CAS 70967-90-7

N-(4-methoxy-4-oxobutanoyl)-L-alanyl-L-alanyl-N-{(2S)-3-methyl-2-[(4-nitrophenyl)amino]butanoyl}-L-prolinamide

Description:

N-(4-methoxy-4-oxobutanoyl)-L-alanyl-L-alanyl-N-{(2S)-3-methyl-2-[(4-nitrophenyl)amino]butanoyl}-L-prolinamide, with CAS number 70967-90-7, is a complex organic compound characterized by its multi-functional structure, which includes amino acid residues and various substituents. This compound features a prolinamide backbone, which is indicative of its potential biological activity, particularly in peptide synthesis or as a pharmaceutical intermediate. The presence of a methoxy group and a nitrophenyl moiety suggests that it may exhibit unique electronic properties and reactivity, potentially influencing its solubility and interaction with biological targets. The stereochemistry, indicated by the presence of L-amino acids, is crucial for its biological function, as chirality can significantly affect the compound's pharmacodynamics and pharmacokinetics. Overall, this substance may be of interest in medicinal chemistry and drug development, particularly in the design of peptide-based therapeutics or inhibitors. Further studies would be necessary to elucidate its specific properties and potential applications.

Formula: C₂₇H₃₈N₆O₉

InChI: InChI=1/C27H38N6O9/c1-15(2)23(30-18-8-10-19(11-9-18)33(40)41)26(38)31-25(37)20-7-6-14-32(20)27(39)17(4)29-24(36)16(3)28-21(34)12-13-22(35)42-5/h8-11,15-17,20,23,30H,6-7,12-14H2,1-5H3,(H,28,34)(H,29,36)(H,31,37,38)/t16-,17-,20-,23-/m0/s1

SMILES: CC(C)[C@@H](C(=O)N=C([C@@H]1CCCN1C(=O)[C@H](C)N=C([C@H](C)N=C(CCC(=O)OC)O)O)O)Nc1ccc(cc1)N(=O)=O

Synonyms:

• N-Methoxysuccinyl-Ala-Ala-Pro-Val P-Nitroanilide
• METHOXYSUCCINYL-ALA-ALA-PRO-VAL-P-NITROANILIDE
• methyl 4-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-3-methyl-1-(4-nitroanilino)-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoate
• MeOSuc-AAPV-pNA
• MeOSuc-AAPV-pNA, Chromogenic Substrate
• L-Valinamide, N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-nitrophenyl)-
• MEO-SUC-ALA-ALA-PRO-VAL-PARANITROANILIDE
• METHOXYSUCCINYL-ALA-ALA-PRO-VAL-P-NITROANILIDE, METHANOL ADDUCT
• LEUKOCYTE ESTERASE SUBSTRATE
• ELASTASE SUBSTRATE I, COLORIMETRIC
• N-methoxysuccinyl-alanyl-alanyl-prolyl-valine-4-nitroanilide
• N-(Methoxysuccinyl)-Ala-Ala-Pro-Val 4-nitroanilide
• N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE, BIOCHEMIKA
• N(methoxysuccinyl)-L-alanyl-L-alanyl-L-prolyl-L-valine NA
• Elastase Substrate I, Colorimetric - CAS 70967-90-7 - Calbiochem
• N-(Methoxysuccinyl)-Ala-Ala-Pro-Val 4-nitroanilide, N-(Methoxysuccinyl)-L-alanyl-L-alanyl-L-prolyl-L-valine 4-nitroanilide
• N-(METHOXYSUCCINYL)-L-ALANYL-L-ALANYL-L-PROLYL-L-VALINE 4-NITROANILIDE
• M4765
• MEOSUC-ALA-ALA-PRO-VAL-PNA

MeOSuc-Ala-Ala-Pro-Val-pNA

CAS: 70967-90-7

An excellent, highly soluble and specific substrate for a routine assay of human and rat leukocyte and porcine pancreatic elastases. MeOSuc-AAPV-pNA is also cleaved by myeloblastin.

Formula: C₂₇H₃₈N₆O₉

Purity: > 98%

Color and Shape: White Powder

Molecular weight: 590.63

Ref: 01-4004221

MeOSuc-AAPV-pNA, Chromogenic Substrate

CAS: 70967-90-7

Formula: C₂₇H₃₈N₆O₉

Purity: 95%

Color and Shape: Solid

Molecular weight: 590.6254

Ref: IN-DA005PEB

MeOSuc-AAPV-pNA

CAS: 70967-90-7

PR3 and neutrophil elastase, degrading matrix proteins for defense, are quantified using MeOSuc-AAPV-pNA, detectable at 405 nm.

Formula: C₂₇H₃₈N₆O₉

Color and Shape: Solid

Molecular weight: 590.63

Ref: TM-T38363

N-Methoxysuccinyl-Ala-Ala-Pro-Val p-Nitroanilide

CAS: 70967-90-7

Applications N-Methoxysuccinyl-Ala-Ala-Pro-Val p-Nitroanilide is a highly sensitive peptide substrate that is hydrolyzed by both human and mouse neutrophil elastase and PR3 but not cathespin.
References Rao. N. et al.: J. Biol., 266, 9450 (1991); Mantovani, A. et al.: Nat. Rev. Immunol., 11, 519 (2011);

Formula: C₂₇H₃₈N₆O₉

Color and Shape: Neat

Molecular weight: 590.63

Ref: TR-M268300

MeOSuc-Ala-Ala-Pro-Val-pNA

CAS: 70967-90-7

MeOSuc-Ala-Ala-Pro-Val-pNA is specific chromogenic substrate for human elastase.

Formula: C₂₇H₃₈N₆O₉

Purity: Min. 95%

Molecular weight: 590.63 g/mol

Ref: 3D-FM110732