CAS 73030-71-4

Atractylenolide III

Description:

Atractylenolide III is a bioactive compound primarily derived from the roots of the traditional Chinese medicinal herb Atractylodes macrocephala. It belongs to the class of sesquiterpenes and is characterized by its unique chemical structure, which contributes to its various pharmacological properties. This compound is known for its potential anti-inflammatory, anti-cancer, and immunomodulatory effects, making it of interest in both traditional medicine and modern pharmacological research. Atractylenolide III exhibits a range of biological activities, including the ability to inhibit certain enzymes and modulate signaling pathways, which may contribute to its therapeutic effects. Additionally, it has been studied for its protective effects against oxidative stress and its role in enhancing immune responses. The compound is typically extracted and purified for research purposes, and its safety profile is generally considered favorable, although further studies are needed to fully understand its mechanisms of action and potential applications in clinical settings.

Formula: C₁₅H₂₀O₃

InChI: InChI=1/C15H20O3/c1-9-5-4-6-14(3)8-15(17)12(7-11(9)14)10(2)13(16)18-15/h11,17H,1,4-8H2,2-3H3/t11-,14+,15-/m0/s1

InChI key: InChIKey=FBMORZZOJSDNRQ-GLQYFDAESA-N

SMILES: O[C@@]12C(C[C@@]3([C@@](C)(C1)CCCC3=C)[H])=C(C)C(=O)O2

Synonyms:

• (4aS,8aR,9aS)-4a,5,6,7,8,8a,9,9a-Octahydro-9a-hydroxy-3,8a-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one
• (4aS,8aR,9aS)-9a-hydroxy-3,8a-dimethyl-5-methylidene-4a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(4H)-one
• 8β-Hydroxyasterolide
• Atractylenolide III
• Atractylenolide β
• Codonolactone
• Naphtho(2,3-b)furan-2(4H)-one, 4a,5,6,7,8,8a,9,9a-octahydro-9a-hydroxy-3,8a-dimethyl-5-methylene-, (4aS,8aR,9aS)-
• Naphtho[2,3-b]furan-2(4H)-one, 4a,5,6,7,8,8a,9,9a-octahydro-9a-hydroxy-3,8a-dimethyl-5-methylene-, [4aS-(4aα,8aβ,9aβ)]-
• Atractylenolide III, BR
• (4aS,8aR,9aS)-9a-Hydroxy-3,8a-dimethyl-5-methylidene-4,4a,6,7,8,9-hexahydrobenzo[f][1]benzoxol-2-one
• Atractylenolide beta
• 8-HYDROXYASTEROLIDE
• ICodonolactone
• Atracylenolide III
• ATRACTYLENOLIDE
• (4aS)-4a,5,6,7,8,8a,9,9a-Octahydro-9aβ-hydroxy-3,8aβ-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one
• Atractylenolide III (ICodonolactone
• Atractylenolide III USP/EP/BP

Atractylenolide III

CAS: 73030-71-4

Formula: C₁₅H₂₀O₃

Purity: >98.0%(HPLC)(T)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 248.32

Ref: 3B-A3609

Naphtho[2,3-b]furan-2(4H)-one,4a,5,6,7,8,8a,9,9a-octahydro-9a-hydroxy-3,8a-dimethyl-5-methylene-,(4aS,8aR,9aS)-

CAS: 73030-71-4

Formula: C₁₅H₂₀O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 248.3175

Ref: IN-DA00ICC9

Atractylenolide III

CAS: 73030-71-4

Formula: C₁₅H₂₀O₃

Molecular weight: 248.32

Ref: 7W-GL2829

Atractylenolide III

CAS: 73030-71-4

Atractylenolide III

Formula: C₁₅H₂₀O₃

Purity: ≥98%

Molecular weight: 248.32

Ref: 54-BUP10043

Atractylenolide III

CAS: 73030-71-4

Atractylenolide III is the major bioactive component of Atractylodes lancea, it inhibits histamine release, suppresses activation of p38 mitogen-activated protein kinase, C-Jun-N-terminal protein kinase, and nuclear factor-κB in stimulated HMC-1 cells, and suppresses the activation of caspase-1 and the expression of receptor interacting protein-2, suggests that atractylenolide III may control immunological reactions by regulating the cellular functions of IL-6 in mast cells.

Formula: C₁₅H₂₀O₃

Purity: 95%~99%

Color and Shape: White cryst.

Molecular weight: 248.322

Ref: BP-BP0216

Atractylenolide III (Standard)

CAS: 73030-71-4

Atractylenolide III (Standard) is a reference standard for research and analysis in studies involving Atractylenolide III. Atractylenolide III (ICodonolactone) may have therapeutic potential in treating homocysteine-mediated cognitive impairment and neuronal injury. Atractylenolide III is a potential candidate for the treatment of human lung carcinoma by inducing the release of cytochrome c, upregulating the expression of Bax and translocating apoptosis-inducing factor.

Formula: C₁₅H₂₀O₃

Molecular weight: 248.3175

Ref: TM-TMSM-0743

Atractylenolide III

CAS: 73030-71-4

Atractylenolide III could treat cognitive issues and lung cancer by modulating apoptosis factors.

Formula: C₁₅H₂₀O₃

Purity: 99.63% - 99.98%

Color and Shape: Solid

Molecular weight: 248.3175

Ref: TM-T3902

Atractylenolide III

CAS: 73030-71-4

(4aS,8aR,9aS)-9a-Hydroxy-3,8a-dimethyl-5-methylene-4a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(4H)-one

Formula: C₁₅H₂₀O₃

Purity: 98%

Molecular weight: 248.32

Ref: IN-DG34761

Atractylenolide III

CAS: 73030-71-4

Lactone

Formula: C₁₅H₂₀O₃

Purity: ≥ 98.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 248.32

Ref: 5G-80359

Atracylenolide III

CAS: 73030-71-4

Formula: C₁₅H₂₀O₃

Molecular weight: 248.32

Ref: BE-RMT10390

AtractylenolideIII

CAS: 73030-71-4

Atractylenolide III is a sesquiterpene lactone, which is derived from the rhizomes of Atractylodes macrocephala, a plant commonly used in traditional Chinese medicine. With its origin in botanical sources, the compound is notable for its diverse biological activities and mechanisms of action. Atractylenolide III exerts its effects primarily through the modulation of various signaling pathways, including anti-inflammatory, anti-cancer, and immunomodulatory pathways. It inhibits the production of pro-inflammatory cytokines and regulates the expression of key signaling proteins, thus impacting cellular processes such as proliferation, apoptosis, and differentiation. The compound shows promise in the treatment of conditions like cancer, inflammation, and immune disorders. Researchers continue to explore its potential benefits, seeking to elucidate the molecular mechanisms underlying its therapeutic effects and to optimize its application in various biomedical fields.

Purity: Min. 95%

Ref: 3D-FA73865