CAS 73644-58-3

TRH-.beta.NA

Description:

TRH-.beta.NA, also known as Thyrotropin-Releasing Hormone beta-Naphthylamide, is a synthetic peptide derivative that plays a role in the regulation of thyroid-stimulating hormone (TSH) release. This compound is characterized by its structural composition, which includes a peptide backbone and a beta-naphthylamide moiety, contributing to its biological activity. It is typically used in research settings to study the mechanisms of hormone regulation and the physiological effects of TRH on the endocrine system. The substance is soluble in various organic solvents, which facilitates its use in laboratory experiments. Its pharmacological properties may include modulation of neuroendocrine functions, making it of interest in studies related to thyroid disorders and metabolic regulation. Safety and handling precautions are essential, as with any chemical substance, to mitigate potential risks associated with its use. Overall, TRH-.beta.NA serves as a valuable tool in biochemical research, particularly in understanding the complexities of hormone signaling pathways.

Formula: C₂₆H₂₈N₆O₄

InChI: InChI=1/C26H28N6O4/c33-23-10-9-20(29-23)24(34)30-21(13-18-14-27-15-28-18)25(35)31-26(36)22-6-3-11-32(22)19-8-7-16-4-1-2-5-17(16)12-19/h1-2,4-5,7-8,12,14-15,18,20-22H,3,6,9-11,13H2,(H,29,33)(H,30,34)(H,31,35,36)/t18?,20-,21-,22-/m0/s1

SMILES: c1ccc2cc(ccc2c1)N1CCC[C@H]1C(=O)N=C([C@H](CC1C=NC=N1)N=C([C@@H]1CCC(=N1)O)O)O

Synonyms:

• Pyr-His-Pro-.beta.NA
• 5-oxo-L-prolyl-3-(4H-imidazol-4-yl)-N-{[(2S)-1-(naphthalen-2-yl)pyrrolidin-2-yl]carbonyl}-L-alaninamide

TRH-betaNA

CAS: 73644-58-3

TRH-betaNA is a peptide that is found in the brain and released by the hypothalamus. It binds to thyrotropin-releasing hormone receptors on neurons in the brain, causing it to release thyrotropin. It also binds to neuroendocrine cells in the anterior pituitary gland and stimulates the production of thyroid hormones. TRH-betaNA is metabolized by endopeptidases, which are enzymes that break down proteins into smaller chains of amino acids. The enzyme metalloenzyme is involved in this process, although its exact function is unknown.

Formula: C₂₆H₂₈N₆O₄

Purity: Min. 95%

Molecular weight: 488.54 g/mol

Ref: 3D-FT110681

TRH-βNA

CAS: 73644-58-3

A sensitive and highly specific substrate for a rapid assay of rat brain TRH-deamidating enzyme (prolyl endopeptidase). TRH-βNA is also hydrolyzed by another TRH-degrading enzyme, pyroglutamyl peptidase II (thyroliberinase), which seems to play a key role in terminating the biological activity of neuronally released TRH.

Formula: C₂₆H₂₈N₆O₄

Purity: > 99%

Color and Shape: White Lyophilisate

Molecular weight: 488.55

Ref: 01-4004755