CAS 717907-75-0

N-Methyl-N-[3-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide

Description:

N-Methyl-N-[3-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide, with CAS number 717907-75-0, is a complex organic compound characterized by its unique structural features, including a sulfonamide group, a pyrimidine ring, and an indole derivative. This compound exhibits properties typical of small molecule inhibitors, often utilized in pharmaceutical research for its potential biological activity. The presence of trifluoromethyl and methanesulfonamide groups suggests it may have enhanced lipophilicity and metabolic stability, which are desirable traits in drug design. Additionally, the indole moiety is known for its role in various biological processes, potentially contributing to the compound's pharmacological profile. Its synthesis and characterization would involve standard organic chemistry techniques, and it may be evaluated for its efficacy in targeting specific biological pathways, particularly in the context of cancer or other diseases. As with many such compounds, understanding its solubility, stability, and interaction with biological targets is crucial for its development as a therapeutic agent.

Formula: C₂₁H₂₀F₃N₇O₃S

Synonyms:

• Pf 562271
• Pf-00562271
• n-methyl-n-(3-(((2-((2-oxo-2,3-dihydro-1h-indol-5-yl)amino)-5-trifluoromethylpyrimidin-4-yl)amino)methyl)pyridin-2-yl)methanesulfonamide
• PF-562271 free base
• PF562271/PF-562271
• N-Methyl-N-[3-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)aMino]-5-trifluoroMethylpyriMidin-4-yl]aMino]Methyl]pyridin-2-yl]MethanesulfonaMide (PF-562271)
• N-Methyl-N-[3-[[[2-[(2-oxo-1,3-dihydroindol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide PF-562271
• N-Methyl-N-(3-((2-(2-oxoindolin-5-ylaMino)-5-(trifluoroMethyl)pyriMidin-4-ylaMino)Methyl)pyridin-2-yl)MethanesulfonaMide
• Methanesulfonamide, N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methyl-

PF-562271

CAS: 717907-75-0

PF-562271

Purity: ≥95%

Molecular weight: 507.49g/mol

Ref: 54-BUP12334

PF-562271

CAS: 717907-75-0

Ref: 7W-GW4240

PF-562271

CAS: 717907-75-0

PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).

Formula: C₂₁H₂₀F₃N₇O₃S

Purity: 97.17% - >99.99%

Color and Shape: Solid

Molecular weight: 507.49

Ref: TM-T2465

PF-562271

Controlled Product

CAS: 717907-75-0

Applications PF-56227 is a potent, ATP-competitive, reversible inhibitor of focal adhesion kinase (FAK). Potent FAK inhibitor.
References Infante, J., et al.: J. Clin. Oncol., 30, 1527 (2012); Lee, B., et al.: Mol. Cancer Ther., 13, 190 (2014)

Formula: C₂₁H₂₀F₃N₇O₃S

Color and Shape: Neat

Molecular weight: 507.49

Ref: TR-P293920

PF 562271

CAS: 717907-75-0

Inhibitor of FAK kinase

Formula: C₂₁H₂₀F₃N₇O₃S

Purity: Min. 95%

Molecular weight: 507.49 g/mol

Ref: 3D-FP103993