CAS 71989-31-6

Fmoc-Pro-OH

Description:

Fmoc-Pro-OH, or 9-fluorenylmethoxycarbonyl-proline, is a protected amino acid commonly used in peptide synthesis. It features a fluorenylmethoxycarbonyl (Fmoc) group, which serves as a protective group for the amino functionality of proline, allowing for selective reactions during peptide assembly. The Fmoc group is stable under basic conditions but can be removed under mild acidic conditions, facilitating the deprotection step in peptide synthesis. Fmoc-Pro-OH is characterized by its relatively high solubility in organic solvents, such as dimethylformamide (DMF) and dichloromethane, while being less soluble in water. This compound is crucial in solid-phase peptide synthesis, where it helps in the sequential addition of amino acids to form peptides. Its structure includes a proline backbone, which introduces unique conformational properties due to its cyclic structure, influencing the overall peptide's secondary structure. The CAS number 71989-31-6 uniquely identifies this compound, ensuring precise communication in scientific literature and databases.

Formula: C₂₀H₁₉NO₄

InChI: InChI=1S/C20H19NO4/c22-19(23)18-10-5-11-21(18)20(24)25-12-17-15-8-3-1-6-13(15)14-7-2-4-9-16(14)17/h1-4,6-9,17-18H,5,10-12H2,(H,22,23)/t18-/m0/s1

InChI key: InChIKey=ZPGDWQNBZYOZTI-SFHVURJKSA-N

SMILES: C(OC(=O)N1[C@H](C(O)=O)CCC1)C2C=3C(C=4C2=CC=CC4)=CC=CC3

Synonyms:

• (2S)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]pyrrolidine-2-carboxylic acid
• (2S)-1-[[(9H-Fluoren-9-yl)methoxy]carbonyl]pyrrolidine-2-carboxylic acid
• (S)-N-(9-Fluorenylmethoxycarbonyl)proline
• (S)-hidrogenopirrolidina-1,2-dicarboxilato de 1-(9H-fluoren-9-ilmetilo)
• (S)-hydrogenopyrrolidine-1,2-dicarboxylate de 1-(9H-fluorene-9-ylmethyle)
• 1,2-Pyrrolidinedicarboxylic acid, 1-(9H-fluoren-9-ylmethyl) ester, (S)-
• 1-(9H-fluoren-9-ylmethyl) hydrogen (S)-pyrrolidine-1,2-dicarboxylate
• 1-(9H-fluoren-9-ylmethyl)-(S)-hydrogenpyrrolidin-1,2-dicarboxylat
• Fluorenylmethoxycarbonylproline
• Fmoc-<span class="text-smallcaps">L</span>-Pro-OH
• Fmoc-<span class="text-smallcaps">L</span>-proline
• Fmoc-L-proline
• Fmoc-Pro-OH
• N-(9-Fluorenylmethoxycarbonyl)-<span class="text-smallcaps">L</span>-proline
• N-(9-Fluorenylmethoxycarbonyl)-L-proline
• N-(9-Fluorenylmethoxycarbonyl)proline
• N-FMOC-<span class="text-smallcaps">L</span>-proline
• N-FMOC-L-proline
• Nsc 334294

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-proline

CAS: 71989-31-6

Formula: C₂₀H₁₉NO₄

Purity: >98.0%(HPLC)(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 337.38

Ref: 3B-F0298

Fmoc-Pro-OH

CAS: 71989-31-6

M03372 - Fmoc-Pro-OH

Formula: C₂₀H₁₉NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 337.375

Ref: 10-M03372

N-Fmoc-L-proline, 98%

CAS: 71989-31-6

It is used as pharmaceutical intermediate. Fmoc method is used for the synthesis of the new polymeric support for the preparation of C-terminal peptide amides. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label inform

Formula: C₂₀H₁₉NO₄

Purity: 98%

Color and Shape: Crystals or powder or crystalline powder, White to pale cream

Molecular weight: 337.38

Ref: 02-B21081

Fmoc-Pro-OH

CAS: 71989-31-6

Bachem ID: 4003150.

Formula: C₂₀H₁₉NO₄

Purity: 99.8%

Color and Shape: White

Molecular weight: 337.38

Ref: 01-4003150

FMOC-Pro-OH

CAS: 71989-31-6

FMOC-Pro-OH

Formula: C₂₀H₁₉NO₄

Purity: 98%

Color and Shape: White Solid

Molecular weight: 337.36916

Ref: 54-OR54567

Fmoc-L-Proline, 10mM (in DMSO)

CAS: 71989-31-6

Fmoc-L-Proline, 10mM (in DMSO)

Formula: C₂₀H₁₉NO₄

Purity: ≥98%, 10 mM in DMSO

Molecular weight: 337.37

Ref: 54-BUP19106

Fmoc-Pro-OH

CAS: 71989-31-6

Formula: C₂₀H₁₉NO₄

Purity: ≥ 99.0%

Color and Shape: White to off-white or pale yellow crystalline powder

Molecular weight: 337.38

Ref: 7W-GM2265

Fmoc-L-Proline

CAS: 71989-31-6

Fmoc-L-Proline (Fmoc-Pro-OH) is a proline derivative.

