CAS 73032-94-7

somatostatin 28

Description:

Somatostatin 28 is a peptide hormone that plays a crucial role in the regulation of various physiological processes, including the inhibition of growth hormone release and modulation of insulin and glucagon secretion. It is a member of the somatostatin family, which consists of several isoforms, with somatostatin 28 being one of the longer forms, derived from the preprosomatostatin precursor. This peptide is composed of 28 amino acids and exhibits a cyclic structure that contributes to its stability and biological activity. Somatostatin 28 is primarily produced in the hypothalamus and gastrointestinal tract, where it acts on specific receptors to exert its effects. Its functions extend to the central nervous system, where it influences neurotransmission and neuroendocrine signaling. The CAS number 73032-94-7 uniquely identifies this compound in chemical databases, facilitating research and application in pharmacology and biochemistry. Overall, somatostatin 28 is significant in both clinical and research settings, particularly in understanding hormonal regulation and potential therapeutic applications in endocrine disorders.

Formula: C₁₃₇H₂₀₇N₄₁O₃₉S₃

InChI: InChI=1/C137H207N41O39S3/c1-69(154-113(194)82(37-19-22-47-138)159-115(196)85(40-25-50-149-136(145)146)160-118(199)87(44-45-106(188)189)163-116(197)86(41-26-51-150-137(147)148)164-130(211)101-43-27-52-177(101)133(214)72(4)156-114(195)88(46-54-218-7)158-110(191)71(3)155-129(210)100-42-28-53-178(100)134(215)95(61-104(144)186)171-126(207)96(65-180)172-124(205)93(59-102(142)184)165-111(192)70(2)153-112(193)80(141)64-179)109(190)152-63-105(187)157-98-67-219-220-68-99(135(216)217)174-127(208)97(66-181)173-132(213)108(74(6)183)176-125(206)91(57-77-33-15-10-16-34-77)170-131(212)107(73(5)182)175-119(200)84(39-21-24-49-140)161-122(203)92(58-78-62-151-81-36-18-17-35-79(78)81)168-121(202)90(56-76-31-13-9-14-32-76)166-120(201)89(55-75-29-11-8-12-30-75)167-123(204)94(60-103(143)185)169-117(198)83(162-128(98)209)38-20-23-48-139/h8-18,29-36,62,69-74,80,82-101,107-108,151,179-183H,19-28,37-61,63-68,138-141H2,1-7H3,(H2,142,184)(H2,143,185)(H2,144,186)(H,152,190)(H,153,193)(H,154,194)(H,155,210)(H,156,195)(H,157,187)(H,158,191)(H,159,196)(H,160,199)(H,161,203)(H,162,209)(H,163,197)(H,164,211)(H,165,192)(H,166,201)(H,167,204)(H,168,202)(H,169,198)(H,170,212)(H,171,207)(H,172,205)(H,173,213)(H,174,208)(H,175,200)(H,176,206)(H,188,189)(H,216,217)(H4,145,146,149)(H4,147,148,150)

SMILES: CC(C(=NCC(=NC1CSSCC(C(=O)O)N=C(C(CO)N=C(C(C(C)O)N=C(C(Cc2ccccc2)N=C(C(C(C)O)N=C(C(CCCCN)N=C(C(Cc2c[nH]c3ccccc23)N=C(C(Cc2ccccc2)N=C(C(Cc2ccccc2)N=C(C(CC(=N)O)N=C(C(CCCCN)N=C1O)O)O)O)O)O)O)O)O)O)O)O)O)N=C(C(CCCCN)N=C(C(CCCNC(=N)N)N=C(C(CCC(=O)O)N=C(C(CCCNC(=N)N)N=C(C1CCCN1C(=O)C(C)N=C(C(CCSC)N=C(C(C)N=C(C1CCCN1C(=O)C(CC(=N)O)N=C(C(CO)N=C(C(CC(=N)O)N=C(C(C)N=C(C(CO)N)O)O)O)O)O)O)O)O)O)O)O)O

Synonyms:

• H-Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH (Disulfide bond)
• Somatostatin 28, Cyclic

Somatostatin-28

CAS: 73032-94-7

The octacosapeptide somatostatin-28 arises from the posttranslational cleavage of prosomatostatin, which in turn is derived from a larger precursor, preprosomatostatin. S-28 was first isolated from porcine duodenum. In guinea-pig pancreatic acini, S-28, unlike S-14, increased amylase secretion, cellular cyclic GMP, and Ca²⁺ outfluxes.

Formula: C₁₃₇H₂₀₇N₄₁O₃₉S₃

Purity: > 95%

Color and Shape: Whitish Powder

Molecular weight: 3148.6

Ref: 01-4031270

Somatostatin-28

CAS: 73032-94-7

Somatostatin-28 H-Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly (Disulfide bond) is a peptide hormone that is produced in the body by different tissues, including the pancreas. Somatostatin inhibits the release of various hormones, including growth hormone and insulin. It also has been shown to inhibit cell proliferation, tumor growth and angiogenesis in vitro. Somatostatin is used to diagnose diseases such as acute pancreatitis, chronic pancreatitis and prostate cancer. The somatostatin analog octreotide has been shown to reduce symptoms of diarrhea in patients with AIDS.

Formula: C₁₃₇H₂₀₇N₄₁O₃₉S₃

Purity: Min. 95%

Molecular weight: 3,148.56 g/mol

Ref: 3D-FS109420

Somatostatin-28

CAS: 73032-94-7

Somatostatin-28 is the 28 amino acid isoform of somatostatin and has similar activity to the 14 amino acid isoform. While the 14 amino acid form mainly acts in the brain, somatostatin-28 mainly operates in the gastrointestinal tract. Somatostatin is a peptide hormone that is widely expressed throughout the body for example in the gastrointestinal (GI) tract, hypothalamus, pancreas and the central nervous system. It has been found to inhibit pituitary growth hormone release as well as endocrine, pancreatic and GI secretions. In the central nervous system somatostatin plays a role in neurotransmission modification and it has also demonstrated to be effective against a number of cancers such as squamous carcinoma.

Formula: C₁₃₇H₂₀₇N₄₁O₃₉S₃

Purity: Min. 95%

Molecular weight: 3,148.62 g/mol

Ref: 3D-PSI-3747-PI

Somatostatin 28

CAS: 73032-94-7

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Formula: C₁₃₇H₂₀₇N₄₁O₃₉S₃

Color and Shape: White to off-white, Powder

Molecular weight: 3148.58

Ref: 02-J66274