CAS 73731-37-0

fmoc-L-threonine monohydrate

Description:

Fmoc-L-threonine monohydrate is a derivative of the amino acid threonine, characterized by the presence of a 9-fluorenylmethoxycarbonyl (Fmoc) protecting group. This compound is typically used in peptide synthesis, particularly in solid-phase peptide synthesis, due to its ability to protect the amino group of threonine while allowing for further reactions. The monohydrate form indicates that the compound contains one molecule of water per molecule of Fmoc-L-threonine, which can influence its solubility and stability. Fmoc-L-threonine itself is a polar, hydrophilic amino acid, contributing to the overall properties of the compound. It is generally soluble in organic solvents like dimethylformamide (DMF) and dimethyl sulfoxide (DMSO), while being less soluble in water. The presence of the Fmoc group provides a convenient means for deprotection under mild basic conditions, facilitating the synthesis of peptides with specific sequences. Overall, Fmoc-L-threonine monohydrate is a valuable reagent in the field of organic chemistry and biochemistry for the construction of peptides.

Formula: C₁₉H₁₉NO₅

InChI: InChI=1/C19H19NO5/c1-11(21)17(18(22)23)20-19(24)25-10-16-14-8-4-2-6-12(14)13-7-3-5-9-15(13)16/h2-9,11,16-17,21H,10H2,1H3,(H,20,24)(H,22,23)/t11-,17+/m1/s1

InChI key: OYULCCKKLJPNPU-DIFFPNOSSA-N

SMILES: C[C@H]([C@@H](C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13)O

Synonyms:

• Fmoc-Thr-OH monohydrate
• Fmoc-L-Threonine-OH
• Fmoc-L-Thr-OH
• N-[(9H-Fluoren-9ylmethoxy)carbonyl]-L-threonine
• N-[(9H-fluoren-9-ylmethoxy)carbonyl]threonine
• (2S,3S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-hydroxybutanoate
• N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-allothreonine
• Fmoc-Thr-OH.H2O
• Fmoc-L-threonine
• Fmoc-Thr-OH
• 2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-3-Hydroxy-Butanoic Acid
• N-FMOC-L-THREONINE
• FMOC-L-THREONINE extrapure
• N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-L-THREONINE MONOHYDRATE
• N-FMOC-L-THREONINE MONOHYDRATE
• FMOC-L-THR-OH H2O
• N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-THREONINE
• FMOC-THR
• FMOC-L-THREONINE MONOHYDRATE
• FMOC-THREONINE
• N-ALPHA-FMOC-L-THREONINE
• N-(9-FLUORENYLMETHOXYCARBONYL)-L-THREONINE

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-threonine Monohydrate

CAS: 73731-37-0

Formula: C₁₉H₁₉NO₅·H₂O

Purity: >98.0%(HPLC)(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 359.38

Ref: 3B-F0455

Fmoc-Thr-OH

CAS: 73731-37-0

Educt for the synthesis of O-glycosylated threonine building blocks. Liu et al. described the synthesis of O-mannosylated Fmoc-Thr.

Formula: C₁₉H₁₉NO₅

Purity: 99.78%

Color and Shape: White Powder

Molecular weight: 341.36

Ref: 01-4015218

Fmoc-Thr-OH

CAS: 73731-37-0

Formula: C₁₉H₁₉NO₅

Purity: 95%

Color and Shape: Solid

Molecular weight: 341.3579

Ref: IN-DA003QNM

Fmoc-Thr-OH monohydrate

CAS: 73731-37-0

Formula: C₁₉H₁₉NO₅H₂O

Molecular weight: 359.38

Ref: 7W-GM5550

Fmoc-L-Threonine

CAS: 73731-37-0

Fmoc-L-Threonine

Formula: C₁₉H₁₉NO₅

Purity: >98%

Color and Shape: Solid

Molecular weight: 341.36

Ref: 54-OR1013373

Fmoc-Thr-OH

CAS: 73731-37-0

(2S,3R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-hydroxybutanoic acid

Formula: C₁₉H₁₉NO₅

Purity: 95%

Molecular weight: 341.36

Ref: IN-DG1036

Fmoc-Thr-OH

CAS: 73731-37-0

M03388 - Fmoc-Thr-OH

Formula: C₁₉H₁₉NO₅

Purity: 95%

Color and Shape: Solid

Molecular weight: 341.363

Ref: 10-M03388

FMOC-L-Threonine extrapure, 99%

CAS: 73731-37-0

Formula: C₁₉H₁₉NO₅

Purity: min. 99%

Color and Shape: White, Crystalline powder

Molecular weight: 341.40

Ref: SR-64712

Fmoc-Thr-OH

CAS: 73731-37-0

Fmoc-Thr-OH is a synthetic amino acid that has been used in the synthesis of peptides and glycopeptides. It is also a good building block for the construction of sialic acid derivatives. The Fmoc group can be removed by treating the compound with trifluoroacetic acid (TFA), which yields an unprotected l-threonine residue. This is then reacted with a benzyl ester to form an amide bond, forming an Fmoc-protected lactam. The chloride group on the benzyl ester can then be displaced by a reactive electrophile, such as trifluoroacetic acid (TFA) or N-hydroxysuccinimide, to form the desired product.
The analytical hplc method for quantifying Fmoc-Thr-OH uses choline as an internal standard and detects peaks at Rt = 1.80 min. The molecular weight of F

Formula: C₁₉H₁₉NO₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 341.36 g/mol

Ref: 3D-FF37962