CAS 73069-25-7

Praeruptorin A

Description:

Praeruptorin A is a natural compound classified as a coumarin derivative, primarily extracted from the plant species Peucedanum praeruptorum. It is known for its distinctive structural features, which include a fused benzopyran ring system. This compound exhibits a range of biological activities, including anti-inflammatory, antioxidant, and potential anticancer properties, making it of interest in pharmacological research. Praeruptorin A has been studied for its effects on various cellular pathways, contributing to its therapeutic potential. Its solubility characteristics typically indicate moderate polarity, influencing its bioavailability and interaction with biological systems. Additionally, the compound's stability and reactivity can be affected by environmental factors such as pH and temperature. Overall, Praeruptorin A represents a significant subject of study in natural product chemistry and medicinal applications, highlighting the importance of plant-derived compounds in drug discovery and development.

Formula: C₂₁H₂₂O₇

InChI: InChI=1/C21H22O7/c1-6-11(2)20(24)27-19-18(25-12(3)22)16-14(28-21(19,4)5)9-7-13-8-10-15(23)26-17(13)16/h6-10,18-19H,1-5H3/b11-6-/t18-,19-/m1/s1

InChI key: XGPBRZDOJDLKOT-CIRUDOSSSA-N

SMILES: C/C=C(/C)\C(=O)O[C@@H]1[C@@H](c2c(ccc3ccc(=O)oc23)OC1(C)C)OC(=O)C

Synonyms:

• (-)-Pareruptorin A
• Ccris 7247
• (9R,10R)-10-(acetyloxy)-8,8-dimethyl-2-oxo-9,10-dihydro-2H,8H-pyrano[2,3-f]chromen-9-yl (2Z)-2-methylbut-2-enoate
• (+-)-Praeruptorin A
• (+)-praeruptorin A

(±)-Praeruptorin A

CAS: 73069-25-7

(±)-Praeruptorin A

Formula: C₂₁H₂₂O₇

Purity: ≥98%

Molecular weight: 386.4

Ref: 54-BUP06217

DL-Praeruptorin A

CAS: 73069-25-7

Formula: C₂₁H₂₂O₇

Molecular weight: 386.40

Ref: 7W-GY0704

DL-Praeruptorin A

CAS: 73069-25-7

Praeruptorin A exerts neuroprotective, anti-osteoclastogenic, anti-inflammatory, distinct relaxant effects, it is beneficial to facilitate nestin expression in myocarditis,and suitable in treatment of early myocarditis. Praeruptorin A can significantly up-regulate UGT1A1 expression in HepG2 cells partially via the CAR-mediated pathway. Praeruptorin A inhibited p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca2+ oscillation.

Formula: C₂₁H₂₂O₇

Purity: 95%~99%

Molecular weight: 386.4

Ref: BP-BP0512

(±)-Praeruptorin A (Standard)

CAS: 73069-25-7

(±)-Praeruptorin A (Standard) is a reference standard for research and analysis in studies involving (±)-Praeruptorin A. 1. (±)-Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation 2. Praeruptorin A has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2+)/calmodulin-CaMKIV-CREB-NFATc1 and/or Ca(2+)/calmodulin-calcineurin-NFATc1 signaling axis. 3. Praeruptorin A and praeruptorin C can significantly upregulate multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro, and this should be taken as an herb-drug interaction.

Formula: C₂₁H₂₂O₇

Molecular weight: 386.3952

Ref: TM-TMSM-0705

Praeruptorin A

CAS: 73069-25-7

Applications Praeruptorin A is used in the treatment of cardiac diseases, extracted from Peucedani Radix, it exhibits anti-hypertensive effects. Also a potential anti-tumor agent due to the ability to modulate P-glycoprotein (Pgp), overexpression in MDR tumor cells.
References Song, Y. et al.: Molecules, 17, 4236 (2012); Shen, X. et al.: J. Pharm. Pharmacol., 64 90 (2012);

Formula: C₂₁H₂₂O₇

Color and Shape: Neat

Molecular weight: 386.4

Ref: TR-P699445

(±)-Praeruptorin A

CAS: 73069-25-7

(±)-Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation.

Formula: C₂₁H₂₂O₇

Purity: 98.9% - 99.89%

Color and Shape: Solid

Molecular weight: 386.3952

Ref: TM-T4S1419

Praeruptorin A

CAS: 73069-25-7

Formula: C₂₁H₂₂O₇

Molecular weight: 386.4

Ref: BE-RMT10320

(±)-Praeruptorin A

CAS: 73069-25-7

Formula: C₂₁H₂₂O₇

Purity: 99%

Color and Shape: Solid

Molecular weight: 386.3952

Ref: IN-DA00IKLI