CAS 714971-09-2

BMS-599626

Description:

BMS-599626, with the CAS number 714971-09-2, is a small molecule inhibitor primarily developed for therapeutic applications in oncology. It functions as a selective inhibitor of the protein kinase BRAF, particularly targeting the BRAF V600E mutation, which is commonly associated with various cancers, including melanoma. The compound exhibits a high degree of specificity for its target, which is crucial for minimizing off-target effects and enhancing therapeutic efficacy. BMS-599626 is characterized by its ability to disrupt the signaling pathways that promote tumor growth and survival, making it a candidate for combination therapies in cancer treatment. Its pharmacokinetic properties, such as absorption, distribution, metabolism, and excretion, are designed to optimize its bioavailability and therapeutic window. As with many investigational drugs, ongoing clinical trials are essential to fully elucidate its safety profile, efficacy, and potential side effects in patients. Overall, BMS-599626 represents a significant advancement in targeted cancer therapy, particularly for those with specific genetic mutations.

Formula: C_27H27FN8O3

Synonyms:

• (3S)-3-Morpholinylmethyl (4-{[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino}-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate
• Carbamic acid, N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester
• Ac480
• (3S)-morpholin-3-ylmethyl N-[4-({1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl}amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamate

AC480

CAS: 714971-09-2

Formula: C₂₇H₂₇FN₈O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 530.5535

Ref: IN-DA00FBZJ

BMS-599626

CAS: 714971-09-2

BMS-599626 (AC480) has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.

Formula: C₂₇H₂₇FN₈O₃

Purity: 98.73%

Color and Shape: Solid

Molecular weight: 530.55

Ref: TM-T2610

BMS-599626

CAS: 714971-09-2

Formula: C₂₇H₂₇FN₈O₃

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 530.56

Ref: 3B-B5520

BMS-599626

CAS: 714971-09-2

Ref: 7W-GW8409

AC480 (BMS-599626)

CAS: 714971-09-2

AC480 is a small molecule inhibitor of the epidermal growth factor receptor (EGFR) that has been shown to produce light emission in a variety of cell lines. When AC480 binds to EGFR, it inhibits its kinase activity, which prevents the receptor from transmitting signals that stimulate cell growth. AC480 has a high degree of selectivity for EGFR over other kinases and has been shown to inhibit tumor growth in animal models. In addition, AC480 enhances radiation-induced cell death in prostate cancer cells. This drug also inhibits the production of antibodies associated with autoimmune diseases and may be used to treat these conditions.

Formula: C₂₇H₂₇FN₈O₃

Purity: Min. 95%

Molecular weight: 530.55 g/mol

Ref: 3D-PDB97109