: 701232-20-4

Formula: C₂₂H₂₆N₄O₃

Color and Shape: Neat

Molecular weight: 394.467

Ref: TR-A392600

T863

CAS: 701232-20-4

T863 is a cell-permeant, small molecule inhibitor of fatty acid synthase. It has been shown to reduce the size of fatty liver in mice and improve glucose tolerance in diabetic animals. T863 inhibits fatty acid synthesis by binding to the carboxyl group on the enzyme's active site and blocking the esterification of malonyl-CoA to acetyl-CoA. T863 also decreases diacylglycerol synthesis and increases protein synthesis in liver cells. This agent has pharmacokinetic properties that allow it to be administered orally, which may make it an attractive treatment option for patients with hepatic steatosis or type 2 diabetes mellitus.

Formula: C₂₂H₂₆N₄O₃

Purity: Min. 95%

Molecular weight: 394.47 g/mol

Ref: 3D-BDB23220