Formula: C₂₀H₁₉NO₄

Purity: 99.60%

Color and Shape: Solid

Molecular weight: 337.3692

Ref: TM-T64331

L-Proline-2,5,5-d3-N-FMOC

CAS: 71989-31-6

Purity: 98 atom % D

Color and Shape: White Solid

Molecular weight: 340.39

Ref: 3U-D7565

1,2-Pyrrolidinedicarboxylic acid, 1-(9H-fluoren-9-ylmethyl) ester, (2S)-

CAS: 71989-31-6

Formula: C₂₀H₁₉NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 337.3692

Ref: IN-DA003QO0

Fmoc-Pro-OH

CAS: 71989-31-6

Fmoc-Pro-OH

Formula: C₂₀H₁₉NO₄

Purity: 98%

Molecular weight: 337.37

Ref: IN-DG8606

Fmoc-Pro-OH

CAS: 71989-31-6

Formula: C₂₀H₁₉NO₄

Molecular weight: 337.38

Ref: 4Z-P-166009

Fmoc-Pro-OH

CAS: 71989-31-6

Fmoc-Pro-OH is a synthetic cyclic peptide with the amino acid sequence (Fmoc-Lys-Lys-Ala-Glu)n. Fmoc-Pro-OH binds to the androgen receptor and can be used as a research tool to identify other molecules that bind to the same receptor. It has been shown to inhibit the activity of ester hydrochloride, trifluoroacetic acid, and superparamagnetic iron in coordination complexes.

Formula: C₂₀H₁₉NO₄

Purity: Min. 95 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 337.37 g/mol

Ref: 3D-FF15871

Fmoc-Pro-OH

CAS: 71989-31-6

Fmoc-Pro-OH is a peptide that contains the Fmoc protecting group. It is used in the synthesis of peptides and has been shown to be effective against microbial infections with marine sponges. The synthesis of this compound can be carried out on an on-line automated peptide synthesizer. The Fmoc protecting group is removed by treatment with trifluoroacetic acid (TFA) in dichloromethane, which leaves the side chain unprotected. This compound has a high binding affinity for the receptor site of fibrinogen and can potentially inhibit the growth of bacteria that cause bacterial infection, such as Staphylococcus aureus and Pseudomonas aeruginosa.
Fmoc-Pro-OH can also be used to synthesize other functional groups such as sulfamoyl groups or acetonitrile groups, depending on the desired outcome.

Formula: C₂₀H₁₉NO₄

Purity: Min. 98 Area-%

Molecular weight: 337.38 g/mol

Ref: 3D-FLP-1731-PI

L-Proline-2,5,5-d3-N-FMOC

CAS: 71989-31-6

Formula: C₂₀H₁₉NO₄

Molecular weight: 337.4

Ref: BE-MD-4640

Fmoc-L-Proline

CAS: 71989-31-6

Formula: C₂₀H₁₉NO₄

Molecular weight: 337.4

Ref: BE-RMCP341007

FMOC-L-Proline extrapure, 99%

CAS: 71989-31-6

Formula: C₂₀H₁₉NO₄

Purity: min. 99%

Color and Shape: White to Off white, Crystalline powder

Molecular weight: 337.38

Ref: SR-12047

L-Proline-N-Fmoc

Controlled Product

CAS: 71989-31-6

Applications L-Proline-N-Fmoc is N-Fmoc protected L-Proline (P755995) which is an amino acid and precursor (with vitamin C) for collagen, the building block of the structure of tendons, ligaments, arteries, veins and muscles. It is important in wound healing.
References Bondarenko, L.B., et al.: Int. J. Peptides., 2, 1687 (2012); Rimer, T., et al.: Biomacromolecules, 13, 2110 (2012);

Formula: C₂₀H₁₉NO₄

Color and Shape: Neat

Molecular weight: 337.37

Ref: TR-P756005

L-Proline-d3-N-Fmoc

Controlled Product

CAS: 71989-31-6

Applications L-Proline-d3-N-Fmoc was used to prepare potent bombesin-like peptides for GRP-receptor targeting of tumors. It was also used to synthesize tetrapeptide aldehyde inhibitors of dengue virus NS3 protease.
References Nock, B., et al.: J. Med. Chem., 48, 100 (2005); Yin, Z., et al.: Bioorg. Med. Chem. Lett., 16, 40 (2006)

Formula: C₂₀D₃H₁₆NO₄

Color and Shape: Neat

Molecular weight: 340.3877

Ref: TR-P756007