CAS 71827-03-7

Ivermectin B1a

Description:

Ivermectin B1a, with the CAS number 71827-03-7, is a macrocyclic lactone derived from the fermentation of the soil bacterium Streptomyces avermitilis. It is a potent antiparasitic agent primarily used in veterinary medicine and has applications in human medicine for treating various parasitic infections. Ivermectin B1a exhibits a broad spectrum of activity against nematodes and ectoparasites, including lice and scabies. The compound functions by binding to glutamate-gated chloride channels, leading to increased permeability of the cell membrane to chloride ions, resulting in paralysis and death of the parasites. Ivermectin is generally well-tolerated, with a favorable safety profile, although it can cause side effects in some individuals, particularly at higher doses. The substance is typically administered orally or topically, depending on the type of infection being treated. Its efficacy and safety have made it a critical component in global health initiatives, particularly in combating neglected tropical diseases.

Formula: C₄₈H₇₄O₁₄

InChI: InChI=1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1

InChI key: InChIKey=AZSNMRSAGSSBNP-XPNPUAGNSA-N

SMILES: O[C@]/12[C@@]3(OC\C1=C/C=C/[C@H](C)[C@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)\C(\C)=C\C[C@@]6(C[C@](OC(=O)[C@@]2(C=C(C)[C@H]3O)[H])(C[C@]7(O6)O[C@]([C@H](CC)C)([C@@H](C)CC7)[H])[H])[H])[H]

Synonyms:

• (2aE,4E,5'S,6S,6'R,8E,11R,13R,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-5',6,8,19-tetramethyl-6'-[(1S)-1-methylpropyl]-17-oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl (4xi)-2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-threo-hexopyranoside
• 22,23-Dihydro-5-O-demethylavermectin A1a
• 22,23-Dihydroavermectin B(1)a
• 22,23-Dihydroavermectin B1a
• 22,23-Dihydroavermectin B_1a
• 5-O-Demethyl-22,23-dihydroavermectin A_1a
• Avermectin A1a, 22,23-dihydro-5-O-demethyl-
• Avermectin A_1a, 5-O-demethyl-22,23-dihydro-
• Brn 4643153
• Dihydroavermectin B1a
• Dihydroavermectin B_1a
• Ivermectin B1a
• Ivermectin B_1a
• Spiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2′-[2H]pyran], avermectin A_1a deriv.
• Unii-91Y2202Ouw
• Avermectin A1a, 5-O-demethyl-22,23-dihydro-
• 5-O-Demethyl-22,23-dihydroavermectin A1a

Ivermectin B1a

CAS: 71827-03-7

Ivermectin B1a

Formula: C₄₈H₇₄O₁₄

Purity: ≥95%

Molecular weight: 875.09

Ref: 54-BUP00618

Spiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2'-[2H]pyran], avermectin A1a deriv.

CAS: 71827-03-7

Purity: 97%

Ref: IN-DA00FBJ9

Ivermectin B1a-d2

CAS: 71827-03-7

Formula: C₄₈H₇₂D₂O₁₄

Color and Shape: White To Off-White Solid

Molecular weight: 877.12

Ref: 4Z-I-077008

Ivermectin B1a

CAS: 71827-03-7

Formula: C₄₈H₇₄O₁₄

Color and Shape: White To Off-White Solid

Molecular weight: 875.11

Ref: 4Z-I-077016

Ivermectine B1a

CAS: 71827-03-7

Color and Shape: Neat

Ref: 04-CA14488005

Ivermectin B1a

CAS: 71827-03-7

Ivermectin B1a is the major (80%) component of commercially available ivermectin and a derivative of Avermectin B1a.

Formula: C₄₈H₇₄O₁₄

Purity: 96.18% - ≥98%

Color and Shape: White Solid

Molecular weight: 875.09

Ref: TM-T21727

Ivermectin B1a-D2

Controlled Product

CAS: 71827-03-7

Applications Ivermectin B1a-D2 is a deuterium labelled analogue of Ivermectin B1a (I940815), which is a major component of Ivermectin (I940800), a semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Antihelmintic (Onchocerca). An invitro inhibitor of SARS-CoV-2/ Covid-19.
References Chabala, J.C., et al.: J. Med. Chem., 23, 1134 (1980); Campbell, W.C., et al.: Science, 221, 823 (1983); Bennett, J.L., et al.: Parasitol. Today, 4, 226 (1988); Plaisier, A.P., et al.: J. Infect. Dis., 172, 204 (1995);; Caly, L., et al.: Antivir. Res., 178

Formula: C₄₈H₇₂D₂O₁₄

Color and Shape: Neat

Molecular weight: 877.11

Ref: TR-I940817

Ivermectin B1a (>85%)

Controlled Product

CAS: 71827-03-7

Applications Ivermectin B1a is a major component of Ivermectin (I940800), a semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Antihelmintic (Onchocerca). An invitro inhibitor of SARS-CoV-2/ Covid-19.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Chabala, J.C., et al.: J. Med. Chem., 23, 1134 (1980); Campbell, W.C., et al.: Science, 221, 823 (1983); Bennett, J.L., et al.: Parasitol. Today, 4, 226 (1988); Plaisier, A.P., et al.: J. Infect. Dis., 172, 204 (1995);; Caly, L., et al.: Antivir. Res., 178

Formula: C₄₈H₇₄O₁₄

Purity: >85%

Color and Shape: Neat

Molecular weight: 875.09

Ref: TR-I940815

Ivermectin B1a

CAS: 71827-03-7

Ref: BE-RMCI144015

22,23-dihydroavermectin B1a in Methanol

CAS: 71827-03-7

Methanol

Ref: BE-BePure-23738YM-1000

Ivermectin B1a-D2

CAS: 71827-03-7

Ivermectin is a broad-spectrum antiparasitic agent that is used to treat onchocerciasis and other infectious diseases. It binds selectively to gamma-aminobutyric acid (GABA) receptors in the central nervous system and inhibits the release of neurotransmitters, thereby inhibiting the inflammatory response. Ivermectin has been shown to be safe for use in humans and has a long half-life that allows for once-weekly administration. This drug also has pharmacokinetic properties that are similar among different species and clinical studies have shown no significant differences between human and animal models. Ivermectin is applied topically as an ointment or cream or orally as tablets or capsules, depending on the condition being treated.

Formula: C₄₈H₇₂D₂O₁₄

Purity: Min. 95%

Molecular weight: 877.11 g/mol

Ref: 3D-WCA82703

Ivermectin 2-epimer

CAS: 71827-03-7

Formula: C₄₈H₇₄O₁₄

Molecular weight: 875.11

Ref: ST-EA-CP-I18017