CAS 70641-51-9

Edelfosine

Description:

Edelfosine, with the CAS number 70641-51-9, is a synthetic alkylphospholipid that exhibits unique properties and potential therapeutic applications, particularly in oncology. It is characterized by its amphiphilic structure, which includes a hydrophobic alkyl chain and a hydrophilic phospholipid head group, allowing it to interact with cell membranes effectively. Edelfosine is known for its ability to induce apoptosis in cancer cells, making it a subject of interest in cancer research. Additionally, it has been shown to modulate various signaling pathways, including those involved in cell survival and proliferation. The substance is typically administered in a lipid formulation, enhancing its bioavailability and therapeutic efficacy. Edelfosine's mechanism of action involves the disruption of lipid rafts in cell membranes, leading to altered cellular signaling and increased sensitivity to chemotherapeutic agents. Its safety profile and pharmacokinetics are still under investigation, but it has demonstrated promise in clinical trials for treating certain types of malignancies. Overall, Edelfosine represents a novel approach in cancer therapy, leveraging its unique chemical characteristics for targeted treatment.

Formula: C₂₇H₅₈NO₆P

InChI: InChI=1S/C27H58NO6P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-23-32-25-27(31-5)26-34-35(29,30)33-24-22-28(2,3)4/h27H,6-26H2,1-5H3

InChI key: InChIKey=MHFRGQHAERHWKZ-UHFFFAOYSA-N

SMILES: C(COP(OCC[N+](C)(C)C)(=O)[O-])(COCCCCCCCCCCCCCCCCCC)OC

Synonyms:

• (2R)-2-methoxy-3-(octadecyloxy)propyl 2-(trimethylammonio)ethyl phosphate
• 1-O-Octadecyl-2-O-Methyl-Sn-Glycero-3-Phosphocholine
• 1-O-Octadecyl-2-O-methyl-rac-glyceryl-3-phosphorylcholine
• 1-Octadecyl-2-methylglycero-3-phosphorylcholine
• 2-Methoxy-3-(Octadecyloxy)Propyl 2-(Trimethylammonio)Ethyl Phosphate
• 3,5,9-Trioxa-4-phosphaheptacosan-1-aminium, 4-hydroxy-7-methoxy-N,N,N-trimethyl-, hydroxide, inner salt, 4-oxide, (+-)-
• 3,5,9-Trioxa-4-phosphaheptacosan-1-aminium, 4-hydroxy-7-methoxy-N,N,N-trimethyl-, inner salt, 4-oxide
• Brn 4358577
• Choline hydroxide, (+-)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate, inner salt
• ET 18-OCH₃
• ET-18-OMe
• Edelfosina
• Edelfosina [INN-Spanish]
• Edelfosine [INN]
• Edelfosinum
• Edelfosinum [INN-Latin]
• Et 18-Och3
• NSC 324368
• NSC 343649
• Racemic 1-O-octadecyl-2-O-methylglycero-3-phosphocholine
• Ro 14-5243
• Unii-1Y6Sna8L5S
• rac-1-Octadecyl-2-methoxyglycero-3-phosphocholine

1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphocholine

CAS: 70641-51-9

Edelfosine showed an antimetastatic effect in experimental tumors. Moreover, according to the results of Varela et al., the phospholipid could find use as an orally administered antileishmanial drug.

Formula: C₂₇H₅₈NO₆P

Purity: > 99%

Color and Shape: White Solid Material

Molecular weight: 523.73

Ref: 01-4030361

1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphocholine

CAS: 70641-51-9

Edelfosine is a phospholipid that selectively binds to nuclear DNA, leading to apoptosis. It also binds to the G-protein coupled receptors and inhibits the release of Ca2+ from intracellular stores. Edelfosine has been shown to inhibit the growth of Leishmania in vitro as well as in vivo. This drug is being studied for its potential use in inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis.

Formula: C₂₇H₅₈NO₆P

Purity: Min. 95%

Molecular weight: 523.73 g/mol

Ref: 3D-FO111151