CAS 71486-22-1

Vinorelbine

Description:

Vinorelbine is a semi-synthetic vinca alkaloid derived from the periwinkle plant, specifically from the species Catharanthus roseus. It is primarily used as a chemotherapeutic agent in the treatment of various cancers, including non-small cell lung cancer and breast cancer. Vinorelbine functions by inhibiting microtubule formation, thereby disrupting mitosis and preventing cancer cell proliferation. The compound is characterized by its complex structure, which includes a core structure of a vindoline and an additional nitrogen-containing moiety. Vinorelbine is typically administered intravenously and has a moderate side effect profile, which may include neutropenia, nausea, and fatigue. Its pharmacokinetics involve hepatic metabolism, and it is primarily excreted through the bile. The drug's efficacy and safety profile make it a valuable option in oncological therapies, although its use must be carefully monitored due to potential interactions with other medications and the risk of adverse effects. Overall, vinorelbine represents an important tool in the arsenal against cancer, contributing to improved patient outcomes in specific malignancies.

Formula: C₄₅H₅₄N₄O₈

InChI: InChI=1S/C45H54N4O8/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3/t28-,37-,38+,39+,42+,43+,44-,45-/m0/s1

InChI key: InChIKey=GBABOYUKABKIAF-IELIFDKJSA-N

SMILES: C(C)[C@@]12[C@]3([C@@]4([C@]([C@](C(OC)=O)(O)[C@@H]1OC(C)=O)(N(C)C=5C4=CC(=C(OC)C5)[C@]6(C(OC)=O)C7=C(C=8C(N7)=CC=CC8)C[N@@]9C[C@](C6)(C=C(CC)C9)[H])[H])CCN3CC=C2)[H]

Synonyms:

• Vinorelbine
• Nor-5′-anhydrovinblastine
• Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)-
• C′-Norvincaleukoblastine, 3′,4′-didehydro-4′-deoxy-
• KW 2307 base

Vinorelbine

CAS: 71486-22-1

Formula: C₄₅H₅₄N₄O₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 778.9323

Ref: IN-DA0066OM

Vinorelbine

CAS: 71486-22-1

Vinorelbine, a semisynthetic vinca alkaloid, inhibits tubulin, blocking mitotic spindle formation and tumor growth.

Formula: C₄₅H₅₄N₄O₈

Purity: 98.62% - 99.99%

Color and Shape: Solid

Molecular weight: 778.93

Ref: TM-T0190

Vinorelbine

CAS: 71486-22-1

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 778.93

Ref: 7W-GP8758

Vinorelbine

CAS: 71486-22-1

Vinorelbine

Formula: C₄₅H₅₄N₄O₈

Purity: ≥98%

Color and Shape: Solid

Molecular weight: 778.93

Ref: 54-BUP00038

Vinorelbine

CAS: 71486-22-1

Vinorelbine

Formula: C₄₅H₅₄N₄O₈

Color and Shape: Solid-Crystals

Molecular weight: 778.93226

Ref: 54-BIFK0007

Vinorelbine

CAS: 71486-22-1

Formula: C₄₅H₅₄N₄O₈

Purity: 95%~99%

Molecular weight: 778.947

Ref: BP-BP1445

Vinorelbine

Controlled Product

CAS: 71486-22-1

Microtubule disrupter; anti-mitotic drug; anti-cancer alkaloid

Formula: C₄₅H₅₄N₄O₈

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 778.93 g/mol

Ref: 3D-FV61477

Vinorelbine

CAS: 71486-22-1

Formula: C₄₅H₅₄N₄O₈

Molecular weight: 778.95

Ref: ST-EA-CP-V49000