CAS 73610-81-8

N-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)-L-gamma-glutamyl-L-gamma-glutamyl-L-gamma-glutamyl-L-glutamic acid

Description:

N-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)-L-gamma-glutamyl-L-gamma-glutamyl-L-gamma-glutamyl-L-glutamic acid, with CAS number 73610-81-8, is a complex organic compound primarily recognized for its role in medicinal chemistry, particularly in the context of cancer treatment and drug delivery systems. This substance features a pteridine moiety, which is significant in biological systems, especially in the synthesis of nucleotides and amino acids. The presence of multiple gamma-glutamyl residues suggests potential interactions with glutamate receptors or transporters, which may enhance its bioavailability or targeting capabilities in therapeutic applications. The compound's structure indicates it may exhibit solubility in polar solvents, and its molecular weight and functional groups could influence its pharmacokinetics and pharmacodynamics. Overall, this compound exemplifies the intricate design often employed in the development of targeted therapies, aiming to improve efficacy while minimizing side effects in clinical settings.

Formula: C₃₅H₄₃N₁₁O₁₄

InChI: InChI=1/C35H43N11O14/c1-46(15-17-14-38-29-27(39-17)28(36)44-35(37)45-29)18-4-2-16(3-5-18)30(52)43-22(34(59)60)8-12-25(49)41-20(32(55)56)6-10-23(47)40-19(31(53)54)7-11-24(48)42-21(33(57)58)9-13-26(50)51/h2-5,14,19-22H,6-13,15H2,1H3,(H,40,47)(H,41,49)(H,42,48)(H,43,52)(H,50,51)(H,53,54)(H,55,56)(H,57,58)(H,59,60)(H4,36,37,38,44,45)/t19-,20-,21-,22-/m0/s1

SMILES: CN(Cc1cnc2c(c(N)[nH]c(=N)n2)n1)c1ccc(cc1)C(=O)N[C@@H](CCC(=N[C@@H](CCC(=N[C@@H](CCC(=N[C@@H](CCC(=O)O)C(=O)O)O)C(=O)O)O)C(=O)O)O)C(=O)O

NSC 341077

CAS: 73610-81-8

NSC 341077 is a bioactive chemical.

Formula: C₃₅H₄₃N₁₁O₁₄

Color and Shape: Solid

Molecular weight: 841.78

Ref: TM-T33745

Methotrexate Tetraglutamate Trifluoroacetate

CAS: 73610-81-8

Formula: C₃₅H₄₃N₁₁O₁₄·C₂HF₃O₂

Molecular weight: 841.78

Ref: 4Z-M-7024

Methotrexate-d3 Tetraglutamate Trifluoroacetate

Controlled Product

CAS: 432545-63-6, 73610-81-8

Stability Hygroscopic
Applications Methotrexate-d3 Tetraglutamate is the isotope labelled analog of Methotrexate Tetraglutamate (M260730); a metabolite of Methotrexate (M260675) which is a folic acid antagonist, antineoplastic, and antirheumatic.
References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958); Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985)

Formula: C₃₅H₄₀D₃N₁₁O₁₄•(C₂HF₃O₂)x

Color and Shape: Neat

Molecular weight: 844.8

Ref: TR-M260732

Methotrexate Tetraglutamate Trifluoroacetate

Controlled Product

CAS: 73610-81-8

Applications Methotrexate Tetraglutamate is a metabolite of Methotrexate (M260675); a folic acid antagonist, antineoplastic, and antirheumatic.
References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958); Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985)

Formula: C₃₅H₄₃N₁₁O₁₄xC₂HF₃O₂

Color and Shape: Neat

Molecular weight: 841.78

Ref: TR-M260730

Methotrexate tetraglutamate

CAS: 73610-81-8

Methotrexate tetraglutamate is a polyglutamine-containing anticancer drug that has been shown to be effective in the treatment of certain types of cancer. Methotrexate tetraglutamate is an active form of methotrexate, which inhibits the synthesis of DNA and RNA by inhibiting the production of nucleotides. It also binds to glycosylation sites on proteins, leading to inhibition of protein synthesis and cell death. Methotrexate tetraglutamate can be used as an immunosuppressant for autoimmune diseases or as a chemotherapeutic agent for hyperproliferative disorders such as hepatoma.

Formula: C₃₅H₄₃N₁₁O₁₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 841.78 g/mol

Ref: 3D-FM57710