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CAS 71320-77-9

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Moclobemide

Description:
Moclobemide is a reversible inhibitor of monoamine oxidase A (RIMA) primarily used as an antidepressant. It is classified as an aromatic amine and is known for its selective action on the monoamine oxidase enzyme, which plays a crucial role in the metabolism of neurotransmitters such as serotonin, norepinephrine, and dopamine. This selectivity allows moclobemide to enhance mood and alleviate symptoms of depression with a lower risk of dietary restrictions compared to irreversible MAO inhibitors. The substance is typically administered orally and is well-absorbed in the gastrointestinal tract. Moclobemide has a relatively short half-life, necessitating multiple daily doses for optimal therapeutic effect. Common side effects may include insomnia, dizziness, and gastrointestinal disturbances. Its pharmacokinetics involve extensive hepatic metabolism, and it is primarily excreted in urine. Due to its mechanism of action, moclobemide is also explored for use in anxiety disorders and social phobia, making it a versatile option in psychiatric treatment.
Formula:C13H17ClN2O2
InChI:InChI=1S/C13H17ClN2O2/c14-12-3-1-11(2-4-12)13(17)15-5-6-16-7-9-18-10-8-16/h1-4H,5-10H2,(H,15,17)
InChI key:InChIKey=YHXISWVBGDMDLQ-UHFFFAOYSA-N
SMILES:C(NCCN1CCOCC1)(=O)C2=CC=C(Cl)C=C2
Synonyms:
  • 4-Chloro-N-(2-morpholin-4-ylethyl)benzamide
  • 4-Chloro-N-(2-morpholinoethyl)benzamide
  • 4-Chloro-N-[2-(4-morpholinyl)ethyl]benzamide
  • Auromid
  • Aurorix
  • Manerix
  • Moclaime
  • Moclobemide
  • Ro 11-1163
  • Ro 11-1163/000
  • See more synonyms
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