CAS 706779-91-1

Pimavanserin

Description:

Pimavanserin is an atypical antipsychotic primarily used in the treatment of Parkinson's disease psychosis. It is classified as a selective serotonin inverse agonist, specifically targeting the 5-HT2A receptor, which distinguishes it from traditional antipsychotics that often block dopamine receptors. This unique mechanism allows Pimavanserin to alleviate psychotic symptoms without exacerbating motor symptoms associated with Parkinson's disease. The compound is typically administered orally and has a favorable pharmacokinetic profile, with a relatively long half-life that supports once-daily dosing. Its chemical structure includes a complex arrangement of aromatic rings and heteroatoms, contributing to its specific receptor affinity and therapeutic effects. Pimavanserin is generally well-tolerated, with a side effect profile that is distinct from other antipsychotics, making it a valuable option for patients with Parkinson's-related psychosis. As with any medication, monitoring for potential side effects and interactions is essential during treatment.

Formula: C₂₅H₃₄FN₃O₂

InChI: InChI=1S/C25H34FN3O2/c1-19(2)18-31-24-10-6-20(7-11-24)16-27-25(30)29(23-12-14-28(3)15-13-23)17-21-4-8-22(26)9-5-21/h4-11,19,23H,12-18H2,1-3H3,(H,27,30)

InChI key: InChIKey=RKEWSXXUOLRFBX-UHFFFAOYSA-N

SMILES: N(CC1=CC=C(F)C=C1)(C(NCC2=CC=C(OCC(C)C)C=C2)=O)C3CCN(C)CC3

Synonyms:

• 1-(4-Fluorobenzyl)-1-(1-Methylpiperidin-4-Yl)-3-[4-(2-Methylpropoxy)Benzyl]Urea
• 1-(4-Fluorobenzyl)-3-(4-isobutoxybenzyl)-1-(1-methylpiperidin-4-yl)urea
• 1-[(4-Fluorophenyl)methyl]-1-(1-methylpiperidin-4-yl)-3-[[4-(2-methylpropoxy)phenyl]methyl]urea
• N-(4-Fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-[[4-(2-methylpropyloxy)phenyl]methyl]carbamide
• N-[(4-Fluorophenyl)methyl]-N-(1-methyl-4-piperidinyl)-N′-[[4-(2-methylpropoxy)phenyl]methyl]urea
• Nuplazid
• Urea, N-[(4-fluorophenyl)methyl]-N-(1-methyl-4-piperidinyl)-N′-[[4-(2-methylpropoxy)phenyl]methyl]-
• Pimavanserin

pimavanserin

CAS: 706779-91-1

Formula: C₂₅H₃₄FN₃O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 427.5548

Ref: IN-DA00F9YQ

Pimavanserin Hemitartrate

CAS: 706779-91-1, 706782-28-7

Formula: C₂₅H₃₄FN₃O₂·5C₄H₆O₆

Color and Shape: White To Off-White Solid

Molecular weight: 427.56 0.5*150.09

Ref: 4Z-P-281002

Pimavanserin

CAS: 706779-91-1

Formula: C₂₅H₃₄FN₃O₂

Color and Shape: White To Off-White Solid

Molecular weight: 427.56

Ref: 4Z-P-281001

Pimavanserin-d4

CAS: 706779-91-1

Formula: C₂₅H₃₀D₄FN₃O₂

Color and Shape: White To Off-White Solid

Molecular weight: 431.59

Ref: 4Z-P-281003

Pimavanserin

CAS: 706779-91-1

Pimavanserin

Purity: ≥95%

Molecular weight: 427.55g/mol

Ref: 54-BUP11742

Pimavanserin

Controlled Product

CAS: 706779-91-1

Formula: C₂₅H₃₄FN₃O₂

Color and Shape: Neat

Molecular weight: 427.55

Ref: 86-MM3578.01

Pimavanserin

CAS: 706779-91-1

Pimavanserin is a potent 5-HT2A inverse agonist, used to treat Parkinson's psychosis.

Formula: C₂₅H₃₄FN₃O₂

Purity: 97.84% - 99.69%

Color and Shape: Pale Yellow To Pale Orange Solid

Molecular weight: 427.55

Ref: TM-T2076

Pimavanserin

CAS: 706779-91-1

Inverse agonist of 5-HT2A serotonin receptor; anti-psychotic

Formula: C₂₅H₃₄FN₃O₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 427.55 g/mol

Ref: 3D-FP27045

Pimavanserin

Controlled Product

CAS: 706779-91-1

Applications Drug used in the treatment of Parkinson’s disease and psychosis.
References Snigdha, S., et al.: J. Pharmacol. Exper. Ther., 332, 622 (2010), Meltzer, H., et al.: Neuropsychopharmacol., 35, 881 (2010),

Formula: C₂₅H₃₄FN₃O₂

Color and Shape: Neat

Molecular weight: 427.55

Ref: TR-P441800

4-[(E)-(1-methyl-4-piperidyl)iminomethyl]phenol

Controlled Product

CAS: 706779-91-1

Applications 4-[(E)-(1-methyl-4-piperidyl)iminomethyl]phenol is an impurity of Pimavanserin (P441800), which is a drug used in the treatment of Parkinson’s disease and psychosis.
References Snigdha, S., et al.: J. Pharmacol. Exper. Ther., 332, 622 (2010), Meltzer, H., et al.: Neuropsychopharmacol., 35, 881 (2010)

Formula: C₁₃H₁₈N₂O

Color and Shape: Neat

Molecular weight: 218.295

Ref: TR-E521543

1,1-bis[(4-Fluorophenyl)methyl]-3-[(4-isobutoxyphenyl)methyl]urea

Controlled Product

CAS: 706779-91-1

Formula: C₂₆H₂₈F₂N₂O₂

Color and Shape: Neat

Molecular weight: 438.51

Ref: TR-F632235

1-Benzyl-3-[(4-isobutoxyphenyl)methyl]-1-(1-methyl-4-piperidyl)urea

Controlled Product

CAS: 706779-91-1

Formula: C₂₅H₃₅N₃O₂

Color and Shape: Neat

Molecular weight: 409.564

Ref: TR-B281563

N,N-bis[(4-fluorophenyl)methyl]piperidin-4-amine

Controlled Product

CAS: 706779-91-1

Formula: C₁₉H₂₂F₂N₂

Color and Shape: Neat

Molecular weight: 316.388

Ref: TR-B410973

Pimavanserin-d9

Controlled Product

CAS: 706779-91-1

Formula: C₂₅D₉H₂₅FN₃O₂

Color and Shape: Neat

Molecular weight: 436.61

Ref: TR-P441802

Pimavanserin Impurity 20

CAS: 706779-91-1

Formula: C₂₅H₃₄FN₃O₂

Molecular weight: 427.6

Ref: ST-EA-CP-P112020