CAS 70648-26-9

1,2,3,4,7,8-Hexachlorodibenzofuran

Description:

1,2,3,4,7,8-Hexachlorodibenzofuran (CAS 70648-26-9) is a chlorinated aromatic compound belonging to the dibenzofuran family. It is characterized by the presence of six chlorine atoms substituted on the dibenzofuran structure, which consists of two fused benzene rings connected by an oxygen atom. This compound is typically a white to off-white solid and is known for its persistence in the environment, as well as its potential for bioaccumulation in living organisms. 1,2,3,4,7,8-Hexachlorodibenzofuran is classified as a polychlorinated dibenzofuran (PCDF), which are known for their toxicological effects, including carcinogenicity and endocrine disruption. Its production and use are largely restricted due to environmental and health concerns. The compound is often monitored in environmental samples, particularly in relation to industrial processes and waste management, as it can be released as a byproduct of combustion and other chemical processes. Proper handling and disposal are crucial to mitigate its environmental impact.

Formula: C₁₂H₂Cl₆O

InChI: InChI=1S/C12H2Cl6O/c13-4-1-3-6(2-5(4)14)19-12-7(3)8(15)9(16)10(17)11(12)18/h1-2H

InChI key: InChIKey=LVYBAQIVPKCOEE-UHFFFAOYSA-N

SMILES: ClC1=C2C=3C(OC2=C(Cl)C(Cl)=C1Cl)=CC(Cl)=C(Cl)C3

Synonyms:

• 1,2,3,4,7,8-Hcdf
• 1,2,3,4,7,8-Hexachlorodibenzofuran
• 1,2,3,4,7,8-HxCDF
• F 118
• Pcdf 118
• Dibenzofuran, 1,2,3,4,7,8-hexachloro-

1,2,3,4,7,8-Hexachlorodibenzofuran

CAS: 70648-26-9

1,2,3,4,7,8-Hexachlorodibenzofuran (1,2,3,4,7,8-HxCDF) enhances the expression of CYP1A1, CYP1B1, and aryl hydrocarbon receptor repressor (AhRR) genes in human peripheral blood lymphocytes (PBL). It can activate ethoxyresorufin-O-deethylase (EROD), with a BMR20TCDD within the range of 0.115-0.143 nM, corresponding to 20% of the maximum response induced by TCDD.

Formula: C₁₂H₂Cl₆O

Color and Shape: Solid

Molecular weight: 374.86

Ref: TM-T203608

1,2,3,4,7,8-Hexachlorodibenzofuran 50 µg/mL in Nonane

CAS: 70648-26-9

Formula: C₁₂H₂Cl₆O

Color and Shape: Single Solution

Molecular weight: 374.86

Ref: 04-A14171750NO-50

1,2,3,4,7,8-Hexachlorodibenzofuran

CAS: 70648-26-9

Formula: C₁₂H₂Cl₆O

Molecular weight: 374.85

Ref: 4Z-B-104019

1,2,3,4,7,8-Hexachlorodibenzofuran (>90%)

CAS: 70648-26-9

Applications 1,2,3,4,7,8-hexachlorodibenzofuran, is a toxic polychlorinated dibenzofurans (PCDD/F), detected in domestic meat and poultry. It can be used as purified standards for analytical, toxic, and biological studies of these environmental contaminants.
References Huwe, J., et al.: Food Addit. Contam., 21, 182 (2004), Llobet, J., et al.: Toxicol. Lett., 178, 117 (2008); Feil, V., et al.: J. Agric. Food Chem., 48, 6163 (2000); Safe, S. H., et al.: J. Agric. Food Chem., 32, 68 (1984);

Formula: C₁₂H₂Cl₆O

Purity: >90%

Color and Shape: White To Light Yellow

Molecular weight: 374.86

Ref: TR-H265095